S-arrestin - PTH1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
PTH1 66.5
S-arrestin 81.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 19.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM4 E 317 4x39 s8s9 K 145 N.s8s9.09
Polar TM4 E 317 4x39 s8s9 K 145 N.s8s9.09
Hydrophobic TM4 E 317 4x39 s8s9 K 145 N.s8s9.09
Van-der-waals TM4 E 317 4x39 s8s9 K 145 N.s8s9.09
Hydrophobic ICL3 R 396 - S6 F 89 N.S6.07
Van-der-waals ICL3 R 396 - S6 F 89 N.S6.07
Polar ICL3 T 392 - S6 D 86 N.S6.04
Hydrophobic ICL3 T 392 - S6 D 86 N.S6.04
Van-der-waals ICL3 T 392 - S6 D 86 N.S6.04
Polar TM6 S 409 6x41 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 S 409 6x41 s5s6 I 79 N.s5s6.08
Ionic ICL3 E 391 - S6 R 85 N.S6.03
Polar ICL3 E 391 - S6 R 85 N.S6.03
Hydrophobic ICL3 E 391 - S6 R 85 N.S6.03
Van-der-waals ICL3 E 391 - S6 R 85 N.S6.03
Hydrophobic ICL3 T 392 - S6 R 85 N.S6.03
Hydrophobic ICL3 T 392 - S6 R 84 N.S6.02
Van-der-waals ICL3 T 392 - S6 R 84 N.S6.02
Polar TM4 K 318 4x40 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 K 318 4x40 s8s9 Q 141 N.s8s9.05
Polar ICL3 E 391 - s15s16 Y 254 C.s15s16.03
Polar ICL2 A 313 - S16 D 257 C.S16.01
Van-der-waals ICL2 A 313 - S16 D 257 C.S16.01
Hydrophobic TM3 F 311 3x59 s15s16 S 255 C.s15s16.04
Van-der-waals TM3 F 311 3x59 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 F 314 - S8 L 136 N.S8.03
Van-der-waals ICL2 F 314 - S8 L 136 N.S8.03
Polar ICL2 A 313 - S16 Y 259 C.S16.03
Hydrophobic ICL2 A 313 - S16 Y 259 C.S16.03
Hydrophobic TM2 R 219 2x46 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 R 219 2x46 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 L 389 5x65 s5s6 L 81 N.s5s6.10
Polar TM6 K 405 6x37 s5s6 G 80 N.s5s6.09
Hydrophobic ICL2 A 313 - S15 V 251 C.S15.14
Polar TM3 M 312 3x60 S5 Y 71 N.S5.12
Hydrophobic TM3 M 312 3x60 S5 Y 71 N.S5.12
Van-der-waals TM3 M 312 3x60 S5 Y 71 N.S5.12
Polar TM2 R 219 2x46 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 R 219 2x46 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 F 314 - S9 C 147 N.S9.01
Van-der-waals ICL2 F 314 - S9 C 147 N.S9.01
Hydrophobic TM7 Y 459 7x57 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 459 7x57 s5s6 V 78 N.s5s6.07
Polar TM4 E 317 4x39 s5s6 Q 73 N.s5s6.02
Van-der-waals TM4 E 317 4x39 s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 I 310 3x58 S6 F 83 N.S6.01
Hydrophobic ICL2 F 314 - s8s9 P 138 N.s8s9.02
Hydrophobic TM5 L 385 5x61 S6 F 83 N.S6.01
Polar ICL2 F 314 - S16 Y 259 C.S16.03
Aromatic ICL2 F 314 - S16 Y 259 C.S16.03
Hydrophobic ICL2 F 314 - S16 Y 259 C.S16.03
Van-der-waals ICL2 F 314 - S16 Y 259 C.S16.03
Polar TM3 L 309 3x57 S5 Y 71 N.S5.12
Hydrophobic TM3 L 309 3x57 S5 Y 71 N.S5.12
Van-der-waals TM3 L 309 3x57 S5 Y 71 N.S5.12
Polar TM3 F 311 3x59 S5 Y 71 N.S5.12
Hydrophobic TM6 S 409 6x41 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 F 314 - s8s9 Q 137 N.s8s9.01
Hydrophobic TM3 L 309 3x57 s8s9 K 145 N.s8s9.09
Van-der-waals TM3 L 309 3x57 s8s9 K 145 N.s8s9.09
Polar TM3 I 310 3x58 S5 Y 71 N.S5.12
Hydrophobic TM3 I 310 3x58 S5 Y 71 N.S5.12
Van-der-waals TM3 I 310 3x58 S5 Y 71 N.S5.12
Polar ICL2 F 315 - s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 F 315 - s8s9 K 145 N.s8s9.09
Hydrophobic TM5 L 385 5x61 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 I 310 3x58 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 M 312 3x60 S16 D 257 C.S16.01
Van-der-waals TM3 M 312 3x60 S16 D 257 C.S16.01
Aromatic TM5 K 388 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 388 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 388 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 F 314 - S15 V 251 C.S15.14
Aromatic TM5 K 388 5x64 S6 F 83 N.S6.01
Hydrophobic TM5 K 388 5x64 S6 F 83 N.S6.01
Van-der-waals TM5 K 388 5x64 S6 F 83 N.S6.01
Polar ICL2 A 313 - S5 Y 71 N.S5.12
Hydrophobic ICL2 A 313 - S5 Y 71 N.S5.12
Van-der-waals ICL2 A 313 - S5 Y 71 N.S5.12
Hydrophobic TM6 L 413 6x45 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 L 385 5x61 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 L 306 3x54 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 K 405 6x37 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 K 405 6x37 s5s6 L 81 N.s5s6.10