Beta-arrestin-1 - RXFP4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
RXFP4 76.2
Beta-arrestin-1 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 R 314 8x48 s5s6 D 67 N.s5s6.04
Hydrophobic H8 R 314 8x48 s5s6 D 67 N.s5s6.04
Van-der-waals H8 R 314 8x48 s5s6 D 67 N.s5s6.04
Hydrophobic ICL1 R 70 12x49 s8s9 P 133 N.s8s9.04
Van-der-waals ICL1 R 70 12x49 s8s9 P 133 N.s8s9.04
Hydrophobic TM6 S 247 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 L 312 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 312 7x56 s5s6 V 70 N.s5s6.07
Polar TM2 G 73 2x36 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 G 73 2x36 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 G 73 2x36 s8s9 T 136 N.s8s9.07
Polar ICL3 R 236 - s5s6 T 74 N.s5s6.11
Hydrophobic ICL3 R 236 - s5s6 T 74 N.s5s6.11
Van-der-waals ICL3 R 236 - s5s6 T 74 N.s5s6.11
Polar ICL1 A 71 12x50 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 A 71 12x50 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 A 71 12x50 s8s9 T 136 N.s8s9.07
Polar ICL1 P 72 12x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 P 72 12x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 P 72 12x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 R 139 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 139 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 231 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 L 231 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic H8 R 313 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 H 152 34x56 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 H 152 34x56 s15s16 T 246 C.s15s16.05
Ionic TM3 R 139 3x50 s5s6 D 69 N.s5s6.06
Polar TM3 R 139 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 R 139 3x50 s5s6 D 69 N.s5s6.06
Van-der-waals TM3 R 139 3x50 s5s6 D 69 N.s5s6.06
Polar TM6 S 247 6x36 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 149 34x53 s17s18 E 313 C.s17s18.39
Van-der-waals ICL2 P 149 34x53 s17s18 E 313 C.s17s18.39
Hydrophobic ICL1 R 70 12x49 s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 R 70 12x49 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 V 244 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 244 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 251 6x40 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 A 146 34x50 S6 F 75 N.S6.01
Van-der-waals ICL2 A 146 34x50 S6 F 75 N.S6.01
Polar ICL2 H 152 34x56 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 H 152 34x56 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 H 152 34x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 V 143 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 V 143 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL3 R 236 - S6 F 75 N.S6.01
Van-der-waals ICL3 R 236 - S6 F 75 N.S6.01
Ionic H8 E 315 8x49 s8s9 K 138 N.s8s9.09
Polar H8 E 315 8x49 s8s9 K 138 N.s8s9.09
Hydrophobic H8 E 315 8x49 s8s9 K 138 N.s8s9.09
Van-der-waals H8 E 315 8x49 s8s9 K 138 N.s8s9.09
Van-der-waals ICL3 R 236 - s5s6 L 73 N.s5s6.10
Hydrophobic TM5 L 227 5x61 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 L 227 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 142 3x53 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 V 142 3x53 s15s16 F 244 C.s15s16.03
Ionic H8 R 314 8x48 s20c E 405 C.s20c.15
Polar H8 R 314 8x48 s20c E 405 C.s20c.15
Van-der-waals H8 R 314 8x48 s20c E 405 C.s20c.15
Polar ICL2 H 152 34x56 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 H 152 34x56 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 H 152 34x56 s15s16 F 244 C.s15s16.03
Hydrophobic H8 R 313 8x47 s5s6 D 67 N.s5s6.04
Van-der-waals H8 R 313 8x47 s5s6 D 67 N.s5s6.04
Ionic H8 R 314 8x48 s5s6 E 66 N.s5s6.03
Polar H8 R 314 8x48 s5s6 E 66 N.s5s6.03
Hydrophobic H8 R 314 8x48 s5s6 E 66 N.s5s6.03
Van-der-waals H8 R 314 8x48 s5s6 E 66 N.s5s6.03
Polar H8 E 315 8x49 s5s6 D 67 N.s5s6.04
Hydrophobic H8 R 313 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 V 244 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 V 244 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 V 248 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 248 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 142 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 H 152 34x56 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 H 152 34x56 s15s16 L 243 C.s15s16.02
Hydrophobic ICL2 A 146 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 A 146 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic TM1 C 67 1x60 s8s9 T 136 N.s8s9.07
Hydrophobic TM7 L 308 7x52 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 308 7x52 s5s6 V 70 N.s5s6.07
Hydrophobic ICL1 A 71 12x50 s8s9 D 135 N.s8s9.06
Van-der-waals ICL1 A 71 12x50 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 A 147 34x51 S6 F 75 N.S6.01
Polar TM2 S 76 2x39 s5s6 L 68 N.s5s6.05
Van-der-waals TM6 R 237 6x26 S10 R 165 N.S10.03
Polar TM6 D 240 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM7 Y 309 7x53 s5s6 V 70 N.s5s6.07
Polar ICL1 A 71 12x50 s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 A 71 12x50 s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 A 71 12x50 s8s9 E 134 N.s8s9.05