Beta-arrestin-1 - PAF receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PAF 79.0
Beta-arrestin-1 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 119 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 230 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 I 123 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 I 123 34x51 S16 A 247 C.S16.01
Hydrophobic TM6 M 233 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 M 233 6x37 s5s6 L 71 N.s5s6.08
Polar ICL2 N 129 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 N 129 34x57 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 N 129 34x57 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 V 119 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 V 119 3x54 s5s6 L 71 N.s5s6.08
Polar TM7 K 298 7x58 s5s6 D 69 N.s5s6.06
Hydrophobic TM7 K 298 7x58 s5s6 D 69 N.s5s6.06
Van-der-waals TM7 K 298 7x58 s5s6 D 69 N.s5s6.06
Hydrophobic TM5 I 209 5x61 s5s6 L 71 N.s5s6.08
Polar TM7 K 299 7x59 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 115 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 115 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 I 123 34x51 S5 Y 63 N.S5.12
Hydrophobic ICL2 I 123 34x51 S5 Y 63 N.S5.12
Van-der-waals ICL2 I 123 34x51 S5 Y 63 N.S5.12
Polar ICL2 A 126 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 A 126 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 A 126 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 I 123 34x51 s15s16 F 244 C.s15s16.03
Polar ICL3 Q 220 - S6 D 78 N.S6.04
Hydrophobic ICL3 Q 220 - S6 D 78 N.S6.04
Van-der-waals ICL3 Q 220 - S6 D 78 N.S6.04
Ionic TM7 K 298 7x58 s20c E 407 C.s20c.17
Polar TM7 K 298 7x58 s20c E 407 C.s20c.17
Hydrophobic TM7 K 298 7x58 s20c E 407 C.s20c.17
Van-der-waals TM7 K 298 7x58 s20c E 407 C.s20c.17
Hydrophobic ICL2 Q 127 34x55 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 Q 127 34x55 s8s9 G 137 N.s8s9.08
Hydrophobic TM5 Q 216 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 Q 216 5x68 S6 F 75 N.S6.01
Polar TM3 R 121 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 R 121 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 R 121 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 R 222 6x26 S10 R 165 N.S10.03
Van-der-waals TM6 R 222 6x26 S10 R 165 N.S10.03
Ionic ICL1 K 48 - s20c D 402 C.s20c.12
Polar ICL1 K 48 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 48 - s20c D 402 C.s20c.12
Hydrophobic TM5 L 213 5x65 s5s6 L 71 N.s5s6.08
Polar ICL2 Q 127 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 Q 127 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 Q 127 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 A 126 34x54 s8s9 K 138 N.s8s9.09
Van-der-waals ICL2 A 126 34x54 s8s9 K 138 N.s8s9.09
Polar TM3 R 115 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 115 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 115 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 A 126 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 A 126 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 A 126 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 A 126 34x54 S5 Y 63 N.S5.12
Van-der-waals ICL2 A 126 34x54 S5 Y 63 N.S5.12
Polar ICL2 A 128 34x56 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 A 128 34x56 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 A 128 34x56 s8s9 T 136 N.s8s9.07
Polar ICL3 Q 219 - S6 D 78 N.S6.04
Van-der-waals ICL3 Q 219 - S6 D 78 N.S6.04
Ionic TM6 E 225 6x29 s9s10 K 157 N.s9s10.09
Polar TM6 A 230 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 230 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 230 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 T 297 7x57 s5s6 D 69 N.s5s6.06
Polar TM2 N 50 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 N 50 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 N 50 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 I 123 34x51 S15 I 241 C.S15.14
Van-der-waals ICL2 I 123 34x51 S15 I 241 C.S15.14
Polar ICL2 P 122 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 122 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 122 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 122 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 K 124 34x52 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 L 213 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 213 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 V 226 6x30 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 V 226 6x30 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 V 234 6x38 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 I 123 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 I 123 34x51 s15s16 N 245 C.s15s16.04
Polar TM6 Q 221 6x25 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 Q 221 6x25 s9s10 E 155 N.s9s10.07
Hydrophobic TM3 A 118 3x53 s5s6 L 68 N.s5s6.05
Ionic TM7 K 299 7x59 s20c E 405 C.s20c.15
Polar TM7 K 299 7x59 s20c E 405 C.s20c.15
Hydrophobic TM7 K 299 7x59 s20c E 405 C.s20c.15
Van-der-waals TM7 K 299 7x59 s20c E 405 C.s20c.15
Hydrophobic ICL2 P 122 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 P 122 34x50 S6 F 75 N.S6.01
Hydrophobic ICL2 A 126 34x54 s5s6 L 68 N.s5s6.05
Van-der-waals ICL2 A 126 34x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 K 124 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 K 124 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 A 118 3x53 s5s6 V 70 N.s5s6.07
Polar TM4 T 130 4x38 s5s6 R 65 N.s5s6.02
Van-der-waals TM4 T 130 4x38 s5s6 R 65 N.s5s6.02
Polar TM4 T 130 4x38 s8s9 T 136 N.s8s9.07
Hydrophobic TM4 T 130 4x38 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 T 130 4x38 s8s9 T 136 N.s8s9.07
Polar ICL2 N 129 34x57 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 N 129 34x57 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 N 129 34x57 s8s9 E 134 N.s8s9.05
Polar ICL2 Q 127 34x55 S16 Y 249 C.S16.03
Hydrophobic ICL2 Q 127 34x55 S16 Y 249 C.S16.03
Van-der-waals ICL2 Q 127 34x55 S16 Y 249 C.S16.03
Hydrophobic TM6 V 226 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 V 226 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 Q 127 34x55 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 Q 127 34x55 s8s9 D 135 N.s8s9.06
Hydrophobic TM2 I 52 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 I 123 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 I 123 34x51 s15s16 L 243 C.s15s16.02
Van-der-waals TM3 A 118 3x53 S6 F 75 N.S6.01
Van-der-waals TM7 L 296 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 V 119 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 Q 127 34x55 S16 A 247 C.S16.01
Van-der-waals ICL2 Q 127 34x55 S16 A 247 C.S16.01