ArrestinDb

Beta-arrestin-1 - SST1 receptor complex model

Full

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

Tertiary structure confidence

Chain	pLDDT score avg
SST1	68.2
Beta-arrestin-1	80.2

Very high (>90)

Confident (90-70)

Low (70-50)

Very low (<50)

Disordered

PTM Score: 0.7

iPTM Score: 0.6

PAE mean: 16.5

GPCR - Arrestin interface interactions

The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.

Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):

bb-bb

bb-sc

sc-sc

sc-bb

Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Search:

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Interaction type	GPCR Segment	AA	Number	Generic number	Arrestin segment	AA	Number	Generic number

Hydrophobic	TM3	V	159	3x54	s5s6	L	71	N.s5s6.08
Hydrophobic	ICL1	K	90	12x51	s20c	E	404	C.s20c.14
Hydrophobic	TM5	A	257	5x72	S6	K	77	N.S6.03
Hydrophobic	H8	N	329	8x49	s5s6	D	69	N.s5s6.06
Hydrophobic	TM6	M	272	6x36	s5s6	L	71	N.s5s6.08
Hydrophobic	TM4	R	170	4x38	s8s9	E	134	N.s8s9.05
Hydrophobic	C-term	Y	354	-	S6	R	76	N.S6.02
Hydrophobic	C-term	Y	353	-	s5s6	T	74	N.s5s6.11
Hydrophobic	C-term	A	355	-	S6	K	77	N.S6.03
Hydrophobic	TM5	M	250	5x65	S6	F	75	N.S6.01
Hydrophobic	TM5	V	253	5x68	s15s16	F	244	C.s15s16.03
Hydrophobic	C-term	Y	353	-	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	E	349	-	s9s10	K	160	N.s9s10.12
Hydrophobic	C-term	Y	354	-	S6	D	78	N.S6.04
Hydrophobic	ICL2	A	166	34x54	s8s9	D	135	N.s8s9.06
Hydrophobic	TM3	V	159	3x54	S6	F	75	N.S6.01
Hydrophobic	TM3	V	159	3x54	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	T	356	-	S6	D	78	N.S6.04
Hydrophobic	TM2	T	91	2x37	s5s6	D	67	N.s5s6.04
Hydrophobic	TM2	I	97	2x43	s5s6	V	70	N.s5s6.07
Hydrophobic	TM6	V	273	6x37	s5s6	L	71	N.s5s6.08
Hydrophobic	TM6	I	269	6x33	s5s6	L	71	N.s5s6.08
Hydrophobic	TM3	A	158	3x53	s5s6	L	68	N.s5s6.05
Hydrophobic	C-term	A	347	-	s9s10	K	160	N.s9s10.12
Hydrophobic	TM4	R	170	4x38	s17s18	R	285	C.s17s18.11
Hydrophobic	ICL3	W	259	-	s15s16	F	244	C.s15s16.03
Hydrophobic	ICL2	I	163	34x51	s15s16	N	245	C.s15s16.04
Hydrophobic	TM6	M	272	6x36	s5s6	V	70	N.s5s6.07
Hydrophobic	TM2	T	93	2x39	s5s6	V	70	N.s5s6.07
Hydrophobic	C-term	D	352	-	S6	R	76	N.S6.02
Hydrophobic	C-term	E	349	-	S9	K	147	N.S9.08
Hydrophobic	ICL2	I	163	34x51	S16	A	247	C.S16.01
Hydrophobic	TM6	I	269	6x33	s5s6	L	73	N.s5s6.10
Hydrophobic	C-term	A	346	-	s9s10	H	159	N.s9s10.11
Hydrophobic	ICL3	W	259	-	S6	R	76	N.S6.02
Hydrophobic	C-term	V	351	-	s5s6	G	72	N.s5s6.09
Hydrophobic	TM3	R	155	3x50	s5s6	L	71	N.s5s6.08
Hydrophobic	C-term	Y	353	-	S6	F	75	N.S6.01
Hydrophobic	ICL2	I	163	34x51	S5	Y	63	N.S5.12
Hydrophobic	ICL2	I	163	34x51	S15	I	241	C.S15.14
Hydrophobic	ICL2	R	169	34x57	s5s6	R	65	N.s5s6.02
Hydrophobic	ICL2	P	162	34x50	S5	Y	63	N.S5.12
Hydrophobic	ICL2	I	163	34x51	S16	Y	249	C.S16.03
Hydrophobic	H8	S	327	8x47	s5s6	V	70	N.s5s6.07
Hydrophobic	C-term	Y	353	-	S6	R	76	N.S6.02
Hydrophobic	C-term	A	357	-	S6	D	78	N.S6.04
Hydrophobic	C-term	E	349	-	S10	R	165	N.S10.03
Hydrophobic	C-term	E	348	-	s9s10	K	160	N.s9s10.12
Hydrophobic	ICL2	A	166	34x54	s5s6	R	65	N.s5s6.02
Hydrophobic	C-term	D	352	-	s5s6	T	74	N.s5s6.11
Hydrophobic	H8	R	336	8x56	s20c	E	407	C.s20c.17
Ionic	ICL1	K	90	12x51	s20c	E	404	C.s20c.14
Ionic	TM5	K	256	5x71	s17s18	E	313	C.s17s18.39
Ionic	ICL2	R	169	34x57	s5s6	D	67	N.s5s6.04
Ionic	TM4	R	170	4x38	s8s9	E	134	N.s8s9.05
Ionic	C-term	E	348	-	s9s10	K	157	N.s9s10.09
Ionic	C-term	D	352	-	S5	R	62	N.S5.11
Ionic	TM4	R	170	4x38	s8s9	D	135	N.s8s9.06
Ionic	C-term	D	352	-	S6	R	76	N.S6.02
Ionic	C-term	E	349	-	S9	K	147	N.S9.08
Ionic	C-term	E	349	-	S10	R	165	N.S10.03
Ionic	ICL1	K	90	12x51	s20c	D	402	C.s20c.12
Ionic	H8	R	336	8x56	s20c	E	407	C.s20c.17
Polar	TM5	K	249	5x64	s15s16	F	244	C.s15s16.03
Polar	ICL1	K	90	12x51	s20c	E	404	C.s20c.14
Polar	H8	N	329	8x49	s5s6	D	69	N.s5s6.06
Polar	TM5	K	256	5x71	s17s18	E	313	C.s17s18.39
Polar	ICL2	R	169	34x57	s5s6	D	67	N.s5s6.04
Polar	TM4	R	170	4x38	s8s9	E	134	N.s8s9.05
Polar	C-term	Y	354	-	S6	R	76	N.S6.02
Polar	C-term	Y	353	-	s5s6	T	74	N.s5s6.11
Polar	C-term	E	348	-	s9s10	K	157	N.s9s10.09
Polar	TM3	V	160	3x55	s15s16	N	245	C.s15s16.04
Polar	C-term	A	355	-	S6	R	76	N.S6.02
Polar	C-term	D	352	-	S5	R	62	N.S5.11
Polar	TM4	R	170	4x38	s8s9	D	135	N.s8s9.06
Polar	TM4	T	172	4x40	s8s9	E	134	N.s8s9.05
Polar	TM3	R	155	3x50	s5s6	V	70	N.s5s6.07
Polar	C-term	A	355	-	S6	D	78	N.S6.04
Polar	H8	S	327	8x47	s5s6	D	69	N.s5s6.06
Polar	C-term	D	352	-	S6	R	76	N.S6.02
Polar	C-term	E	349	-	S9	K	147	N.S9.08
Polar	C-term	V	351	-	s5s6	G	72	N.s5s6.09
Polar	ICL2	I	163	34x51	S5	Y	63	N.S5.12
Polar	ICL2	R	169	34x57	s5s6	R	65	N.s5s6.02
Polar	ICL2	P	162	34x50	S5	Y	63	N.S5.12
Polar	ICL2	I	163	34x51	S16	Y	249	C.S16.03
Polar	C-term	Y	353	-	S6	R	76	N.S6.02
Polar	C-term	A	357	-	S6	D	78	N.S6.04
Polar	C-term	E	349	-	S10	R	165	N.S10.03
Polar	ICL2	A	166	34x54	s5s6	R	65	N.s5s6.02
Polar	C-term	D	352	-	s5s6	T	74	N.s5s6.11
Polar	ICL1	K	90	12x51	s20c	D	402	C.s20c.12
Polar	H8	R	336	8x56	s20c	E	407	C.s20c.17
Van-der-waals	TM5	K	249	5x64	s15s16	F	244	C.s15s16.03
Van-der-waals	ICL1	K	90	12x51	s20c	E	404	C.s20c.14
Van-der-waals	H8	N	329	8x49	s5s6	D	69	N.s5s6.06
Van-der-waals	TM6	M	272	6x36	s5s6	L	71	N.s5s6.08
Van-der-waals	TM5	K	256	5x71	s17s18	E	313	C.s17s18.39
Van-der-waals	ICL2	R	169	34x57	s5s6	D	67	N.s5s6.04
Van-der-waals	TM4	R	170	4x38	s8s9	E	134	N.s8s9.05
Van-der-waals	C-term	Y	354	-	S6	R	76	N.S6.02
Van-der-waals	C-term	Y	353	-	s5s6	T	74	N.s5s6.11
Van-der-waals	C-term	A	355	-	S6	K	77	N.S6.03
Van-der-waals	TM5	M	250	5x65	S6	F	75	N.S6.01
Van-der-waals	C-term	E	348	-	s9s10	K	157	N.s9s10.09
Van-der-waals	TM3	V	160	3x55	s15s16	N	245	C.s15s16.04
Van-der-waals	TM5	V	253	5x68	s15s16	F	244	C.s15s16.03
Van-der-waals	C-term	Y	353	-	s5s6	L	73	N.s5s6.10
Van-der-waals	C-term	A	355	-	S6	R	76	N.S6.02
Van-der-waals	C-term	Y	354	-	S6	D	78	N.S6.04
Van-der-waals	ICL2	A	166	34x54	s8s9	D	135	N.s8s9.06
Van-der-waals	C-term	D	352	-	S5	R	62	N.S5.11
Van-der-waals	TM3	V	159	3x54	s5s6	L	73	N.s5s6.10
Van-der-waals	TM2	T	91	2x37	s5s6	D	67	N.s5s6.04
Van-der-waals	TM4	R	170	4x38	s8s9	D	135	N.s8s9.06
Van-der-waals	TM6	I	269	6x33	s5s6	L	71	N.s5s6.08
Van-der-waals	TM3	A	158	3x53	s5s6	L	68	N.s5s6.05
Van-der-waals	C-term	A	347	-	s9s10	K	160	N.s9s10.12
Van-der-waals	TM4	R	170	4x38	s17s18	R	285	C.s17s18.11
Van-der-waals	ICL3	W	259	-	s15s16	F	244	C.s15s16.03
Van-der-waals	TM3	R	155	3x50	s5s6	V	70	N.s5s6.07
Van-der-waals	ICL2	I	163	34x51	s15s16	N	245	C.s15s16.04
Van-der-waals	C-term	A	355	-	S6	D	78	N.S6.04
Van-der-waals	TM6	M	272	6x36	s5s6	V	70	N.s5s6.07
Van-der-waals	TM2	T	93	2x39	s5s6	V	70	N.s5s6.07
Van-der-waals	C-term	D	352	-	S6	R	76	N.S6.02
Van-der-waals	C-term	E	349	-	S9	K	147	N.S9.08
Van-der-waals	ICL2	I	163	34x51	S16	A	247	C.S16.01
Van-der-waals	TM6	I	269	6x33	s5s6	L	73	N.s5s6.10
Van-der-waals	C-term	A	346	-	s9s10	H	159	N.s9s10.11
Van-der-waals	ICL3	W	259	-	S6	R	76	N.S6.02
Van-der-waals	C-term	V	351	-	s5s6	G	72	N.s5s6.09
Van-der-waals	TM3	R	155	3x50	s5s6	L	71	N.s5s6.08
Van-der-waals	ICL2	I	163	34x51	S5	Y	63	N.S5.12
Van-der-waals	ICL2	I	163	34x51	S15	I	241	C.S15.14
Van-der-waals	ICL2	R	169	34x57	s5s6	R	65	N.s5s6.02
Van-der-waals	ICL2	P	162	34x50	S5	Y	63	N.S5.12
Van-der-waals	ICL2	I	163	34x51	S16	Y	249	C.S16.03
Van-der-waals	C-term	Y	353	-	S6	R	76	N.S6.02
Van-der-waals	C-term	A	357	-	S6	D	78	N.S6.04
Van-der-waals	C-term	E	349	-	S10	R	165	N.S10.03
Van-der-waals	ICL2	A	166	34x54	s5s6	R	65	N.s5s6.02
Van-der-waals	C-term	D	352	-	s5s6	T	74	N.s5s6.11
Van-der-waals	ICL1	K	90	12x51	s20c	D	402	C.s20c.12
Van-der-waals	H8	R	336	8x56	s20c	E	407	C.s20c.17

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Main reference

Beta-arrestin-1 - SST1 receptor complex model Download Full