Beta-arrestin-2 - PTH2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
PTH2 68.6
Beta-arrestin-2 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 17.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic TM5 E 346 5x67 S6 K 78 N.S6.03
Polar TM5 E 346 5x67 S6 K 78 N.S6.03
Van-der-waals TM5 E 346 5x67 S6 K 78 N.S6.03
Hydrophobic TM2 R 176 2x46 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 R 176 2x46 s5s6 V 71 N.s5s6.07
Polar ICL2 T 273 - s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 T 273 - s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 T 273 - s8s9 E 135 N.s8s9.05
Hydrophobic TM3 L 264 3x57 s5s6 R 66 N.s5s6.02
Polar C-term S 498 - S20 D 390 C.S20.05
Hydrophobic TM6 L 368 6x45 s5s6 L 72 N.s5s6.08
Hydrophobic H8 E 419 8x49 s5s6 V 71 N.s5s6.07
Polar ICL2 A 268 - S16 Y 250 C.S16.03
Hydrophobic ICL2 A 268 - S16 Y 250 C.S16.03
Van-der-waals ICL2 A 268 - S16 Y 250 C.S16.03
Polar ICL2 F 270 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 F 270 - s5s6 R 66 N.s5s6.02
Hydrophobic TM3 L 264 3x57 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 L 264 3x57 s5s6 L 69 N.s5s6.05
Hydrophobic ICL1 R 171 12x49 s20c L 408 C.s20c.18
Hydrophobic TM3 I 265 3x58 s5s6 L 74 N.s5s6.10
Polar TM6 S 364 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 L 261 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic C-term L 492 - s19s20 D 385 C.s19s20.51
Van-der-waals C-term L 492 - s19s20 D 385 C.s19s20.51
Polar ICL1 R 171 12x49 s20c C 409 C.s20c.19
Hydrophobic ICL1 R 171 12x49 s20c C 409 C.s20c.19
Van-der-waals ICL1 R 171 12x49 s20c C 409 C.s20c.19
Hydrophobic ICL2 F 269 - s8s9 P 132 N.s8s9.02
Hydrophobic ICL2 A 268 - S15 I 242 C.S15.14
Van-der-waals ICL2 A 268 - S15 I 242 C.S15.14
Hydrophobic ICL3 A 349 - S6 D 79 N.S6.04
Van-der-waals ICL3 A 349 - S6 D 79 N.S6.04
Hydrophobic TM5 K 343 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 343 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 F 269 - s8s9 A 140 N.s8s9.10
Ionic ICL1 R 171 12x49 s20c D 406 C.s20c.16
Polar ICL1 R 171 12x49 s20c D 406 C.s20c.16
Hydrophobic ICL1 R 171 12x49 s20c D 406 C.s20c.16
Van-der-waals ICL1 R 171 12x49 s20c D 406 C.s20c.16
Hydrophobic H8 E 419 8x49 s20c L 408 C.s20c.18
Van-der-waals H8 E 419 8x49 s20c L 408 C.s20c.18
Polar ICL2 A 268 - S5 Y 64 N.S5.12
Hydrophobic ICL2 A 268 - S5 Y 64 N.S5.12
Van-der-waals ICL2 A 268 - S5 Y 64 N.S5.12
Hydrophobic C-term Y 495 - S20 F 388 C.S20.03
Van-der-waals C-term Y 495 - S20 F 388 C.S20.03
Hydrophobic TM5 L 340 5x61 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 340 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic H8 E 423 8x53 s20c L 408 C.s20c.18
Van-der-waals H8 E 423 8x53 s20c L 408 C.s20c.18
Polar TM3 F 266 3x59 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 F 266 3x59 s15s16 S 246 C.s15s16.04
Polar TM2 C 174 2x44 s20c C 409 C.s20c.19
Hydrophobic TM2 C 174 2x44 s20c C 409 C.s20c.19
Van-der-waals TM2 C 174 2x44 s20c C 409 C.s20c.19
Hydrophobic ICL2 F 269 - s8s9 Q 131 N.s8s9.01
Van-der-waals ICL2 F 269 - s8s9 Q 131 N.s8s9.01
Ionic H8 K 426 8x56 s20c D 406 C.s20c.16
Polar H8 K 426 8x56 s20c D 406 C.s20c.16
Hydrophobic ICL2 F 269 - S8 L 130 N.S8.03
Van-der-waals ICL2 F 269 - S8 L 130 N.S8.03
Polar TM6 K 360 6x37 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 K 360 6x37 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 K 360 6x37 s5s6 G 73 N.s5s6.09
Hydrophobic TM5 K 343 5x64 S6 F 76 N.S6.01
Van-der-waals TM5 K 343 5x64 S6 F 76 N.S6.01
Hydrophobic ICL2 F 269 - s17s18 G 287 C.s17s18.12
Polar TM3 I 265 3x58 S5 Y 64 N.S5.12
Polar TM3 F 266 3x59 S5 Y 64 N.S5.12
Hydrophobic TM6 V 367 6x44 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 I 265 3x58 s5s6 L 69 N.s5s6.05
Polar ICL1 H 173 12x51 s20c C 409 C.s20c.19
Hydrophobic ICL1 H 173 12x51 s20c C 409 C.s20c.19
Van-der-waals ICL1 H 173 12x51 s20c C 409 C.s20c.19
Van-der-waals ICL2 F 270 - s8s9 D 136 N.s8s9.06
Polar C-term C 504 - s1s2 C 17 N.s1s2.04
Hydrophobic C-term C 504 - s1s2 C 17 N.s1s2.04
Van-der-waals C-term C 504 - s1s2 C 17 N.s1s2.04
Hydrophobic TM5 T 347 5x68 S6 R 77 N.S6.02
Van-der-waals TM5 T 347 5x68 S6 R 77 N.S6.02
Hydrophobic TM3 L 261 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 L 261 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 E 346 5x67 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 E 346 5x67 s15s16 F 245 C.s15s16.03
Hydrophobic ICL1 L 172 12x50 s20c C 409 C.s20c.19
Polar ICL2 F 269 - S16 Y 250 C.S16.03
Aromatic ICL2 F 269 - S16 Y 250 C.S16.03
Hydrophobic ICL2 F 269 - S16 Y 250 C.S16.03
Van-der-waals ICL2 F 269 - S16 Y 250 C.S16.03
Hydrophobic TM5 T 347 5x68 S6 F 76 N.S6.01
Polar TM2 R 176 2x46 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 R 176 2x46 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 R 176 2x46 s5s6 D 68 N.s5s6.04
Ionic ICL2 D 272 - s5s6 R 66 N.s5s6.02
Polar ICL2 D 272 - s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 D 272 - s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 D 272 - s5s6 R 66 N.s5s6.02
Polar C-term S 500 - S20 D 390 C.S20.05
Van-der-waals TM2 R 176 2x46 s20c C 409 C.s20c.19
Hydrophobic H8 N 417 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 417 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 L 261 3x54 s5s6 L 74 N.s5s6.10