S-arrestin - SST1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
SST1 66.3
S-arrestin 80.1
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 A 257 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 A 257 5x72 S6 R 85 N.S6.03
Polar ICL2 I 163 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 V 159 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 159 3x54 S6 F 83 N.S6.01
Hydrophobic TM6 I 269 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 I 269 6x33 s5s6 L 81 N.s5s6.10
Hydrophobic TM2 N 94 2x40 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 N 94 2x40 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 M 272 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 M 272 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic ICL3 W 259 - S6 R 85 N.S6.03
Van-der-waals ICL3 W 259 - S6 R 85 N.S6.03
Hydrophobic ICL3 Q 261 - S6 F 89 N.S6.07
Van-der-waals ICL3 Q 261 - S6 F 89 N.S6.07
Hydrophobic TM5 V 253 5x68 s15s16 Y 254 C.s15s16.03
Polar ICL2 I 163 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 I 163 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 I 163 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 I 163 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 I 163 34x51 S16 D 257 C.S16.01
Hydrophobic TM3 R 155 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 155 3x50 s5s6 I 79 N.s5s6.08
Polar ICL3 R 262 - S6 R 84 N.S6.02
Hydrophobic ICL3 R 262 - S6 R 84 N.S6.02
Van-der-waals ICL3 R 262 - S6 R 84 N.S6.02
Hydrophobic ICL2 A 166 34x54 s8s9 G 144 N.s8s9.08
Ionic ICL3 R 264 - s9s10 E 164 N.s9s10.06
Polar ICL3 R 264 - s9s10 E 164 N.s9s10.06
Hydrophobic ICL3 R 264 - s9s10 E 164 N.s9s10.06
Van-der-waals ICL3 R 264 - s9s10 E 164 N.s9s10.06
Hydrophobic H8 N 329 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 329 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic ICL2 P 162 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 162 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL2 I 163 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 I 163 34x51 S5 Y 71 N.S5.12
Ionic ICL2 K 164 34x52 S16 D 257 C.S16.01
Polar ICL2 K 164 34x52 S16 D 257 C.S16.01
Hydrophobic ICL2 K 164 34x52 S16 D 257 C.S16.01
Van-der-waals ICL2 K 164 34x52 S16 D 257 C.S16.01
Polar TM5 K 249 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 249 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 249 5x64 s15s16 Y 254 C.s15s16.03
Polar ICL2 P 162 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 162 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 162 34x50 S5 Y 71 N.S5.12
Polar ICL3 R 262 - s15s16 Y 254 C.s15s16.03
Hydrophobic TM3 V 159 3x54 s5s6 L 81 N.s5s6.10
Polar ICL3 R 262 - s5s6 T 82 N.s5s6.11
Van-der-waals ICL3 R 262 - s5s6 T 82 N.s5s6.11
Ionic TM5 K 256 5x71 s17s18 D 321 C.s17s18.37
Ionic TM4 R 170 4x38 s8s9 D 142 N.s8s9.06
Polar TM4 R 170 4x38 s8s9 D 142 N.s8s9.06
Hydrophobic TM4 R 170 4x38 s8s9 D 142 N.s8s9.06
Van-der-waals TM4 R 170 4x38 s8s9 D 142 N.s8s9.06
Hydrophobic ICL2 I 163 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 I 163 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 R 169 34x57 s5s6 I 76 N.s5s6.05
Van-der-waals ICL2 R 169 34x57 s5s6 I 76 N.s5s6.05
Ionic C-term E 349 - s1s2 R 22 N.s1s2.02
Polar C-term E 349 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term E 349 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term E 349 - s1s2 R 22 N.s1s2.02
Hydrophobic TM6 I 269 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 I 97 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 I 97 2x43 s5s6 V 78 N.s5s6.07
Polar ICL3 Q 261 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 Q 261 - s9s10 A 163 N.s9s10.05
Hydrophobic TM3 A 158 3x53 S6 F 83 N.S6.01
Van-der-waals TM3 A 158 3x53 S6 F 83 N.S6.01
Hydrophobic C-term T 356 - s8s9 S 143 N.s8s9.07
Hydrophobic ICL3 R 262 - S6 R 85 N.S6.03
Polar TM5 V 253 5x68 S6 R 85 N.S6.03
Hydrophobic TM5 V 253 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 V 253 5x68 S6 R 85 N.S6.03
Hydrophobic ICL2 P 162 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 R 167 34x55 s8s9 K 145 N.s8s9.09
Ionic ICL3 R 264 - s9s10 D 166 N.s9s10.08
Polar ICL3 R 264 - s9s10 D 166 N.s9s10.08
Van-der-waals ICL3 R 264 - s9s10 D 166 N.s9s10.08
Hydrophobic TM3 R 155 3x50 s5s6 L 81 N.s5s6.10
Polar H8 S 327 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 327 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic ICL3 R 262 - S6 F 83 N.S6.01
Hydrophobic TM3 H 161 3x56 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 I 269 6x33 s5s6 G 80 N.s5s6.09
Hydrophobic H8 F 330 8x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM2 T 93 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 93 2x39 s5s6 V 78 N.s5s6.07
Polar H8 S 327 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 S 327 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 S 327 8x47 s5s6 V 78 N.s5s6.07
Polar ICL2 A 166 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 166 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 166 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM2 T 91 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic TM2 T 93 2x39 s5s6 I 79 N.s5s6.08
Ionic C-term K 359 - s20c D 389 C.s20c.08
Polar C-term K 359 - s20c D 389 C.s20c.08
Van-der-waals C-term K 359 - s20c D 389 C.s20c.08
Polar TM5 K 256 5x71 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 K 256 5x71 s17s18 T 323 C.s17s18.39
Polar ICL3 W 259 - S6 D 86 N.S6.04
Hydrophobic ICL3 W 259 - S6 D 86 N.S6.04
Van-der-waals ICL3 W 259 - S6 D 86 N.S6.04
Polar TM5 K 256 5x71 S6 R 85 N.S6.03
Van-der-waals TM5 K 256 5x71 S6 R 85 N.S6.03