S-arrestin - S1P4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
S1P4 70.2
S-arrestin 79.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM2 L 85 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 85 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 P 240 6x24 s9s10 E 165 N.s9s10.07
Hydrophobic TM3 M 147 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 M 147 3x54 S6 F 83 N.S6.01
Hydrophobic ICL3 A 237 - S6 D 86 N.S6.04
Van-der-waals ICL3 A 237 - S6 D 86 N.S6.04
Hydrophobic ICL2 V 151 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 V 151 34x51 S16 D 257 C.S16.01
Van-der-waals H8 R 312 8x48 s5s6 D 75 N.s5s6.04
Polar H8 S 311 8x47 s5s6 D 75 N.s5s6.04
Van-der-waals H8 S 311 8x47 s5s6 D 75 N.s5s6.04
Hydrophobic TM6 I 256 6x40 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 256 6x40 s5s6 I 79 N.s5s6.08
Polar TM6 A 242 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 A 242 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 A 242 6x26 S6 D 86 N.S6.04
Polar ICL1 R 78 12x51 s8s9 Q 141 N.s8s9.05
Hydrophobic TM7 R 310 7x56 s5s6 G 80 N.s5s6.09
Van-der-waals TM7 R 310 7x56 s5s6 G 80 N.s5s6.09
Polar TM6 R 239 6x23 S5 T 66 N.S5.07
Hydrophobic TM6 R 239 6x23 S5 T 66 N.S5.07
Van-der-waals TM6 R 239 6x23 S5 T 66 N.S5.07
Ionic TM6 R 244 6x28 s9s10 D 166 N.s9s10.08
Polar TM6 R 244 6x28 s9s10 D 166 N.s9s10.08
Hydrophobic TM6 R 244 6x28 s9s10 D 166 N.s9s10.08
Van-der-waals TM6 R 244 6x28 s9s10 D 166 N.s9s10.08
Polar TM2 R 79 2x37 s8s9 S 143 N.s8s9.07
Hydrophobic TM2 R 79 2x37 s8s9 S 143 N.s8s9.07
Van-der-waals TM2 R 79 2x37 s8s9 S 143 N.s8s9.07
Hydrophobic TM3 R 143 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 143 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 150 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 150 34x50 s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 R 310 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 R 310 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 R 244 6x28 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 244 6x28 s9s10 E 165 N.s9s10.07
Polar TM5 S 233 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 S 233 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 S 233 5x68 S6 R 85 N.S6.03
Hydrophobic TM6 P 240 6x24 S6 F 89 N.S6.07
Polar TM2 Y 82 2x40 s5s6 Q 73 N.s5s6.02
Hydrophobic TM7 R 310 7x56 s5s6 D 77 N.s5s6.06
Van-der-waals TM7 R 310 7x56 s5s6 D 77 N.s5s6.06
Ionic TM6 R 244 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 244 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 244 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 244 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM7 Y 307 7x53 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 Y 307 7x53 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 L 249 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 L 249 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic H8 S 311 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 S 311 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 Y 307 7x53 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 Y 307 7x53 s5s6 I 79 N.s5s6.08
Ionic TM6 R 247 6x31 s9s10 E 164 N.s9s10.06
Polar TM6 R 247 6x31 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 247 6x31 s9s10 E 164 N.s9s10.06
Polar TM6 T 252 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 T 252 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 T 252 6x36 s5s6 I 79 N.s5s6.08
Polar H8 S 311 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 S 311 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 311 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 L 249 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 R 310 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 M 147 3x54 s5s6 L 81 N.s5s6.10
Polar H8 E 313 8x49 s5s6 Q 73 N.s5s6.02
Hydrophobic H8 E 313 8x49 s5s6 Q 73 N.s5s6.02
Van-der-waals H8 E 313 8x49 s5s6 Q 73 N.s5s6.02
Polar H8 E 313 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 E 313 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 E 313 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic TM6 R 239 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 R 239 6x23 S6 D 86 N.S6.04
Polar ICL2 A 152 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 A 152 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 A 152 34x52 S16 D 257 C.S16.01
Hydrophobic TM3 R 143 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 143 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 R 79 2x37 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 R 79 2x37 s5s6 I 76 N.s5s6.05
Hydrophobic H8 V 314 8x50 s5s6 V 78 N.s5s6.07
Polar TM6 K 245 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 K 245 6x29 s5s6 T 82 N.s5s6.11
Van-der-waals TM6 K 245 6x29 s5s6 T 82 N.s5s6.11
Hydrophobic TM6 R 239 6x23 S6 F 89 N.S6.07
Van-der-waals TM6 R 239 6x23 S6 F 89 N.S6.07
Polar ICL2 P 150 34x50 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 P 150 34x50 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 P 150 34x50 s15s16 S 256 C.s15s16.05
Polar TM6 R 239 6x23 S5 T 64 N.S5.05
Hydrophobic TM6 R 239 6x23 S5 T 64 N.S5.05
Van-der-waals TM6 R 239 6x23 S5 T 64 N.S5.05
Hydrophobic TM6 A 241 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 A 241 6x25 s9s10 E 165 N.s9s10.07
Polar ICL2 A 152 34x52 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 A 152 34x52 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 A 152 34x52 s15s16 S 256 C.s15s16.05
Hydrophobic ICL3 P 238 - S6 F 89 N.S6.07
Van-der-waals ICL3 P 238 - S6 F 89 N.S6.07
Hydrophobic TM3 T 146 3x53 S5 Y 71 N.S5.12
Polar TM6 R 239 6x23 S5 L 65 N.S5.06
Hydrophobic TM6 R 239 6x23 S5 L 65 N.S5.06
Van-der-waals TM6 R 239 6x23 S5 L 65 N.S5.06
Hydrophobic ICL2 P 150 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 150 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 A 152 34x52 S16 Y 258 C.S16.02
Van-der-waals ICL2 A 152 34x52 S16 Y 258 C.S16.02
Hydrophobic TM6 A 241 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 A 241 6x25 S6 D 86 N.S6.04
Hydrophobic TM3 M 147 3x54 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 Y 223 5x58 s5s6 I 79 N.s5s6.08
Van-der-waals TM5 Y 223 5x58 s5s6 I 79 N.s5s6.08
Polar TM2 R 79 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM2 R 79 2x37 s5s6 Q 73 N.s5s6.02
Van-der-waals TM2 R 79 2x37 s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 P 240 6x24 s9s10 A 163 N.s9s10.05
Van-der-waals TM6 P 240 6x24 s9s10 A 163 N.s9s10.05
Ionic TM6 R 239 6x23 s9s10 E 165 N.s9s10.07
Polar TM6 R 239 6x23 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 R 239 6x23 s9s10 E 165 N.s9s10.07
Ionic TM6 R 248 6x32 s5s6 D 77 N.s5s6.06
Polar TM6 R 248 6x32 s5s6 D 77 N.s5s6.06
Van-der-waals TM6 R 248 6x32 s5s6 D 77 N.s5s6.06
Polar ICL1 S 77 12x50 s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 S 77 12x50 s8s9 Q 141 N.s8s9.05
Polar ICL2 E 153 34x53 S16 D 257 C.S16.01
Van-der-waals TM3 T 146 3x53 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 K 245 6x29 S6 R 84 N.S6.02
Van-der-waals TM6 K 245 6x29 S6 R 84 N.S6.02
Hydrophobic TM2 V 81 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 V 81 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 R 79 2x37 s8s9 G 144 N.s8s9.08
Van-der-waals TM2 R 79 2x37 s8s9 G 144 N.s8s9.08
Hydrophobic TM5 V 230 5x65 S6 F 83 N.S6.01
Hydrophobic TM2 V 81 2x39 s5s6 I 76 N.s5s6.05
Van-der-waals TM2 V 81 2x39 s5s6 I 76 N.s5s6.05
Hydrophobic ICL2 V 151 34x51 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 V 151 34x51 s15s16 S 256 C.s15s16.05