S-arrestin - RXFP3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
RXFP3 64.9
S-arrestin 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term Y 448 - S15 E 246 C.S15.09
Van-der-waals C-term Y 448 - S15 E 246 C.S15.09
Ionic H8 R 394 8x48 s8s9 D 142 N.s8s9.06
Polar H8 R 394 8x48 s8s9 D 142 N.s8s9.06
Hydrophobic C-term E 442 - s17s18 E 293 C.s17s18.09
Van-der-waals C-term E 442 - s17s18 E 293 C.s17s18.09
Hydrophobic C-term Y 447 - S16 V 260 C.S16.04
Van-der-waals C-term Y 447 - S16 V 260 C.S16.04
Hydrophobic TM6 R 320 6x29 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 R 320 6x29 s5s6 L 81 N.s5s6.10
Hydrophobic TM7 V 392 7x56 s5s6 V 78 N.s5s6.07
Polar TM2 K 114 2x36 S16 D 257 C.S16.01
Hydrophobic TM2 K 114 2x36 S16 D 257 C.S16.01
Van-der-waals TM2 K 114 2x36 S16 D 257 C.S16.01
Hydrophobic C-term Y 447 - S16 Y 259 C.S16.03
Hydrophobic C-term Y 455 - S11 A 197 C.S11.04
Hydrophobic C-term L 463 - s10s11 P 190 C.s10s11.07
Van-der-waals C-term L 463 - s10s11 P 190 C.s10s11.07
Polar C-term Y 448 - S19 E 354 C.S19.06
Hydrophobic C-term Y 448 - S19 E 354 C.S19.06
Van-der-waals C-term Y 448 - S19 E 354 C.S19.06
Polar C-term Y 448 - S18 K 334 C.S18.08
Hydrophobic C-term Y 448 - S18 K 334 C.S18.08
Van-der-waals C-term Y 448 - S18 K 334 C.S18.08
Hydrophobic C-term L 463 - s12s13 E 216 C.s12s13.03
Van-der-waals C-term L 463 - s12s13 E 216 C.s12s13.03
Hydrophobic H8 R 393 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 393 8x47 s5s6 D 77 N.s5s6.06
Polar H8 R 394 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 394 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 S 183 3x53 s15s16 Y 254 C.s15s16.03
Van-der-waals TM3 S 183 3x53 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 L 188 - S6 F 83 N.S6.01
Polar H8 K 398 8x52 s8s9 Q 141 N.s8s9.05
Hydrophobic H8 K 398 8x52 s8s9 Q 141 N.s8s9.05
Van-der-waals H8 K 398 8x52 s8s9 Q 141 N.s8s9.05
Hydrophobic TM3 V 184 3x54 s5s6 I 76 N.s5s6.05
Hydrophobic H8 R 394 8x48 s5s6 E 74 N.s5s6.03
Hydrophobic C-term P 443 - S16 M 265 C.S16.09
Hydrophobic C-term P 443 - s17s18 R 294 C.s17s18.10
Van-der-waals C-term P 443 - s17s18 R 294 C.s17s18.10
Polar C-term Y 460 - S19 T 353 C.S19.05
Hydrophobic C-term L 446 - S15 F 244 C.S15.07
Van-der-waals C-term L 446 - S15 F 244 C.S15.07
Hydrophobic TM3 V 184 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 184 3x54 S6 F 83 N.S6.01
Hydrophobic C-term L 445 - S16 P 262 C.S16.06
Polar TM2 S 115 2x37 S16 D 257 C.S16.01
Hydrophobic TM2 S 115 2x37 S16 D 257 C.S16.01
Van-der-waals TM2 S 115 2x37 S16 D 257 C.S16.01
Hydrophobic TM4 C 210 4x38 s15s16 S 256 C.s15s16.05
Hydrophobic C-term Y 448 - S19 A 352 C.S19.04
Polar TM5 G 304 5x75 s9s10 K 167 N.s9s10.09
Hydrophobic TM5 G 304 5x75 s9s10 K 167 N.s9s10.09
Van-der-waals TM5 G 304 5x75 s9s10 K 167 N.s9s10.09
Hydrophobic C-term L 445 - S16 V 260 C.S16.04
Van-der-waals C-term L 445 - S16 V 260 C.S16.04
Ionic H8 R 393 8x47 s5s6 D 75 N.s5s6.04
Polar H8 R 393 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic H8 R 393 8x47 s5s6 D 75 N.s5s6.04
Van-der-waals H8 R 393 8x47 s5s6 D 75 N.s5s6.04
Polar ICL2 D 208 - S16 Y 258 C.S16.02
Hydrophobic TM6 A 316 6x25 s20c E 405 C.s20c.24
Van-der-waals TM6 A 316 6x25 s20c E 405 C.s20c.24
Hydrophobic TM5 G 305 5x76 s9s10 K 167 N.s9s10.09
Van-der-waals TM5 G 305 5x76 s9s10 K 167 N.s9s10.09
Polar TM6 R 320 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 R 320 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 R 320 6x29 s5s6 T 82 N.s5s6.11
Polar ICL2 A 187 - s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 A 187 - s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 A 187 - s15s16 Y 254 C.s15s16.03
Polar TM2 K 114 2x36 S16 Y 258 C.S16.02
Polar H8 E 395 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic H8 E 395 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 E 395 8x49 s5s6 E 74 N.s5s6.03
Ionic H8 K 398 8x52 s8s9 D 142 N.s8s9.06
Polar H8 K 398 8x52 s8s9 D 142 N.s8s9.06
Hydrophobic H8 K 398 8x52 s8s9 D 142 N.s8s9.06
Van-der-waals H8 K 398 8x52 s8s9 D 142 N.s8s9.06
Polar TM5 G 305 5x76 s9s10 E 164 N.s9s10.06
Hydrophobic C-term L 446 - S15 E 246 C.S15.09
Van-der-waals C-term L 446 - S15 E 246 C.S15.09
Hydrophobic TM6 V 331 6x40 s5s6 V 78 N.s5s6.07
Hydrophobic C-term L 463 - s10s11 G 189 C.s10s11.06
Polar TM6 V 324 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 324 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 V 324 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 V 324 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 V 324 6x33 s5s6 L 81 N.s5s6.10
Polar TM2 N 118 2x40 s5s6 D 75 N.s5s6.04
Hydrophobic C-term L 446 - S18 K 336 C.S18.10
Hydrophobic C-term L 445 - S16 K 261 C.S16.05
Van-der-waals C-term L 445 - S16 K 261 C.S16.05
Hydrophobic TM5 L 290 5x61 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 L 290 5x61 s5s6 I 79 N.s5s6.08
Polar H8 R 394 8x48 s8s9 Q 141 N.s8s9.05
Polar TM6 S 327 6x36 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 S 327 6x36 s5s6 V 78 N.s5s6.07
Van-der-waals TM6 S 327 6x36 s5s6 V 78 N.s5s6.07
Ionic C-term E 442 - s17s18 R 294 C.s17s18.10
Polar C-term E 442 - s17s18 R 294 C.s17s18.10
Hydrophobic C-term E 442 - s17s18 R 294 C.s17s18.10
Van-der-waals C-term E 442 - s17s18 R 294 C.s17s18.10
Hydrophobic TM3 R 180 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 180 3x50 s5s6 V 78 N.s5s6.07
Ionic H8 E 395 8x49 s8s9 K 145 N.s8s9.09
Polar H8 E 395 8x49 s8s9 K 145 N.s8s9.09
Hydrophobic H8 E 395 8x49 s8s9 K 145 N.s8s9.09
Van-der-waals H8 E 395 8x49 s8s9 K 145 N.s8s9.09
Polar C-term L 446 - S18 K 334 C.S18.08
Hydrophobic C-term L 446 - S18 K 334 C.S18.08
Van-der-waals C-term L 446 - S18 K 334 C.S18.08
Polar C-term Y 455 - S11 W 198 C.S11.05
Aromatic C-term Y 455 - S11 W 198 C.S11.05
Hydrophobic C-term Y 455 - S11 W 198 C.S11.05
Van-der-waals C-term Y 455 - S11 W 198 C.S11.05
Polar TM6 S 327 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 S 327 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic C-term Y 460 - S11 A 194 C.S11.01
Van-der-waals C-term Y 460 - S11 A 194 C.S11.01
Hydrophobic TM5 G 304 5x75 s9s10 E 164 N.s9s10.06
Van-der-waals TM5 G 304 5x75 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 V 328 6x37 s5s6 I 79 N.s5s6.08
Polar C-term Y 447 - S16 Y 258 C.S16.02
Hydrophobic C-term Y 447 - S16 Y 258 C.S16.02
Van-der-waals C-term Y 447 - S16 Y 258 C.S16.02
Polar C-term Y 460 - S19 E 354 C.S19.06
Hydrophobic C-term P 464 - s10s11 P 190 C.s10s11.07
Hydrophobic TM5 I 294 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 I 294 5x65 s5s6 L 81 N.s5s6.10
Polar TM6 R 320 6x29 s5s6 G 80 N.s5s6.09
Polar C-term S 467 - s17s18 E 318 C.s17s18.34
Van-der-waals H8 E 395 8x49 s5s6 D 75 N.s5s6.04