S-arrestin - GPR65 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
GPR65 81.3
S-arrestin 81.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 120 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 120 34x51 S8 L 136 N.S8.03
Polar ICL2 R 126 34x57 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 R 126 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 126 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL3 N 213 - S6 F 83 N.S6.01
Polar C-term S 324 - S6 R 84 N.S6.02
Van-der-waals C-term S 324 - S6 R 84 N.S6.02
Polar C-term S 326 - S6 D 86 N.S6.04
Hydrophobic C-term S 326 - S6 D 86 N.S6.04
Van-der-waals C-term S 326 - S6 D 86 N.S6.04
Hydrophobic ICL2 P 119 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 119 34x50 S5 Y 71 N.S5.12
Hydrophobic C-term L 333 - s7s8 Y 129 N.s7s8.05
Hydrophobic TM6 L 228 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 R 112 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 112 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 F 123 34x54 s8s9 P 138 N.s8s9.02
Van-der-waals ICL2 F 123 34x54 s8s9 P 138 N.s8s9.02
Ionic TM2 E 48 2x38 s8s9 K 145 N.s8s9.09
Polar TM2 E 48 2x38 s8s9 K 145 N.s8s9.09
Polar ICL3 K 214 - s15s16 L 253 C.s15s16.02
Hydrophobic ICL3 K 214 - s15s16 L 253 C.s15s16.02
Van-der-waals ICL3 K 214 - s15s16 L 253 C.s15s16.02
Polar TM3 A 115 3x53 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 227 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 227 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic C-term K 320 - s9s10 K 167 N.s9s10.09
Polar C-term R 319 - s9s10 K 170 N.s9s10.12
Hydrophobic C-term R 319 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term R 319 - s9s10 K 170 N.s9s10.12
Polar TM3 V 116 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 V 116 3x54 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 V 116 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic C-term L 323 - s9s10 D 166 N.s9s10.08
Van-der-waals C-term L 323 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 F 123 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 F 123 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 V 116 3x54 S6 F 83 N.S6.01
Hydrophobic ICL2 L 120 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 120 34x51 S16 Y 259 C.S16.03
Polar ICL3 K 214 - S6 R 85 N.S6.03
Hydrophobic ICL3 K 214 - S6 R 85 N.S6.03
Van-der-waals ICL3 K 214 - S6 R 85 N.S6.03
Hydrophobic ICL2 L 120 34x51 S15 V 251 C.S15.14
Hydrophobic ICL3 A 215 - S5 F 69 N.S5.10
Hydrophobic H8 T 294 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 T 294 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic ICL3 K 214 - s17s18 T 323 C.s17s18.39
Van-der-waals ICL3 K 214 - s17s18 T 323 C.s17s18.39
Polar C-term V 325 - s9s10 D 166 N.s9s10.08
Hydrophobic ICL2 L 120 34x51 S9 C 147 N.S9.01
Hydrophobic C-term M 331 - S6 R 85 N.S6.03
Van-der-waals C-term M 331 - S6 R 85 N.S6.03
Hydrophobic H8 T 294 8x47 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 I 224 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 I 224 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic ICL3 N 213 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 N 213 - s15s16 Y 254 C.s15s16.03
Polar ICL3 A 215 - s15s16 L 253 C.s15s16.02
Hydrophobic ICL3 A 215 - s15s16 L 253 C.s15s16.02
Van-der-waals ICL3 A 215 - s15s16 L 253 C.s15s16.02
Hydrophobic ICL2 P 119 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL3 N 213 - s15s16 L 253 C.s15s16.02
Hydrophobic ICL2 F 123 34x54 s8s9 D 142 N.s8s9.06
Hydrophobic TM5 V 206 5x61 s5s6 I 79 N.s5s6.08
Polar C-term Q 318 - s20c E 405 C.s20c.24
Hydrophobic C-term Q 318 - s20c E 405 C.s20c.24
Van-der-waals C-term Q 318 - s20c E 405 C.s20c.24
Van-der-waals ICL3 T 216 - S6 F 83 N.S6.01
Polar TM3 R 112 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 112 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 112 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 R 126 34x57 s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 R 126 34x57 s5s6 I 76 N.s5s6.05
Hydrophobic C-term L 323 - s9s10 K 167 N.s9s10.09
Hydrophobic ICL3 A 215 - S6 R 85 N.S6.03
Van-der-waals ICL3 A 215 - S6 R 85 N.S6.03
Ionic ICL2 K 121 34x52 S16 D 257 C.S16.01
Polar ICL2 K 121 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 K 121 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 K 121 34x52 S16 D 257 C.S16.01
Van-der-waals C-term K 320 - s9s10 D 166 N.s9s10.08
Hydrophobic C-term K 328 - S6 F 89 N.S6.07
Van-der-waals C-term K 328 - S6 F 89 N.S6.07
Hydrophobic TM3 A 115 3x53 s5s6 V 78 N.s5s6.07
Polar C-term S 324 - s9s10 D 166 N.s9s10.08
Hydrophobic C-term S 324 - s9s10 D 166 N.s9s10.08
Van-der-waals C-term S 324 - s9s10 D 166 N.s9s10.08
Hydrophobic TM3 V 116 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 K 121 34x52 S16 Y 259 C.S16.03
Polar H8 E 295 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 E 295 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 L 120 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 120 34x51 S5 Y 71 N.S5.12
Hydrophobic H8 T 294 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic C-term R 319 - s9s10 K 171 N.s9s10.13
Van-der-waals C-term R 319 - s9s10 K 171 N.s9s10.13
Hydrophobic C-term R 319 - s9s10 P 169 N.s9s10.11
Polar H8 T 296 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 T 296 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 T 296 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 L 49 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 49 2x39 s5s6 V 78 N.s5s6.07