Arrestin-C - RXFP1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
RXFP1 77.7
Arrestin-C 76.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Van-der-waals ICL2 F 518 34x51 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 F 630 6x37 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 F 630 6x37 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 F 630 6x37 S6 F 71 N.S6.01
Hydrophobic TM6 N 618 6x25 S6 V 77 N.S6.07
Ionic TM6 K 621 6x28 s9s10 E 152 N.s9s10.07
Polar TM6 K 621 6x28 s9s10 E 152 N.s9s10.07
Hydrophobic TM6 K 621 6x28 s9s10 E 152 N.s9s10.07
Van-der-waals TM6 K 621 6x28 s9s10 E 152 N.s9s10.07
Hydrophobic H8 Y 697 8x59 s1s2 N 11 N.s1s2.03
Van-der-waals H8 Y 697 8x59 s1s2 N 11 N.s1s2.03
Hydrophobic TM6 I 616 6x23 S6 D 74 N.S6.04
Van-der-waals TM6 I 616 6x23 S6 D 74 N.S6.04
Hydrophobic ICL2 R 522 34x55 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 R 522 34x55 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 I 616 6x23 S6 L 75 N.S6.05
Van-der-waals TM6 I 616 6x23 S6 L 75 N.S6.05
Polar ICL2 P 517 34x50 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 P 517 34x50 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 P 517 34x50 s8s9 G 134 N.s8s9.08
Hydrophobic ICL1 E 436 12x50 s5s6 V 66 N.s5s6.07
Van-der-waals ICL1 E 436 12x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 F 518 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 F 518 34x51 S5 Y 59 N.S5.12
Aromatic H8 Y 697 8x59 s9s10 R 158 N.s9s10.13
Hydrophobic H8 Y 697 8x59 s9s10 R 158 N.s9s10.13
Van-der-waals H8 Y 697 8x59 s9s10 R 158 N.s9s10.13
Polar ICL2 C 520 34x53 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 C 520 34x53 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 C 520 34x53 s8s9 A 133 N.s8s9.07
Hydrophobic TM5 A 613 5x72 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 A 613 5x72 s17s18 L 311 C.s17s18.40
Van-der-waals ICL1 N 437 12x51 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 R 522 34x55 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 R 522 34x55 s8s9 K 135 N.s8s9.09
Hydrophobic ICL1 E 436 12x50 s5s6 D 63 N.s5s6.04
Hydrophobic ICL1 N 437 12x51 s5s6 D 63 N.s5s6.04
Van-der-waals ICL1 N 437 12x51 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 A 610 5x69 S6 K 73 N.S6.03
Hydrophobic H8 T 685 8x47 s5s6 V 66 N.s5s6.07
Van-der-waals H8 T 685 8x47 s5s6 V 66 N.s5s6.07
Polar ICL2 P 517 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 P 517 34x50 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 P 517 34x50 s8s9 K 135 N.s8s9.09
Hydrophobic ICL2 P 517 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 517 34x50 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 A 613 5x72 S6 L 75 N.S6.05
Van-der-waals TM5 A 613 5x72 S6 L 75 N.S6.05
Hydrophobic TM5 V 606 5x65 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 V 606 5x65 s15s16 Y 241 C.s15s16.03
Polar TM6 R 629 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 R 629 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 R 629 6x36 s5s6 I 67 N.s5s6.08
Hydrophobic H8 P 687 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic ICL2 F 518 34x51 S9 C 137 N.S9.01
Van-der-waals ICL2 F 518 34x51 S9 C 137 N.S9.01
Polar TM5 T 612 5x71 s17s18 L 311 C.s17s18.40
Hydrophobic TM5 T 612 5x71 s17s18 L 311 C.s17s18.40
Van-der-waals TM5 T 612 5x71 s17s18 L 311 C.s17s18.40
Polar TM5 S 609 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 S 609 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 S 609 5x68 s15s16 Y 241 C.s15s16.03
Polar TM5 T 612 5x71 S6 K 73 N.S6.03
Hydrophobic TM5 T 612 5x71 S6 K 73 N.S6.03
Van-der-waals TM5 T 612 5x71 S6 K 73 N.S6.03
Hydrophobic ICL2 F 518 34x51 s8s9 K 135 N.s8s9.09
Van-der-waals ICL2 F 518 34x51 s8s9 K 135 N.s8s9.09
Hydrophobic TM5 S 609 5x68 s15s16 L 240 C.s15s16.02
Polar ICL2 C 520 34x53 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 C 520 34x53 s8s9 G 134 N.s8s9.08
Hydrophobic TM3 I 514 3x54 s5s6 L 69 N.s5s6.10
Van-der-waals TM3 I 514 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 P 517 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 517 34x50 S5 Y 59 N.S5.12
Ionic ICL2 R 519 34x52 S16 D 244 C.S16.01
Hydrophobic ICL2 P 517 34x50 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 P 517 34x50 s8s9 A 133 N.s8s9.07
Hydrophobic TM5 T 612 5x71 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 T 612 5x71 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 A 613 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 A 613 5x72 S6 K 73 N.S6.03
Hydrophobic ICL2 F 518 34x51 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 F 518 34x51 s8s9 G 134 N.s8s9.08
Hydrophobic TM2 Y 440 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM5 V 606 5x65 S6 F 71 N.S6.01
Van-der-waals TM5 V 606 5x65 S6 F 71 N.S6.01
Hydrophobic H8 P 687 8x49 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 F 518 34x51 S16 D 244 C.S16.01
Van-der-waals ICL2 F 518 34x51 S16 D 244 C.S16.01
Hydrophobic TM3 I 514 3x54 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 I 514 3x54 s8s9 K 135 N.s8s9.09
Ionic H8 E 690 8x52 s9s10 K 157 N.s9s10.12
Polar H8 E 690 8x52 s9s10 K 157 N.s9s10.12
Hydrophobic H8 E 690 8x52 s9s10 K 157 N.s9s10.12
Van-der-waals H8 E 690 8x52 s9s10 K 157 N.s9s10.12
Hydrophobic TM6 Q 619 6x26 S6 K 73 N.S6.03
Van-der-waals TM6 Q 619 6x26 S6 K 73 N.S6.03
Hydrophobic ICL2 R 522 34x55 s8s9 P 136 N.s8s9.10
Van-der-waals ICL2 R 522 34x55 s8s9 P 136 N.s8s9.10
Hydrophobic TM6 K 622 6x29 S6 R 72 N.S6.02
Van-der-waals TM6 K 622 6x29 S6 R 72 N.S6.02
Polar ICL2 R 519 34x52 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 R 519 34x52 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 R 519 34x52 s8s9 A 133 N.s8s9.07
Hydrophobic TM6 I 616 6x23 S6 Y 76 N.S6.06
Van-der-waals TM6 I 616 6x23 S6 Y 76 N.S6.06
Hydrophobic TM6 R 629 6x36 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 R 629 6x36 s5s6 G 68 N.s5s6.09
Polar TM5 S 605 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 S 605 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 S 605 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 F 518 34x51 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 F 518 34x51 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 C 520 34x53 s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 C 520 34x53 s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 F 518 34x51 S8 L 126 N.S8.03
Polar ICL2 C 520 34x53 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 C 520 34x53 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 C 520 34x53 s8s9 E 131 N.s8s9.05
Hydrophobic TM3 K 510 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 K 510 3x50 s5s6 I 67 N.s5s6.08
Polar ICL1 R 434 12x48 s20c V 380 C.s20c.13
Aromatic ICL2 F 518 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 F 518 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 F 518 34x51 S16 Y 246 C.S16.03
Hydrophobic TM3 V 515 3x55 s15s16 S 242 C.s15s16.04
Van-der-waals TM3 V 515 3x55 s15s16 S 242 C.s15s16.04
Polar TM5 S 609 5x68 S6 K 73 N.S6.03
Hydrophobic TM5 S 609 5x68 S6 K 73 N.S6.03
Van-der-waals TM5 S 609 5x68 S6 K 73 N.S6.03
Polar TM6 R 629 6x36 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 R 629 6x36 s5s6 V 66 N.s5s6.07
Van-der-waals TM6 R 629 6x36 s5s6 V 66 N.s5s6.07
Polar H8 R 694 8x56 s9s10 R 158 N.s9s10.13
Hydrophobic H8 R 694 8x56 s9s10 R 158 N.s9s10.13
Van-der-waals H8 R 694 8x56 s9s10 R 158 N.s9s10.13
Hydrophobic TM2 Y 440 2x39 s5s6 I 67 N.s5s6.08
Van-der-waals TM2 Y 440 2x39 s5s6 I 67 N.s5s6.08
Ionic H8 R 686 8x48 s5s6 E 65 N.s5s6.06
Polar H8 R 686 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic H8 R 686 8x48 s5s6 E 65 N.s5s6.06
Van-der-waals H8 R 686 8x48 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 I 616 6x23 S6 V 77 N.S6.07
Hydrophobic ICL2 F 518 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 F 518 34x51 S15 V 238 C.S15.14
Polar TM6 Q 619 6x26 S6 D 74 N.S6.04
Van-der-waals TM6 Q 619 6x26 S6 D 74 N.S6.04
Polar TM6 E 623 6x30 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 E 623 6x30 s15s16 Y 241 C.s15s16.03
Polar H8 R 686 8x48 S10 Y 160 N.S10.01
Polar TM3 I 514 3x54 S5 Y 59 N.S5.12
Hydrophobic TM3 I 514 3x54 S5 Y 59 N.S5.12
Van-der-waals TM3 I 514 3x54 S5 Y 59 N.S5.12
Hydrophobic TM6 L 626 6x33 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 L 626 6x33 s5s6 T 70 N.s5s6.11
Polar H8 N 698 8x60 s9s10 R 158 N.s9s10.13
Hydrophobic H8 N 698 8x60 s9s10 R 158 N.s9s10.13
Van-der-waals H8 N 698 8x60 s9s10 R 158 N.s9s10.13
Polar TM3 C 513 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 C 513 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 C 513 3x53 s8s9 K 135 N.s8s9.09
Polar ICL2 R 522 34x55 s8s9 G 134 N.s8s9.08
Hydrophobic ICL2 R 522 34x55 s8s9 G 134 N.s8s9.08
Van-der-waals ICL2 R 522 34x55 s8s9 G 134 N.s8s9.08
Ionic TM6 K 622 6x29 S6 D 74 N.S6.04
Polar TM6 K 622 6x29 S6 D 74 N.S6.04
Hydrophobic TM6 K 622 6x29 S6 D 74 N.S6.04
Van-der-waals TM6 K 622 6x29 S6 D 74 N.S6.04
Hydrophobic TM3 K 510 3x50 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 C 513 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM3 I 514 3x54 S6 F 71 N.S6.01
Van-der-waals TM3 I 514 3x54 S6 F 71 N.S6.01
Polar ICL2 C 520 34x53 s8s9 D 132 N.s8s9.06
Hydrophobic ICL2 C 520 34x53 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 C 520 34x53 s8s9 D 132 N.s8s9.06
Hydrophobic TM6 E 623 6x30 S6 K 73 N.S6.03
Hydrophobic TM6 L 626 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 L 626 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM6 L 626 6x33 S6 F 71 N.S6.01