Arrestin-C - QRFP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
QRFP 71.5
Arrestin-C 80.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.5


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 256 5x80 S6 V 77 N.S6.07
Hydrophobic TM5 T 255 5x79 S6 Y 76 N.S6.06
Van-der-waals TM5 T 255 5x79 S6 Y 76 N.S6.06
Polar TM6 K 267 6x29 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 K 267 6x29 s5s6 T 70 N.s5s6.11
Hydrophobic TM5 V 247 5x71 s17s18 L 311 C.s17s18.40
Polar TM5 R 246 5x70 s15s16 Y 241 C.s15s16.03
Aromatic TM5 R 246 5x70 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 246 5x70 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 246 5x70 s15s16 Y 241 C.s15s16.03
Hydrophobic C-term L 416 - S19 V 347 C.S19.10
Van-der-waals C-term L 416 - S19 V 347 C.S19.10
Polar ICL3 K 259 - s9s10 N 150 N.s9s10.02
Van-der-waals ICL3 K 259 - s9s10 N 150 N.s9s10.02
Hydrophobic TM6 A 271 6x33 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 A 271 6x33 s5s6 I 67 N.s5s6.08
Polar C-term S 419 - S16 K 245 C.S16.02
Van-der-waals C-term S 419 - S16 K 245 C.S16.02
Hydrophobic TM2 T 80 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 T 80 2x39 s5s6 V 66 N.s5s6.07
Polar ICL2 K 154 34x54 s5s6 G 60 N.s5s6.01
Hydrophobic ICL2 K 154 34x54 s5s6 G 60 N.s5s6.01
Van-der-waals ICL2 K 154 34x54 s5s6 G 60 N.s5s6.01
Hydrophobic ICL3 H 257 - s9s10 E 152 N.s9s10.07
Ionic TM5 D 249 5x73 S6 K 73 N.S6.03
Polar TM5 D 249 5x73 S6 K 73 N.S6.03
Hydrophobic TM5 D 249 5x73 S6 K 73 N.S6.03
Van-der-waals TM5 D 249 5x73 S6 K 73 N.S6.03
Aromatic ICL2 Y 157 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 Y 157 34x57 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 Y 157 34x57 s5s6 R 61 N.s5s6.02
Hydrophobic C-term F 417 - s17s18 K 309 C.s17s18.38
Polar C-term F 417 - s17s18 T 301 C.s17s18.30
Hydrophobic TM3 L 147 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic C-term F 417 - S18 L 315 C.S18.02
Van-der-waals C-term F 417 - S18 L 315 C.S18.02
Hydrophobic TM3 H 149 3x56 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 F 151 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 K 154 34x54 s8s9 D 132 N.s8s9.06
Hydrophobic ICL3 E 260 - S6 V 77 N.S6.07
Hydrophobic C-term L 414 - s17s18 I 302 C.s17s18.31
Van-der-waals C-term L 414 - s17s18 I 302 C.s17s18.31
Hydrophobic ICL2 P 150 34x50 s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 P 150 34x50 s15s16 Y 241 C.s15s16.03
Ionic C-term R 412 - s3s4 D 28 N.s3s4.03
Polar ICL2 P 150 34x50 S16 D 244 C.S16.01
Polar ICL2 K 152 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 K 152 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 K 152 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 F 151 34x51 S5 F 57 N.S5.10
Van-der-waals ICL2 F 151 34x51 S5 F 57 N.S5.10
Polar TM3 R 143 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 143 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 143 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 M 153 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 M 153 34x53 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 M 153 34x53 s5s6 R 61 N.s5s6.02
Hydrophobic C-term L 416 - s12s13 E 203 C.s12s13.03
Van-der-waals C-term L 416 - s12s13 E 203 C.s12s13.03
Hydrophobic ICL2 F 151 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 F 151 34x51 S15 V 238 C.S15.14
Polar ICL3 G 258 - s9s10 E 152 N.s9s10.07
Hydrophobic TM5 V 247 5x71 s17s18 D 308 C.s17s18.37
Van-der-waals TM5 V 247 5x71 s17s18 D 308 C.s17s18.37
Polar ICL2 F 151 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 F 151 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 F 151 34x51 S16 Y 246 C.S16.03
Hydrophobic TM6 M 275 6x37 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 M 275 6x37 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 L 241 5x65 s5s6 L 69 N.s5s6.10
Ionic ICL2 K 152 34x52 S16 D 244 C.S16.01
Polar ICL2 K 152 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 K 152 34x52 S16 D 244 C.S16.01
Van-der-waals ICL2 K 152 34x52 S16 D 244 C.S16.01
Polar C-term A 415 - s17s18 I 303 C.s17s18.32
Van-der-waals C-term A 415 - s17s18 I 303 C.s17s18.32
Hydrophobic TM5 L 241 5x65 S6 F 71 N.S6.01
Hydrophobic C-term A 415 - s17s18 P 305 C.s17s18.34
Polar TM5 R 246 5x70 S6 K 73 N.S6.03
Van-der-waals TM5 R 246 5x70 S6 K 73 N.S6.03
Van-der-waals C-term L 414 - s10s11 E 174 C.s10s11.04
Hydrophobic C-term R 418 - S19 P 345 C.S19.08
Polar H8 N 336 8x47 s5s6 G 68 N.s5s6.09
Hydrophobic H8 N 336 8x47 s5s6 G 68 N.s5s6.09
Hydrophobic C-term F 417 - s17s18 I 303 C.s17s18.32
Van-der-waals C-term F 417 - s17s18 I 303 C.s17s18.32
Hydrophobic TM6 A 271 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 271 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 F 151 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 F 151 34x51 S8 L 126 N.S8.03
Hydrophobic TM5 V 252 5x76 S6 L 75 N.S6.05
Van-der-waals TM5 V 252 5x76 S6 L 75 N.S6.05
Hydrophobic TM3 G 146 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 G 146 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 L 147 3x54 s15s16 Y 241 C.s15s16.03
Polar ICL2 K 154 34x54 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 K 154 34x54 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 K 154 34x54 s5s6 R 61 N.s5s6.02
Polar ICL2 F 151 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 F 151 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 F 151 34x51 S16 D 244 C.S16.01
Hydrophobic TM6 M 274 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 M 274 6x36 s5s6 I 67 N.s5s6.08
Aromatic ICL2 W 155 34x55 s17s18 R 282 C.s17s18.11
Hydrophobic ICL2 W 155 34x55 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 W 155 34x55 s17s18 R 282 C.s17s18.11
Ionic ICL3 K 259 - s9s10 E 152 N.s9s10.07
Polar ICL3 K 259 - s9s10 E 152 N.s9s10.07
Hydrophobic ICL3 K 259 - s9s10 E 152 N.s9s10.07
Van-der-waals ICL3 K 259 - s9s10 E 152 N.s9s10.07
Polar ICL2 P 150 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 150 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 150 34x50 S5 Y 59 N.S5.12
Van-der-waals TM5 R 246 5x70 s17s18 E 310 C.s17s18.39
Hydrophobic ICL2 P 150 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 150 34x50 s15s16 S 242 C.s15s16.04
Polar C-term S 419 - S15 D 237 C.S15.13
Van-der-waals C-term S 419 - S15 D 237 C.S15.13
Polar TM5 V 247 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 V 247 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 V 247 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic C-term L 414 - s3s4 V 27 N.s3s4.02
Hydrophobic C-term L 414 - s17s18 R 304 C.s17s18.33
Hydrophobic C-term L 416 - s17s18 I 302 C.s17s18.31
Polar ICL2 P 150 34x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 150 34x50 s5s6 R 61 N.s5s6.02
Polar H8 N 338 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 338 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 338 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 V 148 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 V 148 3x55 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 F 151 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 F 151 34x51 S9 C 137 N.S9.01
Hydrophobic TM6 K 267 6x29 s5s6 L 69 N.s5s6.10
Polar C-term S 419 - S18 S 317 C.S18.04
Hydrophobic TM3 R 143 3x50 s5s6 I 67 N.s5s6.08
Ionic C-term R 418 - s12s13 E 203 C.s12s13.03
Polar C-term R 418 - s12s13 E 203 C.s12s13.03
Van-der-waals C-term R 418 - s12s13 E 203 C.s12s13.03
Hydrophobic ICL2 Y 157 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 Y 157 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 I 256 5x80 S6 D 74 N.S6.04
Van-der-waals TM5 I 256 5x80 S6 D 74 N.S6.04
Polar ICL2 K 154 34x54 S5 Y 59 N.S5.12
Aromatic ICL2 K 154 34x54 S5 Y 59 N.S5.12
Ionic TM3 H 149 3x56 S16 D 244 C.S16.01
Polar TM3 H 149 3x56 S16 D 244 C.S16.01
Hydrophobic TM3 H 149 3x56 S16 D 244 C.S16.01
Van-der-waals TM3 H 149 3x56 S16 D 244 C.S16.01
Hydrophobic TM5 V 252 5x76 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 V 252 5x76 s17s18 L 311 C.s17s18.40
Hydrophobic TM5 G 248 5x72 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 G 248 5x72 s17s18 L 311 C.s17s18.40
Polar H8 N 336 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 336 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 336 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic TM3 L 147 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 L 147 3x54 S6 F 71 N.S6.01
Polar ICL2 F 151 34x51 S5 Y 59 N.S5.12
Aromatic ICL2 F 151 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 F 151 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 F 151 34x51 S5 Y 59 N.S5.12
Van-der-waals TM5 T 255 5x79 S6 V 77 N.S6.07
Polar ICL2 K 152 34x52 s15s16 L 243 C.s15s16.05