Beta-arrestin-1 - S1P1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
S1P1 74.6
Beta-arrestin-1 81.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 H 152 34x53 s8s9 P 131 N.s8s9.02
Van-der-waals H8 N 315 8x47 s5s6 V 70 N.s5s6.07
Polar ICL2 N 153 34x54 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 N 153 34x54 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 N 153 34x54 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 H 152 34x53 S8 L 129 N.S8.03
Van-der-waals ICL2 H 152 34x53 S8 L 129 N.S8.03
Hydrophobic ICL2 M 149 34x50 S6 F 75 N.S6.01
Hydrophobic ICL2 L 151 34x52 S15 I 241 C.S15.14
Van-der-waals ICL2 L 151 34x52 S15 I 241 C.S15.14
Hydrophobic ICL3 F 237 - s17s18 I 314 C.s17s18.40
Van-der-waals ICL3 F 237 - s17s18 I 314 C.s17s18.40
Ionic ICL2 H 152 34x53 s8s9 D 135 N.s8s9.06
Polar ICL2 H 152 34x53 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 H 152 34x53 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 H 152 34x53 s8s9 D 135 N.s8s9.06
Hydrophobic TM2 M 80 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 M 80 2x39 s5s6 V 70 N.s5s6.07
Polar TM5 L 235 5x72 S6 K 77 N.S6.03
Hydrophobic TM5 L 235 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 L 235 5x72 S6 K 77 N.S6.03
Hydrophobic ICL2 K 150 34x51 S5 Y 63 N.S5.12
Hydrophobic TM5 I 224 5x61 s5s6 L 71 N.s5s6.08
Polar TM3 K 148 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 K 148 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 K 148 3x56 s15s16 N 245 C.s15s16.04
Polar TM2 R 78 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 R 78 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 R 78 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 L 235 5x72 S6 F 75 N.S6.01
Hydrophobic TM5 L 235 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 235 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic ICL3 F 237 - S6 K 77 N.S6.03
Van-der-waals ICL3 F 237 - S6 K 77 N.S6.03
Hydrophobic TM3 M 146 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 M 146 3x54 s5s6 L 68 N.s5s6.05
Polar ICL3 K 243 - S5 T 58 N.S5.07
Van-der-waals ICL3 K 243 - S5 T 58 N.S5.07
Polar ICL1 K 75 12x49 s20c K 403 C.s20c.13
Van-der-waals ICL1 K 75 12x49 s20c K 403 C.s20c.13
Hydrophobic TM3 T 145 3x53 s5s6 L 68 N.s5s6.05
Polar TM2 R 78 2x37 s8s9 E 134 N.s8s9.05
Hydrophobic TM2 R 78 2x37 s8s9 E 134 N.s8s9.05
Van-der-waals TM2 R 78 2x37 s8s9 E 134 N.s8s9.05
Polar TM3 R 142 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 R 142 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 142 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 H 152 34x53 s8s9 G 132 N.s8s9.03
Hydrophobic ICL2 H 152 34x53 s8s9 G 132 N.s8s9.03
Van-der-waals ICL2 H 152 34x53 s8s9 G 132 N.s8s9.03
Hydrophobic TM5 V 228 5x65 S6 F 75 N.S6.01
Polar TM3 T 145 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 T 145 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 T 145 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 151 34x52 S16 A 247 C.S16.01
Hydrophobic ICL2 L 151 34x52 S8 L 129 N.S8.03
Polar TM5 R 234 5x71 S6 K 77 N.S6.03
Ionic H8 K 316 8x48 s20c E 407 C.s20c.17
Polar H8 K 316 8x48 s20c E 407 C.s20c.17
Hydrophobic ICL1 K 75 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 T 145 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 T 145 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 M 146 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 151 34x52 S5 Y 63 N.S5.12
Van-der-waals ICL2 L 151 34x52 S5 Y 63 N.S5.12
Hydrophobic TM5 V 228 5x65 s5s6 L 73 N.s5s6.10
Van-der-waals TM5 V 228 5x65 s5s6 L 73 N.s5s6.10
Polar TM6 K 250 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 K 250 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 K 250 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM3 M 146 3x54 S6 F 75 N.S6.01
Polar ICL2 H 152 34x53 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 H 152 34x53 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 H 152 34x53 s5s6 R 65 N.s5s6.02
Polar ICL2 M 149 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 M 149 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 M 149 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 M 149 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 M 149 34x50 s15s16 F 244 C.s15s16.03
Polar ICL2 M 149 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 M 149 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 M 149 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 M 146 3x54 s5s6 L 71 N.s5s6.08
Polar ICL2 H 152 34x53 S16 Y 249 C.S16.03
Aromatic ICL2 H 152 34x53 S16 Y 249 C.S16.03
Hydrophobic ICL2 H 152 34x53 S16 Y 249 C.S16.03
Van-der-waals ICL2 H 152 34x53 S16 Y 249 C.S16.03
Polar ICL2 N 153 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 N 153 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic TM2 I 84 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 R 78 2x37 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 R 142 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 L 151 34x52 S9 C 140 N.S9.01
Van-der-waals ICL2 L 151 34x52 S9 C 140 N.S9.01
Hydrophobic ICL3 K 243 - S6 V 81 N.S6.07
Van-der-waals ICL3 K 243 - S6 V 81 N.S6.07
Hydrophobic TM6 K 250 6x29 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 K 250 6x29 s5s6 L 73 N.s5s6.10
Polar ICL2 H 152 34x53 s8s9 Q 130 N.s8s9.01
Hydrophobic ICL2 H 152 34x53 s8s9 Q 130 N.s8s9.01
Van-der-waals ICL2 H 152 34x53 s8s9 Q 130 N.s8s9.01
Hydrophobic ICL2 H 152 34x53 s17s18 R 285 C.s17s18.11
Ionic ICL3 K 243 - S6 D 78 N.S6.04
Polar ICL3 K 243 - S6 D 78 N.S6.04
Hydrophobic ICL3 K 243 - S6 D 78 N.S6.04
Van-der-waals ICL3 K 243 - S6 D 78 N.S6.04
Hydrophobic TM6 L 254 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 254 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 235 5x72 s15s16 L 243 C.s15s16.02
Van-der-waals TM5 L 235 5x72 s15s16 L 243 C.s15s16.02
Polar ICL2 K 150 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 K 150 34x51 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 150 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 L 254 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 254 6x33 s5s6 L 73 N.s5s6.10
Ionic H8 R 320 8x52 s20c E 405 C.s20c.15
Polar H8 R 320 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 R 320 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 R 320 8x52 s20c E 405 C.s20c.15
Polar ICL2 H 152 34x53 s17s18 G 286 C.s17s18.12
Hydrophobic ICL2 H 152 34x53 s17s18 G 286 C.s17s18.12
Van-der-waals ICL2 H 152 34x53 s17s18 G 286 C.s17s18.12
Polar ICL2 L 151 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 L 151 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 L 151 34x52 S16 Y 249 C.S16.03
Polar ICL2 L 151 34x52 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 L 151 34x52 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 L 151 34x52 s5s6 R 65 N.s5s6.02
Polar ICL2 N 153 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 N 153 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 N 153 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic H8 E 317 8x49 s5s6 E 66 N.s5s6.03