Gi1 - RXFP4 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-05-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
RXFP4 78.2
Gαi1 88.6
Gβ1 91.5
Gγ2 79.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 143 3x54 G.H5 I 344 G.H5.16
Polar TM6 R 237 6x26 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 V 244 6x33 G.H5 L 348 G.H5.20
Polar TM5 R 234 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM5 R 234 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 234 5x68 G.H5 T 340 G.H5.12
Hydrophobic TM6 V 248 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 251 6x40 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 251 6x40 G.H5 L 353 G.H5.25
Hydrophobic C-term L 365 - G.H3 S 252 G.H3.11
Hydrophobic TM3 V 143 3x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 A 146 34x50 G.H5 T 340 G.H5.12
Polar H8 R 313 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 R 313 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 R 313 8x47 G.H5 D 350 G.H5.22
Hydrophobic ICL2 H 152 34x56 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 V 143 3x54 G.H5 L 348 G.H5.20
Polar TM3 V 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 V 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 A 146 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 227 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 L 227 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM6 D 240 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 D 240 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 V 244 6x33 G.H5 L 353 G.H5.25
Polar TM6 S 247 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 247 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 247 6x36 G.H5 L 353 G.H5.25
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM4 L 155 4x39 G.HN R 24 G.HN.48
Van-der-waals TM4 L 155 4x39 G.HN R 24 G.HN.48
Hydrophobic TM3 R 139 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 243 6x32 G.H5 F 354 G.H5.26
Hydrophobic ICL2 A 146 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 146 34x50 G.H5 I 343 G.H5.15
Hydrophobic H8 R 313 8x47 G.H5 C 351 G.H5.23
Hydrophobic C-term L 365 - G.H2 W 211 G.H2.07
Hydrophobic TM5 F 230 5x64 G.H5 I 344 G.H5.16
Hydrophobic C-term L 368 - G.H2 I 212 G.H2.08
Van-der-waals C-term L 368 - G.H2 I 212 G.H2.08
Hydrophobic H8 R 313 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 R 313 8x47 G.H5 G 352 G.H5.24
Hydrophobic C-term L 365 - G.H3 I 253 G.H3.12
Hydrophobic TM5 L 227 5x61 G.H5 L 348 G.H5.20
Ionic TM5 R 234 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 234 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 234 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 A 147 34x51 G.H5 I 344 G.H5.16
Ionic C-term R 360 - G.s4h3 E 239 G.s4h3.13
Polar C-term R 360 - G.s4h3 E 239 G.s4h3.13
Van-der-waals C-term R 360 - G.s4h3 E 239 G.s4h3.13
Hydrophobic C-term L 368 - G.h2s4 F 215 G.h2s4.01
Van-der-waals C-term L 368 - G.h2s4 F 215 G.h2s4.01
Hydrophobic TM5 R 234 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 234 5x68 G.H5 I 344 G.H5.16
Hydrophobic C-term G 371 - G.H3 W 258 G.H3.17
Van-der-waals C-term G 371 - G.H3 W 258 G.H3.17
Hydrophobic ICL3 R 236 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 R 236 - G.H5 K 345 G.H5.17
Hydrophobic ICL2 A 146 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 A 147 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 A 147 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 P 149 34x53 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 P 149 34x53 G.s2s3 D 193 G.s2s3.02
Polar C-term D 369 - G.H3 N 256 G.H3.15
Hydrophobic C-term D 369 - G.H3 N 256 G.H3.15
Van-der-waals C-term D 369 - G.H3 N 256 G.H3.15
Hydrophobic TM6 V 244 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM5 Y 224 5x58 G.H5 L 353 G.H5.25
Ionic ICL3 R 236 - G.H5 D 341 G.H5.13
Polar ICL3 R 236 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 236 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 236 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 236 - G.H5 L 348 G.H5.20
Van-der-waals ICL3 R 236 - G.H5 L 348 G.H5.20
Hydrophobic C-term L 365 - G.H2 R 208 G.H2.04
Hydrophobic TM5 L 231 5x65 G.H5 L 348 G.H5.20
Ionic TM6 D 240 6x29 G.H5 K 345 G.H5.17
Polar TM6 D 240 6x29 G.H5 K 345 G.H5.17
Hydrophobic TM6 D 240 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 D 240 6x29 G.H5 K 345 G.H5.17
Hydrophobic C-term L 365 - G.H3 L 249 G.H3.08
Van-der-waals C-term L 365 - G.H3 L 249 G.H3.08
Ionic TM6 R 237 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 237 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 237 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 237 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 236 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 R 236 - G.H5 I 344 G.H5.16
Hydrophobic TM5 L 231 5x65 G.H5 I 344 G.H5.16