ArrestinDb

Beta-arrestin-1 - RXFP4 complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
RXFP4	76.2
Beta-arrestin-1	79.8

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 19.8

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	H8	R	314	8x48	s5s6	D	67	N.s5s6.04
Hydrophobic	ICL1	R	70	12x49	s8s9	P	133	N.s8s9.04
Hydrophobic	TM6	S	247	6x36	s5s6	L	71	N.s5s6.08
Hydrophobic	TM7	L	312	7x56	s5s6	V	70	N.s5s6.07
Hydrophobic	TM2	G	73	2x36	s8s9	T	136	N.s8s9.07
Hydrophobic	ICL3	R	236	-	s5s6	T	74	N.s5s6.11
Hydrophobic	ICL1	A	71	12x50	s8s9	T	136	N.s8s9.07
Hydrophobic	ICL1	P	72	12x51	s8s9	T	136	N.s8s9.07
Hydrophobic	TM3	R	139	3x50	s5s6	V	70	N.s5s6.07
Hydrophobic	TM5	L	231	5x65	s5s6	L	73	N.s5s6.10
Hydrophobic	H8	R	313	8x47	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL2	H	152	34x56	s15s16	T	246	C.s15s16.05
Hydrophobic	TM3	R	139	3x50	s5s6	D	69	N.s5s6.06
Hydrophobic	ICL2	P	149	34x53	s17s18	E	313	C.s17s18.39
Hydrophobic	ICL1	R	70	12x49	s8s9	E	134	N.s8s9.05
Hydrophobic	TM6	V	244	6x33	s5s6	L	71	N.s5s6.08
Hydrophobic	TM6	L	251	6x40	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL2	A	146	34x50	S6	F	75	N.S6.01
Hydrophobic	ICL2	H	152	34x56	s15s16	N	245	C.s15s16.04
Hydrophobic	TM3	V	143	3x54	s5s6	L	73	N.s5s6.10
Hydrophobic	ICL3	R	236	-	S6	F	75	N.S6.01
Hydrophobic	H8	E	315	8x49	s8s9	K	138	N.s8s9.09
Hydrophobic	TM5	L	227	5x61	s5s6	L	71	N.s5s6.08
Hydrophobic	TM3	V	142	3x53	s15s16	F	244	C.s15s16.03
Hydrophobic	ICL2	H	152	34x56	s15s16	F	244	C.s15s16.03
Hydrophobic	H8	R	313	8x47	s5s6	D	67	N.s5s6.04
Hydrophobic	H8	R	314	8x48	s5s6	E	66	N.s5s6.03
Hydrophobic	H8	R	313	8x47	s5s6	D	69	N.s5s6.06
Hydrophobic	TM6	V	244	6x33	s5s6	L	73	N.s5s6.10
Hydrophobic	TM6	V	248	6x37	s5s6	L	71	N.s5s6.08
Hydrophobic	TM3	V	142	3x53	s5s6	L	68	N.s5s6.05
Hydrophobic	ICL2	H	152	34x56	s15s16	L	243	C.s15s16.02
Hydrophobic	ICL2	A	146	34x50	s15s16	F	244	C.s15s16.03
Hydrophobic	TM1	C	67	1x60	s8s9	T	136	N.s8s9.07
Hydrophobic	TM7	L	308	7x52	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL1	A	71	12x50	s8s9	D	135	N.s8s9.06
Hydrophobic	ICL2	A	147	34x51	S6	F	75	N.S6.01
Hydrophobic	TM7	Y	309	7x53	s5s6	V	70	N.s5s6.07
Hydrophobic	ICL1	A	71	12x50	s8s9	E	134	N.s8s9.05
Ionic	TM3	R	139	3x50	s5s6	D	69	N.s5s6.06
Ionic	H8	E	315	8x49	s8s9	K	138	N.s8s9.09
Ionic	H8	R	314	8x48	s20c	E	405	C.s20c.15
Ionic	H8	R	314	8x48	s5s6	E	66	N.s5s6.03
Polar	H8	R	314	8x48	s5s6	D	67	N.s5s6.04
Polar	TM2	G	73	2x36	s8s9	T	136	N.s8s9.07
Polar	ICL3	R	236	-	s5s6	T	74	N.s5s6.11
Polar	ICL1	A	71	12x50	s8s9	T	136	N.s8s9.07
Polar	ICL1	P	72	12x51	s8s9	T	136	N.s8s9.07
Polar	TM3	R	139	3x50	s5s6	D	69	N.s5s6.06
Polar	TM6	S	247	6x36	s5s6	V	70	N.s5s6.07
Polar	ICL2	H	152	34x56	s15s16	N	245	C.s15s16.04
Polar	H8	E	315	8x49	s8s9	K	138	N.s8s9.09
Polar	H8	R	314	8x48	s20c	E	405	C.s20c.15
Polar	ICL2	H	152	34x56	s15s16	F	244	C.s15s16.03
Polar	H8	R	314	8x48	s5s6	E	66	N.s5s6.03
Polar	H8	E	315	8x49	s5s6	D	67	N.s5s6.04
Polar	TM2	S	76	2x39	s5s6	L	68	N.s5s6.05
Polar	TM6	D	240	6x29	s5s6	T	74	N.s5s6.11
Polar	ICL1	A	71	12x50	s8s9	E	134	N.s8s9.05
Van-der-waals	H8	R	314	8x48	s5s6	D	67	N.s5s6.04
Van-der-waals	ICL1	R	70	12x49	s8s9	P	133	N.s8s9.04
Van-der-waals	TM7	L	312	7x56	s5s6	V	70	N.s5s6.07
Van-der-waals	TM2	G	73	2x36	s8s9	T	136	N.s8s9.07
Van-der-waals	ICL3	R	236	-	s5s6	T	74	N.s5s6.11
Van-der-waals	ICL1	A	71	12x50	s8s9	T	136	N.s8s9.07
Van-der-waals	ICL1	P	72	12x51	s8s9	T	136	N.s8s9.07
Van-der-waals	TM3	R	139	3x50	s5s6	V	70	N.s5s6.07
Van-der-waals	TM5	L	231	5x65	s5s6	L	73	N.s5s6.10
Van-der-waals	ICL2	H	152	34x56	s15s16	T	246	C.s15s16.05
Van-der-waals	TM3	R	139	3x50	s5s6	D	69	N.s5s6.06
Van-der-waals	ICL2	P	149	34x53	s17s18	E	313	C.s17s18.39
Van-der-waals	ICL1	R	70	12x49	s8s9	E	134	N.s8s9.05
Van-der-waals	TM6	V	244	6x33	s5s6	L	71	N.s5s6.08
Van-der-waals	ICL2	A	146	34x50	S6	F	75	N.S6.01
Van-der-waals	ICL2	H	152	34x56	s15s16	N	245	C.s15s16.04
Van-der-waals	TM3	V	143	3x54	s5s6	L	73	N.s5s6.10
Van-der-waals	ICL3	R	236	-	S6	F	75	N.S6.01
Van-der-waals	H8	E	315	8x49	s8s9	K	138	N.s8s9.09
Van-der-waals	ICL3	R	236	-	s5s6	L	73	N.s5s6.10
Van-der-waals	TM5	L	227	5x61	s5s6	L	71	N.s5s6.08
Van-der-waals	TM3	V	142	3x53	s15s16	F	244	C.s15s16.03
Van-der-waals	H8	R	314	8x48	s20c	E	405	C.s20c.15
Van-der-waals	ICL2	H	152	34x56	s15s16	F	244	C.s15s16.03
Van-der-waals	H8	R	313	8x47	s5s6	D	67	N.s5s6.04
Van-der-waals	H8	R	314	8x48	s5s6	E	66	N.s5s6.03
Van-der-waals	TM6	V	244	6x33	s5s6	L	73	N.s5s6.10
Van-der-waals	TM6	V	248	6x37	s5s6	L	71	N.s5s6.08
Van-der-waals	ICL2	H	152	34x56	s15s16	L	243	C.s15s16.02
Van-der-waals	ICL2	A	146	34x50	s15s16	F	244	C.s15s16.03
Van-der-waals	TM7	L	308	7x52	s5s6	V	70	N.s5s6.07
Van-der-waals	ICL1	A	71	12x50	s8s9	D	135	N.s8s9.06
Van-der-waals	TM6	R	237	6x26	S10	R	165	N.S10.03
Van-der-waals	ICL1	A	71	12x50	s8s9	E	134	N.s8s9.05

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Main reference

Beta-arrestin-1 - RXFP4 complex model Download Full