Beta-arrestin-2 - SST1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
SST1 67.2
Beta-arrestin-2 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic C-term L 358 - S6 I 82 N.S6.07
Hydrophobic TM3 V 159 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 V 253 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 V 253 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL1 K 90 12x51 s20c Y 404 C.s20c.14
Ionic TM5 K 256 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 256 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 256 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 I 163 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 163 34x51 S15 I 242 C.S15.14
Hydrophobic TM2 T 91 2x37 s5s6 D 68 N.s5s6.04
Polar C-term Y 353 - s9s10 S 159 N.s9s10.10
Polar ICL2 I 163 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 163 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 I 163 34x51 S16 Y 250 C.S16.03
Polar ICL2 P 162 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 162 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 162 34x50 S5 Y 64 N.S5.12
Hydrophobic TM4 R 170 4x38 s17s18 R 286 C.s17s18.11
Van-der-waals TM4 R 170 4x38 s17s18 R 286 C.s17s18.11
Hydrophobic TM4 P 171 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 P 171 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 M 250 5x65 S6 F 76 N.S6.01
Hydrophobic C-term P 350 - s9s10 K 158 N.s9s10.09
Hydrophobic TM3 V 159 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 159 3x54 s5s6 L 74 N.s5s6.10
Aromatic ICL3 R 262 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 R 262 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 R 262 - s15s16 F 245 C.s15s16.03
Hydrophobic TM6 M 272 6x36 s5s6 L 72 N.s5s6.08
Ionic ICL2 R 169 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 169 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 169 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 I 269 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 I 269 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 A 257 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic TM2 T 93 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 93 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic H8 S 327 8x47 s5s6 V 71 N.s5s6.07
Polar C-term E 348 - s9s10 R 162 N.s9s10.13
Hydrophobic C-term E 348 - s9s10 R 162 N.s9s10.13
Van-der-waals C-term E 348 - s9s10 R 162 N.s9s10.13
Hydrophobic TM3 A 158 3x53 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 A 158 3x53 s5s6 L 69 N.s5s6.05
Hydrophobic ICL2 I 163 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 I 163 34x51 S16 A 248 C.S16.01
Polar TM1 Y 86 1x60 s20c Y 404 C.s20c.14
Van-der-waals TM1 Y 86 1x60 s20c Y 404 C.s20c.14
Hydrophobic C-term V 351 - s9s10 K 161 N.s9s10.12
Polar ICL3 R 262 - S6 R 77 N.S6.02
Van-der-waals ICL3 R 262 - S6 R 77 N.S6.02
Polar ICL2 I 163 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 I 163 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 I 163 34x51 S5 Y 64 N.S5.12
Hydrophobic TM2 I 97 2x43 s5s6 V 71 N.s5s6.07
Polar ICL2 A 166 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 166 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 166 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 M 250 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 M 250 5x65 s5s6 L 74 N.s5s6.10
Polar C-term Y 353 - S6 D 79 N.S6.04
Hydrophobic C-term Y 353 - S6 D 79 N.S6.04
Van-der-waals C-term Y 353 - S6 D 79 N.S6.04
Hydrophobic C-term V 351 - S10 R 166 N.S10.03
Van-der-waals C-term V 351 - S10 R 166 N.S10.03
Ionic C-term E 349 - s9s10 K 161 N.s9s10.12
Polar C-term E 349 - s9s10 K 161 N.s9s10.12
Van-der-waals C-term E 349 - s9s10 K 161 N.s9s10.12
Polar C-term E 348 - s9s10 K 161 N.s9s10.12
Polar C-term Y 353 - S9 R 148 N.S9.08
Van-der-waals C-term Y 353 - S9 R 148 N.S9.08
Hydrophobic TM6 I 269 6x33 s5s6 G 73 N.s5s6.09
Van-der-waals TM6 I 269 6x33 s5s6 G 73 N.s5s6.09
Polar TM5 A 257 5x72 S6 K 78 N.S6.03
Hydrophobic TM5 A 257 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 A 257 5x72 S6 K 78 N.S6.03
Hydrophobic TM6 I 269 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 269 6x33 s5s6 L 74 N.s5s6.10
Polar C-term Y 354 - s9s10 K 158 N.s9s10.09
Hydrophobic C-term Y 354 - s9s10 K 158 N.s9s10.09
Van-der-waals C-term Y 354 - s9s10 K 158 N.s9s10.09
Polar C-term Y 353 - S6 R 77 N.S6.02
Aromatic C-term Y 353 - S6 R 77 N.S6.02
Hydrophobic C-term Y 353 - S6 R 77 N.S6.02
Van-der-waals C-term Y 353 - S6 R 77 N.S6.02
Polar TM5 K 249 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 K 249 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 249 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic C-term V 351 - S9 R 148 N.S9.08
Van-der-waals C-term V 351 - S9 R 148 N.S9.08
Hydrophobic ICL2 I 163 34x51 s15s16 S 246 C.s15s16.04
Polar ICL3 R 262 - S6 F 76 N.S6.01
Hydrophobic ICL3 R 262 - S6 F 76 N.S6.01
Van-der-waals ICL3 R 262 - S6 F 76 N.S6.01
Hydrophobic ICL2 P 162 34x50 s15s16 S 246 C.s15s16.04
Polar TM2 T 93 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 R 155 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 155 3x50 s5s6 L 72 N.s5s6.08
Ionic C-term E 348 - s9s10 H 160 N.s9s10.11
Polar C-term E 348 - s9s10 H 160 N.s9s10.11
Hydrophobic C-term E 348 - s9s10 H 160 N.s9s10.11
Van-der-waals C-term E 348 - s9s10 H 160 N.s9s10.11
Polar TM4 T 172 4x40 s8s9 E 135 N.s8s9.05
Polar ICL3 S 265 - s5s6 G 73 N.s5s6.09
Van-der-waals ICL3 S 265 - s5s6 G 73 N.s5s6.09
Hydrophobic TM3 V 159 3x54 S6 F 76 N.S6.01
Van-der-waals TM3 V 159 3x54 S6 F 76 N.S6.01
Polar ICL2 R 169 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 R 169 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 169 34x57 s5s6 R 66 N.s5s6.02
Ionic ICL1 K 90 12x51 s20c D 402 C.s20c.12
Polar ICL1 K 90 12x51 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 90 12x51 s20c D 402 C.s20c.12
Polar C-term V 351 - s9s10 S 159 N.s9s10.10