Beta-arrestin-2 - RXFP2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
RXFP2 77.0
Beta-arrestin-2 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.6
PAE mean: 17.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 Q 622 5x71 S6 K 78 N.S6.03
Hydrophobic TM5 Q 622 5x71 S6 K 78 N.S6.03
Van-der-waals TM5 Q 622 5x71 S6 K 78 N.S6.03
Polar TM6 R 639 6x36 s5s6 D 70 N.s5s6.06
Van-der-waals TM6 R 639 6x36 s5s6 D 70 N.s5s6.06
Hydrophobic TM3 I 524 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 524 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 K 520 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 E 446 12x50 s5s6 E 67 N.s5s6.03
Van-der-waals ICL1 E 446 12x50 s5s6 E 67 N.s5s6.03
Hydrophobic TM2 T 449 2x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM2 T 449 2x38 s8s9 E 135 N.s8s9.05
Polar ICL1 K 444 12x48 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 444 12x48 s20c Y 404 C.s20c.14
Hydrophobic TM3 K 520 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 K 520 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 V 636 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM2 H 450 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 H 450 2x39 s5s6 V 71 N.s5s6.07
Polar ICL2 P 527 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 527 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 527 34x50 S5 Y 64 N.S5.12
Ionic ICL2 R 532 34x55 s5s6 D 68 N.s5s6.04
Polar ICL2 R 532 34x55 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 532 34x55 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 532 34x55 s5s6 D 68 N.s5s6.04
Hydrophobic H8 F 697 8x49 s20c Y 404 C.s20c.14
Van-der-waals H8 F 697 8x49 s20c Y 404 C.s20c.14
Polar TM4 K 535 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 K 535 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 K 535 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 V 523 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 F 528 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 F 528 34x51 S16 A 248 C.S16.01
Hydrophobic TM5 T 623 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 T 623 5x72 S6 K 78 N.S6.03
Aromatic ICL2 F 528 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 F 528 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 F 528 34x51 S5 Y 64 N.S5.12
Polar ICL2 P 527 34x50 s5s6 R 66 N.s5s6.02
Polar TM6 R 639 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 R 639 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 R 639 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 F 528 34x51 S9 C 141 N.S9.01
Van-der-waals ICL2 F 528 34x51 S9 C 141 N.S9.01
Hydrophobic TM3 V 523 3x53 s5s6 R 66 N.s5s6.02
Ionic ICL2 R 532 34x55 s8s9 D 136 N.s8s9.06
Polar ICL2 R 532 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic ICL2 R 532 34x55 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 R 532 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic TM5 T 619 5x68 S6 F 76 N.S6.01
Van-der-waals TM5 T 619 5x68 S6 F 76 N.S6.01
Hydrophobic TM5 T 619 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 T 619 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 T 623 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 T 623 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic TM4 G 534 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 G 534 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 I 616 5x65 S6 F 76 N.S6.01
Hydrophobic ICL2 F 528 34x51 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 F 528 34x51 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 524 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 524 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM6 V 636 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 I 616 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 I 616 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 527 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 527 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic H8 T 695 8x47 s5s6 V 71 N.s5s6.07
Polar ICL2 F 528 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 F 528 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 F 528 34x51 S16 Y 250 C.S16.03
Hydrophobic TM6 F 640 6x37 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 Y 691 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic ICL1 E 446 12x50 s20c Y 404 C.s20c.14
Van-der-waals ICL1 E 446 12x50 s20c Y 404 C.s20c.14
Polar ICL1 N 447 12x51 s5s6 D 68 N.s5s6.04
Hydrophobic ICL1 N 447 12x51 s5s6 D 68 N.s5s6.04
Van-der-waals ICL1 N 447 12x51 s5s6 D 68 N.s5s6.04
Polar H8 K 701 8x53 s20c Y 404 C.s20c.14
Van-der-waals H8 K 701 8x53 s20c Y 404 C.s20c.14
Polar ICL1 N 447 12x51 s8s9 T 137 N.s8s9.07
Polar ICL2 S 529 34x52 s5s6 R 66 N.s5s6.02
Polar TM5 Q 622 5x71 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 Q 622 5x71 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 Q 622 5x71 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 F 528 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 F 528 34x51 S15 I 242 C.S15.14
Hydrophobic TM6 R 639 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 F 640 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 F 640 6x37 s5s6 L 72 N.s5s6.08
Polar ICL1 E 446 12x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 E 446 12x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 E 446 12x50 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 I 524 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 R 532 34x55 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 532 34x55 s5s6 R 66 N.s5s6.02
Polar TM3 V 523 3x53 S5 Y 64 N.S5.12
Hydrophobic ICL2 N 530 34x53 S16 Y 250 C.S16.03
Van-der-waals ICL2 N 530 34x53 S16 Y 250 C.S16.03
Hydrophobic TM6 I 643 6x40 s5s6 L 72 N.s5s6.08
Polar TM6 R 632 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 R 632 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM5 T 623 5x72 S6 F 76 N.S6.01
Hydrophobic TM5 T 623 5x72 S6 R 77 N.S6.02
Van-der-waals TM5 T 623 5x72 S6 R 77 N.S6.02