Arrestin-C - RXFP4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
RXFP4 75.5
Arrestin-C 81.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 142 3x53 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 V 142 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 R 234 5x68 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 R 234 5x68 s15s16 S 242 C.s15s16.04
Polar TM3 M 145 3x56 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 M 145 3x56 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 M 145 3x56 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 Y 224 5x58 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 Y 224 5x58 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 R 237 6x26 S6 K 73 N.S6.03
Van-der-waals TM6 R 237 6x26 S6 K 73 N.S6.03
Hydrophobic TM6 R 237 6x26 s17s18 L 311 C.s17s18.40
Van-der-waals TM6 R 237 6x26 s17s18 L 311 C.s17s18.40
Polar ICL2 H 152 34x56 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 H 152 34x56 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 H 152 34x56 s8s9 K 135 N.s8s9.09
Hydrophobic TM2 P 74 2x37 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 P 74 2x37 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 A 146 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 A 146 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 S 247 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 S 247 6x36 s5s6 I 67 N.s5s6.08
Polar TM3 V 142 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 V 142 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic ICL1 A 71 12x50 s9s10 K 157 N.s9s10.12
Van-der-waals ICL1 A 71 12x50 s9s10 K 157 N.s9s10.12
Ionic TM6 R 237 6x26 s17s18 E 310 C.s17s18.39
Polar TM6 R 237 6x26 s17s18 E 310 C.s17s18.39
Hydrophobic TM3 R 139 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 139 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 L 231 5x65 s5s6 L 69 N.s5s6.10
Van-der-waals TM5 L 231 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 V 143 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 V 143 3x54 S6 F 71 N.S6.01
Polar ICL2 P 149 34x53 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 P 149 34x53 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 P 149 34x53 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 V 142 3x53 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 V 142 3x53 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 P 149 34x53 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 P 149 34x53 s8s9 D 132 N.s8s9.06
Ionic H8 R 325 8x59 s9s10 E 149 N.s9s10.01
Hydrophobic TM6 L 251 6x40 s5s6 I 67 N.s5s6.08
Hydrophobic ICL3 Q 235 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL3 Q 235 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 A 147 34x51 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 A 147 34x51 s8s9 A 133 N.s8s9.07
Hydrophobic TM3 V 143 3x54 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 V 143 3x54 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 P 149 34x53 s8s9 E 131 N.s8s9.05
Hydrophobic TM3 R 139 3x50 s5s6 V 66 N.s5s6.07
Polar ICL2 H 152 34x56 s5s6 R 61 N.s5s6.02
Aromatic ICL2 H 152 34x56 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 H 152 34x56 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 H 152 34x56 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 R 234 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 234 5x68 s15s16 Y 241 C.s15s16.03
Ionic H8 R 325 8x59 s9s10 E 153 N.s9s10.08
Polar H8 R 325 8x59 s9s10 E 153 N.s9s10.08
Van-der-waals H8 R 325 8x59 s9s10 E 153 N.s9s10.08
Ionic TM6 R 237 6x26 s17s18 D 308 C.s17s18.37
Polar TM6 R 237 6x26 s17s18 D 308 C.s17s18.37
Hydrophobic TM6 V 244 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 V 244 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic ICL3 Q 235 - s5s6 L 69 N.s5s6.10
Van-der-waals ICL3 Q 235 - s5s6 L 69 N.s5s6.10
Polar ICL2 A 147 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 A 147 34x51 s8s9 G 134 N.s8s9.08
Ionic ICL3 R 236 - s17s18 E 310 C.s17s18.39
Polar ICL3 R 236 - s17s18 E 310 C.s17s18.39
Hydrophobic ICL3 R 236 - s17s18 E 310 C.s17s18.39
Van-der-waals ICL3 R 236 - s17s18 E 310 C.s17s18.39
Hydrophobic TM6 D 240 6x29 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 A 146 34x50 s5s6 L 64 N.s5s6.05
Hydrophobic ICL2 A 146 34x50 S6 F 71 N.S6.01
Hydrophobic TM5 L 227 5x61 s5s6 I 67 N.s5s6.08
Van-der-waals TM5 L 227 5x61 s5s6 I 67 N.s5s6.08
Polar ICL2 A 146 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 A 146 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 A 146 34x50 S5 Y 59 N.S5.12
Polar H8 Q 318 8x52 s9s10 T 154 N.s9s10.09
Hydrophobic H8 Q 318 8x52 s9s10 T 154 N.s9s10.09
Van-der-waals H8 Q 318 8x52 s9s10 T 154 N.s9s10.09
Polar TM5 R 234 5x68 S5 Y 59 N.S5.12
Van-der-waals TM5 R 234 5x68 S5 Y 59 N.S5.12
Ionic H8 R 313 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 313 8x47 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 313 8x47 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 V 248 6x37 s5s6 I 67 N.s5s6.08
Polar ICL2 G 148 34x52 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 G 148 34x52 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 G 148 34x52 s8s9 A 133 N.s8s9.07
Ionic TM5 R 234 5x68 S16 D 244 C.S16.01
Polar TM5 R 234 5x68 S16 D 244 C.S16.01
Hydrophobic TM5 R 234 5x68 S16 D 244 C.S16.01
Van-der-waals TM5 R 234 5x68 S16 D 244 C.S16.01
Polar H8 R 314 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 314 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic ICL1 R 70 12x49 s9s10 S 156 N.s9s10.11