Beta-arrestin-2 - SST3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
SST3 65.9
Beta-arrestin-2 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.2


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 I 229 5x61 s5s6 L 72 N.s5s6.08
Polar ICL1 S 75 12x50 s8s9 T 137 N.s8s9.07
Hydrophobic ICL1 S 75 12x50 s8s9 T 137 N.s8s9.07
Van-der-waals ICL1 S 75 12x50 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 K 232 5x64 s15s16 S 246 C.s15s16.04
Hydrophobic TM3 R 141 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 R 141 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 V 233 5x65 s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 A 242 - S6 K 78 N.S6.03
Van-der-waals ICL3 A 242 - S6 K 78 N.S6.03
Polar ICL2 A 152 34x54 s5s6 R 66 N.s5s6.02
Hydrophobic ICL2 A 152 34x54 s5s6 R 66 N.s5s6.02
Van-der-waals ICL2 A 152 34x54 s5s6 R 66 N.s5s6.02
Polar H8 Y 318 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 Y 318 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 I 229 5x61 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 A 236 5x68 S6 F 76 N.S6.01
Hydrophobic ICL2 T 149 34x51 S16 A 248 C.S16.01
Van-der-waals ICL2 T 149 34x51 S16 A 248 C.S16.01
Hydrophobic TM6 V 255 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 V 255 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 M 258 6x36 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 M 258 6x36 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 I 83 2x43 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 A 144 3x53 s5s6 L 69 N.s5s6.05
Polar TM4 A 157 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 A 157 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 V 145 3x54 s15s16 F 245 C.s15s16.03
Van-der-waals TM3 V 145 3x54 s15s16 F 245 C.s15s16.03
Polar TM2 S 77 2x37 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 S 77 2x37 s5s6 D 68 N.s5s6.04
Hydrophobic ICL3 A 242 - S6 D 79 N.S6.04
Van-der-waals ICL3 A 242 - S6 D 79 N.S6.04
Hydrophobic TM3 V 145 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 V 145 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 V 145 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 V 145 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic ICL2 P 148 34x50 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 P 148 34x50 s15s16 S 246 C.s15s16.04
Polar ICL2 R 155 34x57 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 Y 226 5x58 s5s6 L 72 N.s5s6.08
Van-der-waals TM5 Y 226 5x58 s5s6 L 72 N.s5s6.08
Hydrophobic H8 R 319 8x49 s5s6 D 70 N.s5s6.06
Van-der-waals H8 R 319 8x49 s5s6 D 70 N.s5s6.06
Hydrophobic TM5 V 233 5x65 s5s6 L 74 N.s5s6.10
Van-der-waals TM5 V 233 5x65 s5s6 L 74 N.s5s6.10
Hydrophobic H8 S 317 8x47 s5s6 V 71 N.s5s6.07
Ionic ICL3 R 247 - S6 D 79 N.S6.04
Polar ICL3 R 247 - S6 D 79 N.S6.04
Van-der-waals ICL3 R 247 - S6 D 79 N.S6.04
Hydrophobic TM5 A 236 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 A 236 5x68 s15s16 F 245 C.s15s16.03
Polar TM5 K 232 5x64 s15s16 F 245 C.s15s16.03
Aromatic TM5 K 232 5x64 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 K 232 5x64 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 K 232 5x64 s15s16 F 245 C.s15s16.03
Ionic H8 R 319 8x49 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 V 145 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 V 240 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 V 240 5x72 S6 K 78 N.S6.03
Polar H8 R 319 8x49 s8s9 T 137 N.s8s9.07
Van-der-waals H8 R 319 8x49 s8s9 T 137 N.s8s9.07
Ionic TM5 R 239 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 R 239 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 R 239 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 R 239 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL2 P 148 34x50 S5 Y 64 N.S5.12
Van-der-waals ICL2 P 148 34x50 S5 Y 64 N.S5.12
Hydrophobic TM5 V 240 5x72 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 V 240 5x72 s15s16 L 244 C.s15s16.02
Hydrophobic TM2 T 79 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 T 79 2x39 s5s6 V 71 N.s5s6.07
Ionic ICL2 R 155 34x57 s5s6 D 68 N.s5s6.04
Polar ICL2 R 155 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 R 155 34x57 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 R 155 34x57 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 M 258 6x36 s5s6 V 71 N.s5s6.07
Van-der-waals TM6 M 258 6x36 s5s6 V 71 N.s5s6.07
Polar TM2 T 79 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 T 79 2x39 s5s6 D 68 N.s5s6.04
Van-der-waals TM2 T 79 2x39 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 T 149 34x51 S15 I 242 C.S15.14
Hydrophobic TM4 T 156 4x38 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 T 156 4x38 s8s9 E 135 N.s8s9.05
Hydrophobic TM7 Y 313 7x53 s5s6 V 71 N.s5s6.07
Van-der-waals TM7 Y 313 7x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM5 V 240 5x72 S6 F 76 N.S6.01
Aromatic H8 R 326 8x56 s20c Y 404 C.s20c.14
Polar ICL3 S 244 - S6 D 79 N.S6.04
Hydrophobic ICL3 S 244 - S6 D 79 N.S6.04
Ionic H8 R 319 8x49 s5s6 E 67 N.s5s6.03
Polar H8 R 319 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 R 319 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 R 319 8x49 s5s6 E 67 N.s5s6.03
Polar TM3 R 141 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 R 141 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 R 141 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 T 149 34x51 S16 Y 250 C.S16.03
Van-der-waals ICL2 T 149 34x51 S16 Y 250 C.S16.03