Gz - SST2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2024-05-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
SST2 78.9
Gαz 88.5
Gβ1 93.9
Gγ2 81.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 10.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 246 6x25 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 K 246 6x25 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 K 246 6x25 G.h4s6 K 315 G.h4s6.08
Ionic ICL3 R 241 - G.H5 D 338 G.H5.09
Polar ICL3 R 241 - G.H5 D 338 G.H5.09
Hydrophobic ICL3 R 241 - G.H5 D 338 G.H5.09
Hydrophobic ICL2 P 147 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM6 V 258 6x37 G.H5 L 354 G.H5.25
Hydrophobic C-term I 369 - G.H2 W 212 G.H2.07
Hydrophobic TM2 T 78 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM6 M 257 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 M 257 6x36 G.H5 G 353 G.H5.24
Hydrophobic C-term I 369 - G.H2 R 209 G.H2.04
Van-der-waals C-term I 369 - G.H2 R 209 G.H2.04
Polar TM6 S 244 6x23 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 244 6x23 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 244 6x23 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM5 S 238 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 S 238 5x68 G.H5 I 345 G.H5.16
Hydrophobic C-term S 368 - G.H2 R 206 G.H2.01
Van-der-waals C-term S 368 - G.H2 R 206 G.H2.01
Hydrophobic TM5 V 235 5x65 G.H5 L 349 G.H5.20
Polar C-term I 369 - G.s3h2 Q 205 G.s3h2.03
Hydrophobic TM6 M 257 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 257 6x36 G.H5 L 354 G.H5.25
Hydrophobic H8 S 316 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL2 P 147 34x50 G.H5 T 341 G.H5.12
Hydrophobic C-term I 369 - G.H3 L 250 G.H3.08
Van-der-waals C-term I 369 - G.H3 L 250 G.H3.08
Ionic TM6 R 247 6x26 G.H5 D 342 G.H5.13
Polar TM6 R 247 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 247 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 247 6x26 G.H5 D 342 G.H5.13
Ionic TM6 R 247 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 247 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 247 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 247 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 R 140 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 140 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 K 152 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 A 143 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 143 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 143 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 K 253 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 253 6x32 G.H5 C 355 G.H5.26
Polar C-term T 356 - G.H3 N 258 G.H3.16
Hydrophobic TM5 I 231 5x61 G.H5 L 354 G.H5.25
Polar TM5 S 238 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 S 238 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 S 238 5x68 G.H5 D 342 G.H5.13
Polar TM3 R 140 3x50 G.H5 G 353 G.H5.24
Hydrophobic ICL3 V 242 - G.S6 Y 321 G.S6.02
Hydrophobic ICL2 I 148 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 I 148 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM3 V 144 3x54 G.H5 I 352 G.H5.23
Hydrophobic TM3 V 144 3x54 G.H5 I 345 G.H5.16
Polar TM6 R 247 6x26 G.S6 Y 321 G.S6.02
Hydrophobic TM6 R 247 6x26 G.S6 Y 321 G.S6.02
Van-der-waals TM6 R 247 6x26 G.S6 Y 321 G.S6.02
Hydrophobic C-term I 369 - G.H1 K 46 G.H1.01
Van-der-waals C-term I 369 - G.H1 K 46 G.H1.01
Polar C-term T 367 - G.H2 R 209 G.H2.04
Van-der-waals C-term T 367 - G.H2 R 209 G.H2.04
Hydrophobic C-term T 367 - G.H2 R 209 G.H2.04
Hydrophobic ICL3 V 242 - G.H5 A 339 G.H5.10
Polar C-term T 353 - G.H3 N 258 G.H3.16
Polar TM6 K 246 6x25 G.h4s6 K 318 G.h4s6.11
Van-der-waals TM6 K 246 6x25 G.h4s6 K 318 G.h4s6.11
Hydrophobic ICL3 V 242 - G.H5 D 342 G.H5.13
Hydrophobic TM3 V 144 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 144 3x54 G.H5 L 349 G.H5.20
Hydrophobic C-term I 369 - G.s3h2 G 203 G.s3h2.01
Van-der-waals C-term I 369 - G.s3h2 G 203 G.s3h2.01
Hydrophobic C-term I 369 - G.S1 L 39 G.S1.07
Hydrophobic TM7 L 315 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 L 315 7x56 G.H5 G 353 G.H5.24
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 147 34x50 G.H5 I 344 G.H5.15
Hydrophobic C-term I 369 - G.s1h1 G 40 G.s1h1.01
Van-der-waals C-term I 369 - G.s1h1 G 40 G.s1h1.01
Polar TM3 R 140 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 I 352 G.H5.23
Hydrophobic C-term R 349 - G.h3s5 I 261 G.h3s5.01
Hydrophobic TM5 K 234 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 K 234 5x64 G.H5 I 345 G.H5.16
Ionic ICL2 K 149 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 K 149 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 K 149 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 K 149 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic TM3 A 143 3x53 G.H5 I 352 G.H5.23
Hydrophobic C-term T 367 - G.H3 E 246 G.H3.04
Van-der-waals C-term T 367 - G.H3 E 246 G.H3.04
Polar TM6 S 250 6x29 G.H5 Q 346 G.H5.17
Hydrophobic ICL2 I 148 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 I 148 34x51 G.S3 L 195 G.S3.01
Van-der-waals TM4 R 155 4x38 G.hns1 R 32 G.hns1.03
Ionic C-term D 364 - G.H3 R 249 G.H3.07
Polar C-term D 364 - G.H3 R 249 G.H3.07
Van-der-waals C-term D 364 - G.H3 R 249 G.H3.07
Hydrophobic TM6 V 254 6x33 G.H5 L 349 G.H5.20
Ionic C-term R 349 - G.h2s4 E 217 G.h2s4.02
Polar C-term R 349 - G.h2s4 E 217 G.h2s4.02
Hydrophobic ICL3 V 242 - G.H5 D 338 G.H5.09
Polar C-term I 369 - G.s3h2 G 204 G.s3h2.02
Van-der-waals C-term I 369 - G.s3h2 G 204 G.s3h2.02
Polar TM2 T 78 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 T 78 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM6 V 254 6x33 G.H5 L 354 G.H5.25
Polar C-term L 365 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 365 - G.H2 R 209 G.H2.04
Van-der-waals C-term L 365 - G.H2 R 209 G.H2.04
Hydrophobic C-term Q 357 - G.H2 K 210 G.H2.05
Polar ICL3 G 239 - G.H5 D 342 G.H5.13
Polar C-term S 368 - G.s1h1 S 42 G.s1h1.03
Van-der-waals C-term I 369 - G.S3 V 202 G.S3.08
Van-der-waals C-term Q 366 - G.H2 R 206 G.H2.01
Hydrophobic C-term L 350 - G.H3 W 259 G.H3.17
Hydrophobic C-term L 365 - G.s4h3 T 241 G.s4h3.14
Hydrophobic C-term L 365 - G.s4h3 L 235 G.s4h3.08
Polar C-term Q 366 - G.H2 E 208 G.H2.03
Ionic ICL2 K 152 34x55 G.s2s3 E 194 G.s2s3.02
Polar H8 N 318 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 N 318 8x49 G.H5 K 350 G.H5.21
Hydrophobic C-term L 361 - G.H2 K 210 G.H2.05
Van-der-waals C-term L 361 - G.H2 K 210 G.H2.05
Hydrophobic C-term I 369 - G.H3 I 254 G.H3.12
Hydrophobic H8 D 317 8x48 G.H5 C 355 G.H5.26