Beta-arrestin-2 - S1P2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
S1P2 75.2
Beta-arrestin-2 81.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 16.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 234 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 234 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 L 231 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 231 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 R 130 3x50 s5s6 L 74 N.s5s6.10
Polar ICL2 Y 140 34x53 S16 Y 250 C.S16.03
Hydrophobic ICL2 Y 140 34x53 S16 Y 250 C.S16.03
Van-der-waals ICL2 Y 140 34x53 S16 Y 250 C.S16.03
Hydrophobic TM2 M 68 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 M 68 2x39 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 K 136 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 134 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 I 134 3x54 S6 F 76 N.S6.01
Hydrophobic ICL2 V 137 34x50 s15s16 L 244 C.s15s16.02
Van-der-waals ICL2 V 137 34x50 s15s16 L 244 C.s15s16.02
Hydrophobic ICL2 L 139 34x52 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 I 134 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 134 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 Y 288 7x53 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 Y 288 7x53 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 Y 69 2x40 s5s6 D 68 N.s5s6.04
Polar ICL1 K 63 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 63 12x49 s20c D 402 C.s20c.12
Polar H8 S 292 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 292 8x47 s5s6 V 71 N.s5s6.07
Polar TM6 Q 227 6x29 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 Q 227 6x29 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 Q 227 6x29 s5s6 S 75 N.s5s6.11
Polar TM3 A 133 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 A 133 3x53 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 A 133 3x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 V 216 5x65 S6 F 76 N.S6.01
Hydrophobic ICL2 L 139 34x52 S5 Y 64 N.S5.12
Van-der-waals ICL2 L 139 34x52 S5 Y 64 N.S5.12
Hydrophobic ICL2 L 139 34x52 S8 L 130 N.S8.03
Van-der-waals ICL2 L 139 34x52 S8 L 130 N.S8.03
Hydrophobic ICL1 K 63 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 63 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM5 V 216 5x65 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 Y 140 34x53 s8s9 Q 131 N.s8s9.01
Van-der-waals ICL2 Y 140 34x53 s8s9 Q 131 N.s8s9.01
Polar ICL2 Y 140 34x53 S9 C 141 N.S9.01
Van-der-waals ICL2 Y 140 34x53 S9 C 141 N.S9.01
Hydrophobic ICL3 H 220 - S6 K 78 N.S6.03
Van-der-waals ICL3 H 220 - S6 K 78 N.S6.03
Van-der-waals ICL2 V 137 34x50 s5s6 R 66 N.s5s6.02
Polar TM5 S 219 5x68 S6 K 78 N.S6.03
Van-der-waals TM5 S 219 5x68 S6 K 78 N.S6.03
Hydrophobic TM3 A 133 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 133 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 I 212 5x61 s5s6 L 74 N.s5s6.10
Polar ICL2 L 139 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL2 L 139 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 L 139 34x52 S16 Y 250 C.S16.03
Polar TM6 Q 227 6x29 S6 R 77 N.S6.02
Hydrophobic TM6 Q 227 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 Q 227 6x29 S6 R 77 N.S6.02
Hydrophobic ICL2 L 139 34x52 S15 I 242 C.S15.14
Van-der-waals ICL2 L 139 34x52 S15 I 242 C.S15.14
Polar TM3 A 135 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 A 135 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 A 135 3x55 s15s16 S 246 C.s15s16.04
Polar ICL3 H 220 - S6 R 77 N.S6.02
Hydrophobic ICL3 H 220 - S6 R 77 N.S6.02
Van-der-waals ICL3 H 220 - S6 R 77 N.S6.02
Aromatic ICL3 H 220 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 H 220 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 H 220 - s15s16 F 245 C.s15s16.03
Hydrophobic TM2 M 68 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 M 68 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 V 137 34x50 S16 A 248 C.S16.01
Van-der-waals ICL2 V 137 34x50 S16 A 248 C.S16.01
Polar TM3 R 130 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 130 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 130 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 224 6x26 S6 K 78 N.S6.03
Polar TM3 A 133 3x53 S5 Y 64 N.S5.12
Van-der-waals TM3 A 133 3x53 S5 Y 64 N.S5.12
Ionic TM4 K 144 4x38 s8s9 D 136 N.s8s9.06
Hydrophobic TM5 V 215 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 M 223 - S6 L 80 N.S6.05
Van-der-waals ICL2 Y 140 34x53 s8s9 A 140 N.s8s9.10
Polar TM2 S 66 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 S 66 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 66 2x37 s5s6 D 68 N.s5s6.04
Polar ICL2 V 137 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 V 137 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 V 137 34x50 S5 Y 64 N.S5.12
Polar ICL1 K 63 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 K 63 12x49 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 K 63 12x49 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 S 219 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 S 219 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 V 137 34x50 s15s16 F 245 C.s15s16.03
Polar ICL2 V 137 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 V 137 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 V 137 34x50 s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 M 223 - S6 I 82 N.S6.07
Hydrophobic TM5 V 216 5x65 s5s6 L 74 N.s5s6.10
Polar ICL2 K 138 34x51 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 K 138 34x51 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 K 138 34x51 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 M 223 - S6 D 79 N.S6.04
Van-der-waals ICL3 M 223 - S6 D 79 N.S6.04
Polar TM3 I 134 3x54 S5 Y 64 N.S5.12
Polar TM3 K 136 3x56 s5s6 R 66 N.s5s6.02
Van-der-waals TM3 K 136 3x56 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 M 223 - S6 F 81 N.S6.06
Hydrophobic ICL2 Y 140 34x53 s17s18 G 287 C.s17s18.12
Polar TM6 L 231 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 L 231 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 L 231 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM2 M 68 2x39 s5s6 L 69 N.s5s6.05
Van-der-waals TM2 M 68 2x39 s5s6 L 69 N.s5s6.05
Polar ICL2 Y 140 34x53 S8 L 130 N.S8.03
Hydrophobic ICL2 Y 140 34x53 S8 L 130 N.S8.03
Van-der-waals ICL2 Y 140 34x53 S8 L 130 N.S8.03
Hydrophobic TM3 I 126 3x46 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 Y 140 34x53 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 Y 140 34x53 s8s9 D 136 N.s8s9.06
Hydrophobic TM2 L 72 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 L 72 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 V 137 34x50 S15 I 242 C.S15.14
Hydrophobic TM6 T 234 6x36 s5s6 G 73 N.s5s6.09
Hydrophobic ICL2 L 139 34x52 S9 C 141 N.S9.01
Van-der-waals ICL2 L 139 34x52 S9 C 141 N.S9.01
Hydrophobic TM2 Y 69 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 Y 69 2x40 s5s6 V 71 N.s5s6.07
Polar ICL2 Y 140 34x53 s8s9 P 132 N.s8s9.02
Hydrophobic ICL2 Y 140 34x53 s8s9 P 132 N.s8s9.02
Van-der-waals ICL2 Y 140 34x53 s8s9 P 132 N.s8s9.02