Arrestin-C - SMO complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
SMO 65.2
Arrestin-C 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar C-term E 779 - s9s10 K 157 N.s9s10.12
Hydrophobic C-term E 779 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term E 779 - s9s10 K 157 N.s9s10.12
Polar ICL2 T 349 - s15s16 L 243 C.s15s16.05
Hydrophobic ICL2 T 349 - s15s16 L 243 C.s15s16.05
Van-der-waals ICL2 T 349 - s15s16 L 243 C.s15s16.05
Polar C-term L 775 - S6 R 72 N.S6.02
Hydrophobic C-term L 775 - S6 R 72 N.S6.02
Van-der-waals C-term L 775 - S6 R 72 N.S6.02
Hydrophobic TM3 W 339 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 W 339 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM1 F 252 1x54 s5s6 V 66 N.s5s6.07
Ionic C-term D 784 - s17s18 K 291 C.s17s18.20
Polar C-term D 784 - s17s18 K 291 C.s17s18.20
Hydrophobic C-term D 784 - s17s18 K 291 C.s17s18.20
Van-der-waals C-term D 784 - s17s18 K 291 C.s17s18.20
Hydrophobic ICL2 T 349 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 T 349 - s15s16 Y 241 C.s15s16.03
Ionic C-term D 786 - s17s18 H 292 C.s17s18.21
Hydrophobic TM6 I 445 6x26 s5s6 L 69 N.s5s6.10
Hydrophobic C-term S 771 - s17s18 L 311 C.s17s18.40
Hydrophobic C-term S 771 - S6 K 73 N.S6.03
Polar C-term N 774 - S6 R 72 N.S6.02
Hydrophobic C-term N 774 - S6 R 72 N.S6.02
Van-der-waals C-term N 774 - S6 R 72 N.S6.02
Ionic C-term R 772 - s9s10 E 152 N.s9s10.07
Polar C-term R 772 - s9s10 E 152 N.s9s10.07
Van-der-waals C-term R 772 - s9s10 E 152 N.s9s10.07
Hydrophobic H8 I 544 8x53 s5s6 L 64 N.s5s6.05
Hydrophobic C-term L 766 - s7s8 V 117 N.s7s8.03
Hydrophobic C-term R 772 - S6 V 77 N.S6.07
Hydrophobic C-term M 776 - S5 R 58 N.S5.11
Van-der-waals C-term M 776 - S5 R 58 N.S5.11
Polar C-term R 772 - S6 D 74 N.S6.04
Hydrophobic C-term R 772 - S6 D 74 N.S6.04
Van-der-waals C-term R 772 - S6 D 74 N.S6.04
Ionic C-term D 786 - s17s18 K 291 C.s17s18.20
Hydrophobic C-term D 786 - s17s18 K 291 C.s17s18.20
Van-der-waals C-term D 786 - s17s18 K 291 C.s17s18.20
Hydrophobic C-term L 775 - s5s6 L 69 N.s5s6.10
Polar C-term R 562 - s8s9 Q 127 N.s8s9.01
Van-der-waals C-term R 562 - s8s9 Q 127 N.s8s9.01
Hydrophobic C-term M 776 - S6 R 72 N.S6.02
Van-der-waals C-term M 776 - S6 R 72 N.S6.02
Polar TM6 E 439 6x20 s9s10 T 154 N.s9s10.09
Hydrophobic TM6 E 439 6x20 s9s10 T 154 N.s9s10.09
Van-der-waals TM6 E 439 6x20 s9s10 T 154 N.s9s10.09
Hydrophobic ICL2 T 349 - s15s16 V 239 C.s15s16.01
Van-der-waals ICL2 T 349 - s15s16 V 239 C.s15s16.01
Hydrophobic C-term L 780 - s9s10 K 157 N.s9s10.12
Hydrophobic C-term F 787 - S8 T 125 N.S8.02
Van-der-waals C-term F 787 - S8 T 125 N.S8.02
Hydrophobic C-term D 784 - s20c E 373 C.s20c.06
Polar TM2 R 261 2x38 s5s6 L 64 N.s5s6.05
Hydrophobic TM2 R 261 2x38 s5s6 L 64 N.s5s6.05
Van-der-waals TM2 R 261 2x38 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 T 448 6x29 s5s6 I 67 N.s5s6.08
Hydrophobic TM1 D 255 1x57 s5s6 L 64 N.s5s6.05
Van-der-waals TM1 D 255 1x57 s5s6 L 64 N.s5s6.05
Hydrophobic C-term R 562 - s17s18 R 282 C.s17s18.11
Van-der-waals C-term R 562 - s17s18 R 282 C.s17s18.11
Hydrophobic TM2 L 267 2x44 s5s6 V 66 N.s5s6.07
Hydrophobic C-term T 773 - S6 F 71 N.S6.01
Van-der-waals C-term T 773 - S6 F 71 N.S6.01
Ionic TM2 R 261 2x38 s5s6 E 65 N.s5s6.06
Polar TM2 R 261 2x38 s5s6 E 65 N.s5s6.06
Hydrophobic TM2 R 261 2x38 s5s6 E 65 N.s5s6.06
Van-der-waals TM2 R 261 2x38 s5s6 E 65 N.s5s6.06
Hydrophobic TM6 T 448 6x29 s5s6 L 69 N.s5s6.10
Hydrophobic C-term F 787 - S9 C 137 N.S9.01
Van-der-waals C-term F 787 - S9 C 137 N.S9.01
Polar C-term D 784 - s17s18 K 289 C.s17s18.18
Hydrophobic C-term D 784 - s17s18 K 289 C.s17s18.18
Van-der-waals C-term D 784 - s17s18 K 289 C.s17s18.18
Polar C-term N 774 - S6 D 74 N.S6.04
Hydrophobic C-term N 774 - S6 D 74 N.S6.04
Van-der-waals C-term N 774 - S6 D 74 N.S6.04
Hydrophobic C-term F 787 - s8s9 P 136 N.s8s9.10
Van-der-waals C-term F 787 - s8s9 P 136 N.s8s9.10
Hydrophobic C-term F 787 - S5 R 58 N.S5.11
Hydrophobic C-term S 771 - S6 L 75 N.S6.05
Van-der-waals C-term S 771 - S6 L 75 N.S6.05
Hydrophobic C-term T 773 - S6 K 73 N.S6.03
Ionic C-term D 782 - s9s10 K 157 N.s9s10.12
Polar C-term D 782 - s9s10 K 157 N.s9s10.12
Van-der-waals C-term D 782 - s9s10 K 157 N.s9s10.12
Polar C-term L 780 - S10 R 162 N.S10.03
Hydrophobic C-term L 780 - S10 R 162 N.S10.03
Van-der-waals C-term L 780 - S10 R 162 N.S10.03
Polar TM6 K 444 6x25 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 K 444 6x25 s5s6 G 68 N.s5s6.09
Van-der-waals TM6 K 444 6x25 s5s6 G 68 N.s5s6.09
Hydrophobic C-term M 776 - S10 R 162 N.S10.03
Van-der-waals C-term M 776 - S10 R 162 N.S10.03
Polar C-term D 784 - s20c Q 377 C.s20c.10
Hydrophobic C-term D 784 - s20c Q 377 C.s20c.10
Van-der-waals C-term D 784 - s20c Q 377 C.s20c.10
Polar ICL2 T 348 - s15s16 Y 241 C.s15s16.03
Hydrophobic ICL2 T 348 - s15s16 Y 241 C.s15s16.03
Van-der-waals ICL2 T 348 - s15s16 Y 241 C.s15s16.03
Polar C-term K 565 - s17s18 C 279 C.s17s18.08
Hydrophobic C-term D 558 - s20c E 383 C.s20c.17
Ionic H8 R 547 8x56 s5s6 D 63 N.s5s6.04
Polar H8 R 547 8x56 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 F 343 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic C-term T 778 - s5s6 D 62 N.s5s6.03
Van-der-waals C-term T 778 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 T 349 - s15s16 L 240 C.s15s16.02
Van-der-waals ICL2 T 349 - s15s16 L 240 C.s15s16.02
Hydrophobic ICL2 G 347 - S6 F 71 N.S6.01
Van-der-waals ICL2 G 347 - S6 F 71 N.S6.01
Hydrophobic ICL1 N 258 12x49 s5s6 L 64 N.s5s6.05
Van-der-waals ICL1 N 258 12x49 s5s6 L 64 N.s5s6.05
Hydrophobic C-term T 773 - S6 R 72 N.S6.02
Van-der-waals C-term T 773 - S6 R 72 N.S6.02
Polar TM6 K 444 6x25 s5s6 T 70 N.s5s6.11
Van-der-waals TM6 K 444 6x25 s5s6 T 70 N.s5s6.11
Hydrophobic TM7 W 535 7x55 s5s6 I 67 N.s5s6.08
Hydrophobic TM2 R 261 2x38 s8s9 K 135 N.s8s9.09
Van-der-waals TM2 R 261 2x38 s8s9 K 135 N.s8s9.09
Hydrophobic C-term L 775 - S6 F 71 N.S6.01
Polar ICL2 Q 351 - S5 Y 59 N.S5.12
Hydrophobic C-term S 771 - S6 D 74 N.S6.04
Van-der-waals C-term S 771 - S6 D 74 N.S6.04
Hydrophobic TM6 K 444 6x25 s5s6 L 69 N.s5s6.10
Polar C-term F 787 - s8s9 Q 127 N.s8s9.01
Hydrophobic C-term F 787 - s8s9 Q 127 N.s8s9.01
Van-der-waals C-term F 787 - s8s9 Q 127 N.s8s9.01
Polar C-term M 776 - s5s6 T 70 N.s5s6.11
Hydrophobic TM7 V 536 7x56 s5s6 V 66 N.s5s6.07
Hydrophobic C-term L 780 - S10 Y 160 N.S10.01
Van-der-waals C-term L 780 - S10 Y 160 N.S10.01
Polar C-term D 784 - s20c S 376 C.s20c.09
Polar ICL2 T 349 - s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 T 349 - s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 T 349 - s15s16 S 242 C.s15s16.04
Ionic C-term D 782 - S10 R 162 N.S10.03
Polar C-term D 782 - S10 R 162 N.S10.03
Van-der-waals C-term D 782 - S10 R 162 N.S10.03
Hydrophobic C-term F 787 - S9 G 138 N.S9.02
Hydrophobic C-term S 785 - s17s18 K 289 C.s17s18.18
Polar C-term M 781 - s5s6 D 62 N.s5s6.03
Hydrophobic C-term M 781 - s5s6 D 62 N.s5s6.03
Van-der-waals C-term M 781 - s5s6 D 62 N.s5s6.03
Hydrophobic ICL2 L 346 - s15s16 Y 241 C.s15s16.03
Ionic C-term D 786 - s17s18 K 289 C.s17s18.18
Polar C-term D 786 - s17s18 K 289 C.s17s18.18
Hydrophobic C-term D 786 - s17s18 K 289 C.s17s18.18
Van-der-waals C-term D 786 - s17s18 K 289 C.s17s18.18