Beta-arrestin-2 - RXFP3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
RXFP3 65.6
Beta-arrestin-2 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 180 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 180 3x50 s5s6 V 71 N.s5s6.07
Aromatic TM6 R 320 6x29 S6 F 76 N.S6.01
Hydrophobic TM6 R 320 6x29 S6 F 76 N.S6.01
Van-der-waals TM6 R 320 6x29 S6 F 76 N.S6.01
Hydrophobic TM5 L 290 5x61 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 L 290 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 180 3x50 s5s6 L 69 N.s5s6.05
Polar ICL2 A 187 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 A 187 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 A 187 - s15s16 F 245 C.s15s16.03
Ionic ICL2 H 191 - s17s18 E 314 C.s17s18.39
Polar ICL2 H 191 - s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 H 191 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL2 H 191 - s17s18 E 314 C.s17s18.39
Hydrophobic TM4 C 211 4x39 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 V 184 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 184 3x54 S6 F 76 N.S6.01
Hydrophobic TM6 K 323 6x32 s5s6 G 73 N.s5s6.09
Polar TM6 R 320 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 R 320 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 320 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM3 V 184 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic H8 E 395 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 E 395 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 K 114 2x36 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 K 114 2x36 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 L 188 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 L 188 - s15s16 F 245 C.s15s16.03
Hydrophobic TM5 I 294 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 294 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic H8 R 393 8x47 s5s6 D 70 N.s5s6.06
Polar TM6 V 324 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 324 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 324 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 V 184 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 184 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals ICL2 C 201 - S16 Q 249 C.S16.02
Polar TM2 S 115 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 115 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 115 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 V 324 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 324 6x33 s5s6 L 74 N.s5s6.10
Polar TM6 S 327 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 S 327 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 I 117 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 I 117 2x39 s5s6 D 68 N.s5s6.04
Polar TM6 R 320 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 R 320 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 R 320 6x29 S6 R 77 N.S6.02
Hydrophobic TM5 Y 287 5x58 s5s6 L 72 N.s5s6.08
Polar ICL2 G 207 - s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 G 207 - s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 G 207 - s8s9 T 137 N.s8s9.07
Hydrophobic TM3 S 183 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 S 183 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 R 319 6x28 s9s10 K 158 N.s9s10.09
Van-der-waals TM6 R 319 6x28 s9s10 K 158 N.s9s10.09
Hydrophobic TM6 S 327 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 328 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 328 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 180 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 S 115 2x37 s8s9 K 139 N.s8s9.09
Polar H8 R 394 8x48 s20c C 409 C.s20c.19
Polar H8 K 398 8x52 s20c D 403 C.s20c.13
Van-der-waals H8 K 398 8x52 s20c D 403 C.s20c.13
Hydrophobic TM6 V 324 6x33 s5s6 G 73 N.s5s6.09
Polar ICL2 H 191 - S6 K 78 N.S6.03
Hydrophobic H8 R 393 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 R 393 8x47 s5s6 V 71 N.s5s6.07
Ionic H8 R 394 8x48 s20c D 406 C.s20c.16
Polar H8 R 394 8x48 s20c D 406 C.s20c.16
Hydrophobic H8 R 394 8x48 s20c D 406 C.s20c.16
Van-der-waals H8 R 394 8x48 s20c D 406 C.s20c.16
Hydrophobic ICL2 G 203 - S16 K 251 C.S16.04
Hydrophobic ICL2 L 188 - S6 F 76 N.S6.01
Hydrophobic ICL2 S 190 - s15s16 T 247 C.s15s16.05
Hydrophobic TM5 L 290 5x61 s5s6 L 74 N.s5s6.10
Polar H8 R 394 8x48 s20c Q 407 C.s20c.17
Hydrophobic H8 R 394 8x48 s20c Q 407 C.s20c.17
Van-der-waals H8 R 394 8x48 s20c Q 407 C.s20c.17
Polar TM3 S 183 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 S 183 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 S 183 3x53 s5s6 R 66 N.s5s6.02
Polar ICL2 C 201 - S16 K 251 C.S16.04
Hydrophobic ICL2 C 201 - S16 K 251 C.S16.04
Van-der-waals ICL2 C 201 - S16 K 251 C.S16.04