Beta-arrestin-1 - S1P5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
S1P5 67.1
Beta-arrestin-1 78.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 22.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM3 R 133 3x50 s5s6 L 68 N.s5s6.05
Hydrophobic TM3 R 133 3x50 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 R 133 3x50 s5s6 L 68 N.s5s6.05
Polar TM3 T 136 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 T 136 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 T 136 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 T 136 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 T 136 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM5 L 226 5x72 S6 D 78 N.S6.04
Van-der-waals TM5 L 226 5x72 S6 D 78 N.S6.04
Polar TM6 R 242 6x26 S6 N 83 N.S6.09
Hydrophobic TM5 V 219 5x65 S6 F 75 N.S6.01
Hydrophobic TM6 R 245 6x29 s5s6 T 74 N.s5s6.11
Van-der-waals TM6 R 245 6x29 s5s6 T 74 N.s5s6.11
Hydrophobic ICL2 A 143 34x53 s5s6 R 65 N.s5s6.02
Polar TM3 R 133 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 R 133 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 133 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 L 249 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 249 6x33 s5s6 L 73 N.s5s6.10
Polar TM6 L 249 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 L 249 6x33 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 L 249 6x33 s5s6 G 72 N.s5s6.09
Hydrophobic TM2 F 72 2x40 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 F 72 2x40 s5s6 D 67 N.s5s6.04
Hydrophobic TM2 L 75 2x43 s5s6 V 70 N.s5s6.07
Polar H8 N 310 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 310 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 310 8x47 s5s6 D 69 N.s5s6.06
Ionic TM5 R 225 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 R 225 5x71 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 R 225 5x71 s17s18 E 313 C.s17s18.39
Ionic H8 R 319 8x56 s20c E 407 C.s20c.17
Polar H8 R 319 8x56 s20c E 407 C.s20c.17
Hydrophobic H8 R 319 8x56 s20c E 407 C.s20c.17
Van-der-waals H8 R 319 8x56 s20c E 407 C.s20c.17
Hydrophobic TM3 M 137 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 M 137 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 V 256 6x40 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 256 6x40 s5s6 L 71 N.s5s6.08
Polar TM3 R 139 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 R 139 3x56 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 R 139 3x56 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 226 5x72 s17s18 I 314 C.s17s18.40
Hydrophobic H8 N 310 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 310 8x47 s5s6 V 70 N.s5s6.07
Polar ICL2 R 140 34x50 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 R 140 34x50 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 R 140 34x50 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 V 219 5x65 s15s16 F 244 C.s15s16.03
Polar TM3 T 136 3x53 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 T 136 3x53 s15s16 N 245 C.s15s16.04
Polar ICL2 A 143 34x53 S16 Y 249 C.S16.03
Hydrophobic TM2 M 71 2x39 s5s6 L 68 N.s5s6.05
Van-der-waals TM2 M 71 2x39 s5s6 L 68 N.s5s6.05
Ionic ICL1 R 66 12x49 s20c D 402 C.s20c.12
Polar ICL1 R 66 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 R 66 12x49 s20c D 402 C.s20c.12
Hydrophobic TM2 M 71 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 M 71 2x39 s5s6 V 70 N.s5s6.07
Polar TM6 T 252 6x36 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 T 252 6x36 s5s6 G 72 N.s5s6.09
Hydrophobic TM5 L 226 5x72 S6 L 79 N.S6.05
Hydrophobic TM6 T 252 6x36 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 T 252 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 F 72 2x40 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 F 72 2x40 s5s6 V 70 N.s5s6.07
Polar ICL2 G 141 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 G 141 34x51 s15s16 T 246 C.s15s16.05
Polar TM5 N 222 5x68 S6 K 77 N.S6.03
Hydrophobic TM5 N 222 5x68 S6 K 77 N.S6.03
Van-der-waals TM5 N 222 5x68 S6 K 77 N.S6.03
Hydrophobic TM5 L 226 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 L 226 5x72 S6 K 77 N.S6.03
Ionic TM3 E 132 3x49 s5s6 R 65 N.s5s6.02
Polar TM3 E 132 3x49 s5s6 R 65 N.s5s6.02
Hydrophobic ICL2 P 142 34x52 S16 A 247 C.S16.01
Hydrophobic TM6 L 253 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 253 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 N 222 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 N 222 5x68 s15s16 F 244 C.s15s16.03
Polar TM6 R 241 6x25 s9s10 E 155 N.s9s10.07
Hydrophobic TM3 I 129 3x46 s5s6 L 71 N.s5s6.08
Ionic ICL1 R 66 12x49 s20c E 404 C.s20c.14
Polar ICL1 R 66 12x49 s20c E 404 C.s20c.14
Hydrophobic ICL1 R 66 12x49 s20c E 404 C.s20c.14
Van-der-waals ICL1 R 66 12x49 s20c E 404 C.s20c.14
Polar ICL1 R 66 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 R 66 12x49 s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 R 66 12x49 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 140 34x50 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 140 34x50 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 P 227 5x73 s17s18 I 314 C.s17s18.40
Van-der-waals TM5 P 227 5x73 s17s18 I 314 C.s17s18.40
Hydrophobic TM6 R 245 6x29 S6 R 76 N.S6.02
Van-der-waals TM6 R 245 6x29 S6 R 76 N.S6.02
Polar ICL2 P 142 34x52 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 P 142 34x52 s15s16 N 245 C.s15s16.04
Hydrophobic TM2 M 71 2x39 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 M 71 2x39 s5s6 D 67 N.s5s6.04
Polar ICL1 P 65 12x48 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 P 65 12x48 s8s9 T 136 N.s8s9.07
Hydrophobic TM3 R 133 3x50 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 R 133 3x50 s5s6 L 73 N.s5s6.10
Ionic ICL2 R 140 34x50 s17s18 E 313 C.s17s18.39
Polar ICL2 R 140 34x50 s17s18 E 313 C.s17s18.39
Van-der-waals ICL2 R 140 34x50 s17s18 E 313 C.s17s18.39
Hydrophobic ICL2 R 140 34x50 S16 A 247 C.S16.01
Hydrophobic TM6 A 240 6x24 s9s10 E 155 N.s9s10.07
Van-der-waals TM6 A 240 6x24 s9s10 E 155 N.s9s10.07
Hydrophobic H8 R 311 8x48 s9s10 K 160 N.s9s10.12
Hydrophobic TM2 A 69 2x37 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 P 142 34x52 S8 L 129 N.S8.03
Hydrophobic TM7 Y 306 7x53 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 R 229 5x75 s7s8 P 120 N.s7s8.03
Hydrophobic ICL2 G 141 34x51 S16 A 247 C.S16.01
Van-der-waals ICL2 G 141 34x51 S16 A 247 C.S16.01
Hydrophobic TM7 Y 306 7x53 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 P 142 34x52 S15 I 241 C.S15.14
Van-der-waals ICL2 P 142 34x52 S15 I 241 C.S15.14
Hydrophobic TM2 M 71 2x39 s5s6 L 71 N.s5s6.08
Van-der-waals TM2 M 71 2x39 s5s6 L 71 N.s5s6.08
Polar ICL2 P 142 34x52 S16 Y 249 C.S16.03
Hydrophobic ICL2 P 142 34x52 S16 Y 249 C.S16.03
Van-der-waals ICL2 P 142 34x52 S16 Y 249 C.S16.03
Ionic TM4 R 148 4x39 s8s9 E 134 N.s8s9.05
Polar TM4 R 148 4x39 s8s9 E 134 N.s8s9.05
Polar ICL2 G 141 34x51 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 G 141 34x51 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 G 141 34x51 s15s16 N 245 C.s15s16.04
Polar ICL2 R 140 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 R 140 34x50 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 R 140 34x50 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 M 137 3x54 S6 F 75 N.S6.01
Van-der-waals TM3 M 137 3x54 S6 F 75 N.S6.01
Polar TM6 R 242 6x26 s9s10 L 154 N.s9s10.03
Polar TM7 T 309 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 T 309 7x56 s5s6 V 70 N.s5s6.07