ArrestinDb

S-arrestin - S1P₂ receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
S1P₂	74.3
S-arrestin	81.0

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.6

iPTM Score: 0.4

PAE mean: 18.3

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	ICL2	Y	140	34x53	S16	Y	259	C.S16.03
Hydrophobic	TM2	S	66	2x37	s5s6	Q	73	N.s5s6.02
Hydrophobic	TM3	I	134	3x54	S6	F	83	N.S6.01
Hydrophobic	ICL2	L	139	34x52	S15	V	251	C.S15.14
Hydrophobic	TM3	A	133	3x53	S5	Y	71	N.S5.12
Hydrophobic	ICL3	M	223	-	S6	Y	88	N.S6.06
Hydrophobic	TM6	A	224	6x26	S6	R	85	N.S6.03
Hydrophobic	TM6	A	224	6x26	S6	D	86	N.S6.04
Hydrophobic	TM6	Q	227	6x29	S6	R	84	N.S6.02
Hydrophobic	ICL2	Y	140	34x53	s8s9	K	145	N.s8s9.09
Hydrophobic	ICL2	V	137	34x50	S5	Y	71	N.S5.12
Hydrophobic	TM3	R	130	3x50	s5s6	I	79	N.s5s6.08
Hydrophobic	TM2	M	68	2x39	s5s6	I	79	N.s5s6.08
Hydrophobic	TM3	A	135	3x55	s15s16	S	255	C.s15s16.04
Hydrophobic	H8	S	292	8x47	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL2	V	137	34x50	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	V	137	34x50	S16	D	257	C.S16.01
Hydrophobic	TM2	Y	69	2x40	s5s6	D	75	N.s5s6.04
Hydrophobic	ICL1	K	63	12x49	s20c	R	398	C.s20c.17
Hydrophobic	TM3	K	136	3x56	s15s16	S	255	C.s15s16.04
Hydrophobic	ICL2	L	139	34x52	s8s9	K	145	N.s8s9.09
Hydrophobic	ICL2	Y	140	34x53	s8s9	P	138	N.s8s9.02
Hydrophobic	ICL2	V	137	34x50	S15	V	251	C.S15.14
Hydrophobic	TM5	S	219	5x68	S6	R	85	N.S6.03
Hydrophobic	TM6	L	231	6x33	s5s6	I	79	N.s5s6.08
Hydrophobic	ICL3	H	220	-	S6	R	85	N.S6.03
Hydrophobic	TM2	Y	69	2x40	s5s6	V	78	N.s5s6.07
Hydrophobic	TM5	V	215	5x64	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	Y	140	34x53	s17s18	G	296	C.s17s18.12
Hydrophobic	TM2	L	72	2x43	s5s6	V	78	N.s5s6.07
Hydrophobic	TM5	S	219	5x68	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM6	Q	227	6x29	s5s6	T	82	N.s5s6.11
Hydrophobic	ICL2	L	139	34x52	s8s9	S	146	N.s8s9.10
Hydrophobic	ICL3	M	223	-	S6	D	86	N.S6.04
Hydrophobic	TM3	I	134	3x54	s5s6	L	81	N.s5s6.10
Hydrophobic	TM3	I	134	3x54	s15s16	Y	254	C.s15s16.03
Hydrophobic	TM5	V	216	5x65	S6	F	83	N.S6.01
Hydrophobic	TM2	M	68	2x39	s5s6	V	78	N.s5s6.07
Hydrophobic	ICL2	Y	140	34x53	s8s9	Q	137	N.s8s9.01
Hydrophobic	TM6	L	231	6x33	s5s6	L	81	N.s5s6.10
Hydrophobic	ICL3	H	220	-	S6	R	84	N.S6.02
Hydrophobic	TM6	T	234	6x36	s5s6	I	79	N.s5s6.08
Hydrophobic	TM2	S	66	2x37	s5s6	D	75	N.s5s6.04
Hydrophobic	ICL2	L	139	34x52	S5	Y	71	N.S5.12
Hydrophobic	ICL2	V	137	34x50	s15s16	S	255	C.s15s16.04
Hydrophobic	ICL3	M	223	-	S6	F	89	N.S6.07
Hydrophobic	ICL2	Y	140	34x53	S8	L	136	N.S8.03
Hydrophobic	ICL2	L	139	34x52	S16	Y	259	C.S16.03
Hydrophobic	ICL3	H	220	-	s15s16	Y	254	C.s15s16.03
Hydrophobic	ICL2	L	139	34x52	S9	C	147	N.S9.01
Hydrophobic	ICL2	K	138	34x51	S16	D	257	C.S16.01
Hydrophobic	ICL2	L	139	34x52	S8	L	136	N.S8.03
Ionic	H8	R	297	8x52	s20c	D	402	C.s20c.21
Ionic	ICL1	K	63	12x49	s20c	E	395	C.s20c.14
Polar	ICL2	Y	140	34x53	S16	Y	259	C.S16.03
Polar	ICL2	V	137	34x50	S16	Y	259	C.S16.03
Polar	TM3	K	136	3x56	S5	Y	71	N.S5.12
Polar	TM3	A	133	3x53	S5	Y	71	N.S5.12
Polar	TM6	Q	227	6x29	S6	R	84	N.S6.02
Polar	ICL2	Y	140	34x53	s8s9	K	145	N.s8s9.09
Polar	ICL2	V	137	34x50	S16	D	257	C.S16.01
Polar	H8	R	297	8x52	s20c	D	402	C.s20c.21
Polar	ICL2	Y	140	34x53	s8s9	P	138	N.s8s9.02
Polar	TM5	S	219	5x68	s15s16	L	253	C.s15s16.02
Polar	TM5	S	219	5x68	S6	R	85	N.S6.03
Polar	ICL2	Y	140	34x53	s8s9	S	146	N.s8s9.10
Polar	TM6	Q	227	6x29	s5s6	T	82	N.s5s6.11
Polar	ICL2	Y	140	34x53	s8s9	Q	137	N.s8s9.01
Polar	TM6	T	234	6x36	s5s6	I	79	N.s5s6.08
Polar	TM2	S	66	2x37	s5s6	D	75	N.s5s6.04
Polar	ICL2	Y	140	34x53	S9	C	147	N.S9.01
Polar	ICL2	K	138	34x51	S5	Y	71	N.S5.12
Polar	ICL2	V	137	34x50	s15s16	S	255	C.s15s16.04
Polar	ICL2	Y	140	34x53	S8	L	136	N.S8.03
Polar	ICL2	L	139	34x52	S16	Y	259	C.S16.03
Polar	ICL3	H	220	-	s15s16	Y	254	C.s15s16.03
Polar	ICL2	K	138	34x51	S16	D	257	C.S16.01
Van-der-waals	TM3	I	134	3x54	S6	F	83	N.S6.01
Van-der-waals	ICL2	V	137	34x50	S16	Y	259	C.S16.03
Van-der-waals	TM3	A	133	3x53	S5	Y	71	N.S5.12
Van-der-waals	TM6	Q	227	6x29	S6	R	84	N.S6.02
Van-der-waals	ICL2	Y	140	34x53	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL2	V	137	34x50	S5	Y	71	N.S5.12
Van-der-waals	TM3	R	130	3x50	s5s6	I	79	N.s5s6.08
Van-der-waals	TM3	A	135	3x55	s15s16	S	255	C.s15s16.04
Van-der-waals	ICL2	V	137	34x50	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	V	137	34x50	S16	D	257	C.S16.01
Van-der-waals	TM2	Y	69	2x40	s5s6	D	75	N.s5s6.04
Van-der-waals	ICL1	K	63	12x49	s20c	R	398	C.s20c.17
Van-der-waals	ICL2	L	139	34x52	s8s9	K	145	N.s8s9.09
Van-der-waals	ICL2	Y	140	34x53	s8s9	P	138	N.s8s9.02
Van-der-waals	ICL2	V	137	34x50	S15	V	251	C.S15.14
Van-der-waals	TM5	S	219	5x68	S6	R	85	N.S6.03
Van-der-waals	ICL3	H	220	-	S6	R	85	N.S6.03
Van-der-waals	TM2	Y	69	2x40	s5s6	V	78	N.s5s6.07
Van-der-waals	ICL2	Y	140	34x53	s17s18	G	296	C.s17s18.12
Van-der-waals	TM2	L	72	2x43	s5s6	V	78	N.s5s6.07
Van-der-waals	TM5	S	219	5x68	s15s16	Y	254	C.s15s16.03
Van-der-waals	TM6	Q	227	6x29	s5s6	T	82	N.s5s6.11
Van-der-waals	ICL3	M	223	-	S6	D	86	N.S6.04
Van-der-waals	TM3	I	134	3x54	s15s16	Y	254	C.s15s16.03
Van-der-waals	TM5	V	216	5x65	S6	F	83	N.S6.01
Van-der-waals	ICL2	Y	140	34x53	s8s9	Q	137	N.s8s9.01
Van-der-waals	TM6	L	231	6x33	s5s6	L	81	N.s5s6.10
Van-der-waals	TM6	T	234	6x36	s5s6	I	79	N.s5s6.08
Van-der-waals	TM2	S	66	2x37	s5s6	D	75	N.s5s6.04
Van-der-waals	ICL2	L	139	34x52	S5	Y	71	N.S5.12
Van-der-waals	ICL2	V	137	34x50	s15s16	S	255	C.s15s16.04
Van-der-waals	ICL3	M	223	-	S6	F	89	N.S6.07
Van-der-waals	ICL2	Y	140	34x53	S8	L	136	N.S8.03
Van-der-waals	ICL2	L	139	34x52	S16	Y	259	C.S16.03
Van-der-waals	ICL3	H	220	-	s15s16	Y	254	C.s15s16.03
Van-der-waals	ICL2	L	139	34x52	S9	C	147	N.S9.01
Van-der-waals	ICL2	K	138	34x51	S16	D	257	C.S16.01
Van-der-waals	ICL2	K	138	34x51	S16	Y	259	C.S16.03
Van-der-waals	ICL2	L	139	34x52	S8	L	136	N.S8.03

Showing 1 to 116 of 116 entries

Join us

Cite us

Main reference

S-arrestin - S1P2 receptor complex model Download Full