Beta-arrestin-2 - S1P3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
S1P3 74.6
Beta-arrestin-2 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 S 225 5x68 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 S 225 5x68 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 S 225 5x68 s15s16 L 244 C.s15s16.02
Hydrophobic TM2 Y 75 2x40 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 R 237 6x29 S6 R 77 N.S6.02
Van-der-waals TM6 R 237 6x29 S6 R 77 N.S6.02
Polar ICL2 M 143 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 143 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 M 143 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 143 34x50 S15 I 242 C.S15.14
Hydrophobic TM3 T 139 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 T 139 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 S 226 5x69 S6 K 78 N.S6.03
Van-der-waals TM5 S 226 5x69 S6 K 78 N.S6.03
Polar C-term C 363 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term C 363 - s17s18 R 286 C.s17s18.11
Van-der-waals C-term C 363 - s17s18 R 286 C.s17s18.11
Hydrophobic C-term P 360 - s17s18 E 284 C.s17s18.09
Hydrophobic TM5 L 221 5x64 s15s16 F 245 C.s15s16.03
Polar ICL2 M 143 34x50 S16 Y 250 C.S16.03
Van-der-waals ICL2 M 143 34x50 S16 Y 250 C.S16.03
Hydrophobic TM6 L 241 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 L 241 6x33 s5s6 G 73 N.s5s6.09
Hydrophobic TM5 S 225 5x68 S6 F 76 N.S6.01
Hydrophobic TM3 K 142 3x56 S16 A 248 C.S16.01
Van-der-waals TM3 K 142 3x56 S16 A 248 C.S16.01
Hydrophobic TM5 I 218 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 A 301 7x56 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 A 301 7x56 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 A 148 34x55 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 A 148 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 Y 75 2x40 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 Y 75 2x40 s5s6 V 71 N.s5s6.07
Polar TM2 N 72 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 N 72 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 N 72 2x37 s5s6 D 68 N.s5s6.04
Polar C-term C 363 - S16 C 252 C.S16.05
Hydrophobic C-term C 363 - S16 C 252 C.S16.05
Van-der-waals C-term C 363 - S16 C 252 C.S16.05
Polar TM3 T 139 3x53 S5 Y 64 N.S5.12
Hydrophobic TM5 V 222 5x65 S6 F 76 N.S6.01
Polar ICL1 K 69 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL1 K 69 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 69 12x49 s20c Y 404 C.s20c.14
Hydrophobic ICL3 V 229 - s17s18 V 315 C.s17s18.40
Hydrophobic TM5 V 222 5x65 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 I 78 2x43 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 78 2x43 s5s6 V 71 N.s5s6.07
Polar TM5 K 228 5x71 s17s18 N 312 C.s17s18.37
Hydrophobic C-term M 365 - S16 A 248 C.S16.01
Polar TM3 K 142 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 K 142 3x56 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 P 145 34x52 s17s18 G 287 C.s17s18.12
Hydrophobic C-term C 363 - s17s18 K 285 C.s17s18.10
Hydrophobic TM6 N 234 6x26 S6 I 82 N.S6.07
Van-der-waals TM6 N 234 6x26 S6 I 82 N.S6.07
Hydrophobic ICL3 V 229 - s17s18 E 314 C.s17s18.39
Hydrophobic H8 S 302 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL3 V 229 - S6 L 80 N.S6.05
Van-der-waals ICL3 V 229 - S6 L 80 N.S6.05
Hydrophobic ICL2 Y 146 34x53 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 Y 146 34x53 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 S 225 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 S 225 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 M 140 3x54 S5 Y 64 N.S5.12
Hydrophobic ICL2 M 143 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 M 143 34x50 s15s16 S 246 C.s15s16.04
Polar ICL2 R 144 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 R 144 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 R 144 34x51 S16 Y 250 C.S16.03
Hydrophobic TM7 Y 298 7x53 s5s6 L 72 N.s5s6.08
Hydrophobic C-term C 363 - S16 K 251 C.S16.04
Van-der-waals C-term C 363 - S16 K 251 C.S16.04
Hydrophobic TM3 I 132 3x46 s5s6 L 72 N.s5s6.08
Ionic TM5 K 228 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 228 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 K 228 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 228 5x71 s17s18 E 314 C.s17s18.39
Polar TM3 I 141 3x55 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 I 141 3x55 s15s16 S 246 C.s15s16.04
Van-der-waals TM3 I 141 3x55 s15s16 S 246 C.s15s16.04
Polar C-term I 364 - S16 K 251 C.S16.04
Van-der-waals C-term I 364 - S16 K 251 C.S16.04
Polar TM3 R 136 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 136 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 136 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 M 143 34x50 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 M 143 34x50 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 A 148 34x55 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 A 148 34x55 s17s18 R 286 C.s17s18.11
Polar ICL2 Y 146 34x53 s17s18 R 286 C.s17s18.11
Van-der-waals ICL2 Y 146 34x53 s17s18 R 286 C.s17s18.11
Hydrophobic ICL3 A 230 - S6 D 79 N.S6.04
Van-der-waals ICL3 A 230 - S6 D 79 N.S6.04
Hydrophobic ICL3 V 229 - s15s16 L 244 C.s15s16.02
Hydrophobic ICL3 V 229 - S6 K 78 N.S6.03
Van-der-waals ICL3 V 229 - S6 K 78 N.S6.03
Hydrophobic C-term M 365 - S16 Y 250 C.S16.03
Van-der-waals C-term M 365 - S16 Y 250 C.S16.03
Hydrophobic TM6 L 241 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 L 241 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 T 244 6x36 s5s6 G 73 N.s5s6.09
Polar TM6 N 234 6x26 S6 D 79 N.S6.04
Hydrophobic TM6 N 234 6x26 S6 D 79 N.S6.04
Van-der-waals TM6 N 234 6x26 S6 D 79 N.S6.04
Polar TM5 S 225 5x68 S6 K 78 N.S6.03
Hydrophobic TM5 S 225 5x68 S6 K 78 N.S6.03
Van-der-waals TM5 S 225 5x68 S6 K 78 N.S6.03
Hydrophobic TM6 T 244 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM3 R 136 3x50 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 R 136 3x50 s5s6 L 74 N.s5s6.10
Ionic TM4 R 151 4x39 s8s9 E 135 N.s8s9.05
Polar TM4 R 151 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 R 151 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 R 151 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 M 74 2x39 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 M 74 2x39 s5s6 L 72 N.s5s6.08
Ionic C-term D 366 - S16 K 251 C.S16.04
Polar C-term D 366 - S16 K 251 C.S16.04
Hydrophobic C-term D 366 - S16 K 251 C.S16.04
Van-der-waals C-term D 366 - S16 K 251 C.S16.04
Polar ICL2 R 144 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 R 144 34x51 S5 Y 64 N.S5.12
Polar ICL2 P 145 34x52 S16 Y 250 C.S16.03
Hydrophobic ICL2 P 145 34x52 S16 Y 250 C.S16.03
Van-der-waals ICL2 P 145 34x52 S16 Y 250 C.S16.03
Hydrophobic TM2 I 78 2x43 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 M 74 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 M 140 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 M 140 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic H8 R 307 8x52 s20c L 408 C.s20c.18
Van-der-waals H8 R 307 8x52 s20c L 408 C.s20c.18
Hydrophobic H8 E 304 8x49 s5s6 E 67 N.s5s6.03