Beta-arrestin-2 - RXFP4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
RXFP4 75.4
Beta-arrestin-2 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 A 146 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 A 146 34x50 s15s16 S 246 C.s15s16.04
Polar ICL2 H 152 34x56 S5 Y 64 N.S5.12
Hydrophobic ICL2 H 152 34x56 S5 Y 64 N.S5.12
Van-der-waals ICL2 H 152 34x56 S5 Y 64 N.S5.12
Hydrophobic TM5 Y 224 5x58 s5s6 L 72 N.s5s6.08
Polar H8 R 314 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 314 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic ICL3 R 236 - s5s6 L 74 N.s5s6.10
Van-der-waals ICL3 R 236 - s5s6 L 74 N.s5s6.10
Hydrophobic H8 R 313 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 313 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 L 231 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 L 231 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 L 227 5x61 s5s6 L 72 N.s5s6.08
Polar ICL2 P 149 34x53 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 P 149 34x53 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 P 149 34x53 s15s16 T 247 C.s15s16.05
Hydrophobic TM6 V 244 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 P 72 12x51 s8s9 P 134 N.s8s9.04
Polar ICL2 G 148 34x52 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 G 148 34x52 s15s16 F 245 C.s15s16.03
Polar ICL2 H 152 34x56 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 H 152 34x56 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 H 152 34x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 V 143 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 H 152 34x56 s8s9 T 137 N.s8s9.07
Aromatic ICL3 R 236 - S6 F 76 N.S6.01
Hydrophobic ICL3 R 236 - S6 F 76 N.S6.01
Van-der-waals ICL3 R 236 - S6 F 76 N.S6.01
Hydrophobic TM6 R 237 6x26 S6 R 77 N.S6.02
Hydrophobic TM3 R 139 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 139 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 V 244 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 244 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 A 146 34x50 S6 F 76 N.S6.01
Hydrophobic TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 L 72 N.s5s6.08
Polar TM6 S 247 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 S 247 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 S 247 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 248 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 G 148 34x52 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 G 148 34x52 s15s16 S 246 C.s15s16.04
Hydrophobic ICL1 A 71 12x50 s5s6 R 66 N.s5s6.02
Van-der-waals ICL1 A 71 12x50 s5s6 R 66 N.s5s6.02
Polar ICL1 P 72 12x51 s5s6 R 66 N.s5s6.02
Van-der-waals ICL1 P 72 12x51 s5s6 R 66 N.s5s6.02
Hydrophobic TM2 P 74 2x37 s8s9 K 139 N.s8s9.09
Van-der-waals TM2 P 74 2x37 s8s9 K 139 N.s8s9.09
Hydrophobic TM3 V 142 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 142 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 A 146 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL3 R 236 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 R 236 - s15s16 F 245 C.s15s16.03
Polar ICL2 G 148 34x52 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 G 148 34x52 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 G 148 34x52 s15s16 T 247 C.s15s16.05
Polar ICL3 R 236 - s5s6 S 75 N.s5s6.11
Hydrophobic TM3 V 142 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 A 146 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 A 146 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 V 143 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 143 3x54 S6 F 76 N.S6.01
Polar ICL2 A 147 34x51 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 A 147 34x51 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 A 147 34x51 s15s16 F 245 C.s15s16.03
Ionic TM6 R 237 6x26 S6 D 79 N.S6.04
Polar TM6 R 237 6x26 S6 D 79 N.S6.04
Hydrophobic TM6 R 237 6x26 S6 D 79 N.S6.04
Van-der-waals TM6 R 237 6x26 S6 D 79 N.S6.04
Hydrophobic TM6 L 251 6x40 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 L 251 6x40 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 H 152 34x56 s8s9 G 138 N.s8s9.08
Hydrophobic TM4 S 154 4x38 s8s9 T 137 N.s8s9.07
Hydrophobic H8 E 315 8x49 s5s6 D 68 N.s5s6.04
Van-der-waals H8 E 315 8x49 s5s6 D 68 N.s5s6.04