Beta-arrestin-2 - SST2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
SST2 75.3
Beta-arrestin-2 80.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL1 K 73 12x49 s20c D 402 C.s20c.12
Polar ICL1 K 73 12x49 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 73 12x49 s20c D 402 C.s20c.12
Hydrophobic ICL1 K 75 12x51 s8s9 T 137 N.s8s9.07
Polar ICL2 R 154 34x57 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 R 154 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic H8 S 316 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 140 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 T 78 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 78 2x39 s5s6 V 71 N.s5s6.07
Polar H8 N 318 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic ICL3 V 242 - S6 K 78 N.S6.03
Van-der-waals ICL3 V 242 - S6 K 78 N.S6.03
Polar ICL2 A 151 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 151 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 151 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL3 V 242 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 V 242 - s15s16 F 245 C.s15s16.03
Hydrophobic TM6 M 257 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 M 257 6x36 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 R 247 6x26 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 R 247 6x26 s15s16 F 245 C.s15s16.03
Polar H8 N 318 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic H8 N 318 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 N 318 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic ICL2 I 148 34x51 S15 I 242 C.S15.14
Van-der-waals ICL2 I 148 34x51 S15 I 242 C.S15.14
Hydrophobic ICL2 K 149 34x52 S16 A 248 C.S16.01
Hydrophobic ICL2 K 152 34x55 S16 Y 250 C.S16.03
Hydrophobic TM3 A 143 3x53 s5s6 L 69 N.s5s6.05
Ionic ICL2 R 154 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 154 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 154 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 154 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 V 144 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 144 3x54 s5s6 L 69 N.s5s6.05
Polar TM4 R 157 4x40 s8s9 E 135 N.s8s9.05
Hydrophobic TM2 T 78 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 78 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM5 I 231 5x61 s5s6 L 72 N.s5s6.08
Polar TM5 K 234 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 K 234 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 234 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM2 T 76 2x37 s8s9 T 137 N.s8s9.07
Polar ICL2 I 148 34x51 S16 Y 250 C.S16.03
Hydrophobic ICL2 I 148 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 I 148 34x51 S16 Y 250 C.S16.03
Hydrophobic TM3 R 140 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 140 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 235 5x65 s5s6 L 74 N.s5s6.10
Polar ICL3 R 241 - S6 K 78 N.S6.03
Van-der-waals ICL3 R 241 - S6 K 78 N.S6.03
Hydrophobic ICL2 I 148 34x51 s15s16 S 246 C.s15s16.04
Ionic ICL1 K 75 12x51 s20c D 402 C.s20c.12
Polar ICL1 K 75 12x51 s20c D 402 C.s20c.12
Van-der-waals ICL1 K 75 12x51 s20c D 402 C.s20c.12
Hydrophobic TM6 M 257 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 257 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 V 254 6x33 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 254 6x33 s5s6 L 72 N.s5s6.08
Hydrophobic ICL1 K 73 12x49 s20c Y 404 C.s20c.14
Van-der-waals ICL1 K 73 12x49 s20c Y 404 C.s20c.14
Hydrophobic TM3 V 144 3x54 S6 F 76 N.S6.01
Ionic ICL3 R 241 - s17s18 E 314 C.s17s18.39
Polar ICL3 R 241 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 R 241 - s17s18 E 314 C.s17s18.39
Polar TM6 S 250 6x29 s5s6 G 73 N.s5s6.09
Hydrophobic TM3 V 144 3x54 s5s6 L 74 N.s5s6.10
Polar ICL2 I 148 34x51 S5 Y 64 N.S5.12
Hydrophobic ICL2 I 148 34x51 S5 Y 64 N.S5.12
Van-der-waals ICL2 I 148 34x51 S5 Y 64 N.S5.12
Hydrophobic TM5 S 238 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 S 238 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 I 148 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 I 148 34x51 S16 A 248 C.S16.01
Hydrophobic TM6 V 254 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 254 6x33 s5s6 L 74 N.s5s6.10
Polar TM4 P 156 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 P 156 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 P 156 4x39 s8s9 E 135 N.s8s9.05
Polar ICL2 P 147 34x50 S5 Y 64 N.S5.12
Hydrophobic ICL2 P 147 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 147 34x50 S5 Y 64 N.S5.12
Hydrophobic TM3 V 144 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 V 144 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 P 147 34x50 s15s16 S 246 C.s15s16.04