Beta-arrestin-1 - S1P4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
S1P4 71.8
Beta-arrestin-1 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 150 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 150 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 V 230 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 V 230 5x65 S6 F 75 N.S6.01
Polar TM6 R 239 6x23 S5 T 56 N.S5.05
Van-der-waals TM6 R 239 6x23 S5 T 56 N.S5.05
Hydrophobic TM2 W 80 2x38 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 R 143 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 143 3x50 s5s6 L 71 N.s5s6.08
Polar TM3 T 146 3x53 S5 Y 63 N.S5.12
Hydrophobic TM3 T 146 3x53 S5 Y 63 N.S5.12
Van-der-waals TM3 T 146 3x53 S5 Y 63 N.S5.12
Hydrophobic ICL3 K 236 - S6 K 77 N.S6.03
Polar TM6 K 245 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 K 245 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic TM6 L 249 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 249 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM4 K 158 4x38 s5s6 R 65 N.s5s6.02
Van-der-waals TM4 K 158 4x38 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 L 249 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 249 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 P 150 34x50 s15s16 L 243 C.s15s16.02
Van-der-waals ICL2 P 150 34x50 s15s16 L 243 C.s15s16.02
Polar TM3 V 148 3x55 S5 Y 63 N.S5.12
Polar TM3 R 149 3x56 S5 Y 63 N.S5.12
Hydrophobic TM3 R 149 3x56 S5 Y 63 N.S5.12
Van-der-waals TM3 R 149 3x56 S5 Y 63 N.S5.12
Hydrophobic TM3 T 146 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 T 146 3x53 s5s6 R 65 N.s5s6.02
Polar TM6 R 239 6x23 S5 T 58 N.S5.07
Hydrophobic TM6 R 239 6x23 S5 T 58 N.S5.07
Van-der-waals TM6 R 239 6x23 S5 T 58 N.S5.07
Hydrophobic TM2 L 85 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 85 2x43 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 V 81 2x39 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 V 81 2x39 s5s6 L 68 N.s5s6.05
Ionic TM2 R 79 2x37 s5s6 D 67 N.s5s6.04
Polar TM2 R 79 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 R 79 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 R 79 2x37 s5s6 D 67 N.s5s6.04
Polar H8 S 311 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 S 311 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 V 151 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 V 151 34x51 S16 Y 249 C.S16.03
Hydrophobic TM6 I 256 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 I 256 6x40 s5s6 L 71 N.s5s6.08
Polar ICL2 V 151 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 V 151 34x51 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 V 151 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 150 34x50 S15 I 241 C.S15.14
Van-der-waals ICL2 P 150 34x50 S15 I 241 C.S15.14
Hydrophobic TM3 M 147 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 M 147 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 V 81 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 V 81 2x39 s5s6 D 67 N.s5s6.04
Ionic H8 R 312 8x48 s20c E 407 C.s20c.17
Polar H8 R 312 8x48 s20c E 407 C.s20c.17
Hydrophobic TM5 V 230 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 P 150 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 V 151 34x51 S15 I 241 C.S15.14
Polar TM3 V 148 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 V 148 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 V 148 3x55 s15s16 N 245 C.s15s16.04
Ionic TM6 R 239 6x23 S6 D 78 N.S6.04
Polar TM6 R 239 6x23 S6 D 78 N.S6.04
Hydrophobic TM6 R 239 6x23 S6 D 78 N.S6.04
Van-der-waals TM6 R 239 6x23 S6 D 78 N.S6.04
Hydrophobic TM5 S 233 5x68 S6 K 77 N.S6.03
Hydrophobic ICL2 A 152 34x52 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 A 152 34x52 s5s6 R 65 N.s5s6.02
Polar TM6 T 252 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 T 252 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 252 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic ICL3 A 237 - S6 V 81 N.S6.07
Van-der-waals TM6 R 239 6x23 S6 R 76 N.S6.02
Hydrophobic ICL2 V 151 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 V 151 34x51 s15s16 N 245 C.s15s16.04
Ionic H8 R 316 8x52 s20c E 405 C.s20c.15
Polar H8 R 316 8x52 s20c E 405 C.s20c.15
Polar ICL1 S 77 12x50 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 S 77 12x50 s8s9 T 136 N.s8s9.07
Hydrophobic ICL3 A 237 - S6 D 78 N.S6.04
Van-der-waals ICL3 A 237 - S6 D 78 N.S6.04
Hydrophobic TM6 V 253 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 R 239 6x23 S6 V 81 N.S6.07
Van-der-waals TM6 R 239 6x23 S6 V 81 N.S6.07
Hydrophobic TM3 T 146 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 T 146 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 V 151 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 V 151 34x51 S16 A 247 C.S16.01
Polar TM2 R 79 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM2 R 79 2x37 s8s9 T 136 N.s8s9.07
Van-der-waals TM2 R 79 2x37 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 L 229 5x64 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 L 229 5x64 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 M 147 3x54 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 M 147 3x54 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 Y 223 5x58 s5s6 L 71 N.s5s6.08
Van-der-waals TM5 Y 223 5x58 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 V 148 3x55 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 V 148 3x55 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 S 233 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 S 233 5x68 s15s16 F 244 C.s15s16.03
Polar TM3 M 147 3x54 S5 Y 63 N.S5.12
Hydrophobic TM3 M 147 3x54 S5 Y 63 N.S5.12
Van-der-waals TM3 M 147 3x54 S5 Y 63 N.S5.12
Hydrophobic TM3 R 143 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 R 143 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 P 240 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic TM3 M 147 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 M 147 3x54 S6 F 75 N.S6.01
Polar ICL2 E 153 34x53 s5s6 R 65 N.s5s6.02
Polar ICL2 E 153 34x53 S16 Y 249 C.S16.03
Polar ICL2 P 150 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 P 150 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 150 34x50 S5 Y 63 N.S5.12
Polar C-term S 349 - s9s10 K 157 N.s9s10.09
Van-der-waals C-term S 349 - s9s10 K 157 N.s9s10.09
Hydrophobic TM6 K 245 6x29 s5s6 L 73 N.s5s6.10
Ionic TM3 R 143 3x50 s5s6 D 69 N.s5s6.06
Hydrophobic ICL2 P 150 34x50 S16 A 247 C.S16.01
Polar TM3 R 149 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 R 149 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 R 149 3x56 s15s16 N 245 C.s15s16.04
Polar ICL2 A 152 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 A 152 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 A 152 34x52 S16 Y 249 C.S16.03
Hydrophobic TM7 R 310 7x56 s5s6 L 71 N.s5s6.08
Ionic TM6 R 239 6x23 S9 E 145 N.S9.06
Polar TM6 R 244 6x28 s9s10 E 155 N.s9s10.07
Hydrophobic TM2 V 81 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 V 81 2x39 s5s6 V 70 N.s5s6.07