S-arrestin - SST4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
SST4 70.8
S-arrestin 81.0
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 148 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 A 147 3x53 s5s6 I 76 N.s5s6.05
Ionic C-term D 345 - S1 K 19 N.S1.04
Polar C-term D 345 - S1 K 19 N.S1.04
Van-der-waals C-term D 345 - S1 K 19 N.S1.04
Polar C-term E 340 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term E 340 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term E 340 - s1s2 R 22 N.s1s2.02
Polar C-term Y 346 - s17s18 H 305 C.s17s18.21
Aromatic C-term Y 346 - s17s18 H 305 C.s17s18.21
Hydrophobic C-term Y 346 - s17s18 H 305 C.s17s18.21
Van-der-waals C-term Y 346 - s17s18 H 305 C.s17s18.21
Hydrophobic C-term L 344 - S10 L 177 N.S10.05
Polar ICL2 A 155 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 A 155 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 A 155 34x54 s8s9 K 145 N.s8s9.09
Polar C-term K 354 - s20c G 391 C.s20c.10
Hydrophobic C-term K 354 - s20c G 391 C.s20c.10
Van-der-waals C-term K 354 - s20c G 391 C.s20c.10
Polar ICL2 R 158 34x57 s5s6 Q 73 N.s5s6.02
Hydrophobic TM6 Q 249 6x25 s9s10 E 165 N.s9s10.07
Van-der-waals TM6 Q 249 6x25 s9s10 E 165 N.s9s10.07
Polar H8 S 315 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 S 315 8x47 s5s6 V 78 N.s5s6.07
Polar ICL2 L 152 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 L 152 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 L 152 34x51 S5 Y 71 N.S5.12
Polar H8 N 317 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 317 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 317 8x49 s5s6 D 77 N.s5s6.06
Polar H8 D 316 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 W 247 6x23 S6 R 84 N.S6.02
Van-der-waals TM6 W 247 6x23 S6 R 84 N.S6.02
Hydrophobic C-term Y 346 - s17s18 K 302 C.s17s18.18
Van-der-waals C-term Y 346 - s17s18 K 302 C.s17s18.18
Polar ICL2 P 151 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 151 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 151 34x50 S5 Y 71 N.S5.12
Polar H8 N 317 8x49 s5s6 E 74 N.s5s6.03
Van-der-waals H8 N 317 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic TM5 V 241 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 V 241 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 260 6x36 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 L 260 6x36 s5s6 I 79 N.s5s6.08
Hydrophobic C-term E 341 - s1s2 R 22 N.s1s2.02
Hydrophobic TM3 R 144 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 144 3x50 s5s6 I 79 N.s5s6.08
Polar C-term Y 347 - s17s18 K 304 C.s17s18.20
Hydrophobic C-term Y 347 - s17s18 K 304 C.s17s18.20
Van-der-waals C-term Y 347 - s17s18 K 304 C.s17s18.20
Polar TM3 R 144 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 R 144 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 R 144 3x50 s5s6 V 78 N.s5s6.07
Ionic H8 R 320 8x52 s5s6 D 77 N.s5s6.06
Polar H8 R 320 8x52 s5s6 D 77 N.s5s6.06
Hydrophobic TM2 L 86 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 A 245 - S6 R 85 N.S6.03
Van-der-waals ICL3 A 245 - S6 R 85 N.S6.03
Hydrophobic TM6 W 247 6x23 S6 R 85 N.S6.03
Van-der-waals TM6 W 247 6x23 S6 R 85 N.S6.03
Polar ICL2 L 152 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 152 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 L 152 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 L 152 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 L 152 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 L 152 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 L 152 34x51 S15 V 251 C.S15.14
Polar ICL2 R 158 34x57 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 R 158 34x57 s8s9 K 145 N.s8s9.09
Polar TM6 R 250 6x26 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 R 250 6x26 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 M 238 5x65 s5s6 L 81 N.s5s6.10
Van-der-waals TM5 M 238 5x65 s5s6 L 81 N.s5s6.10
Ionic C-term E 342 - s1s2 R 22 N.s1s2.02
Polar C-term E 342 - s1s2 R 22 N.s1s2.02
Hydrophobic C-term E 342 - s1s2 R 22 N.s1s2.02
Van-der-waals C-term E 342 - s1s2 R 22 N.s1s2.02
Hydrophobic TM2 T 82 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 T 82 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 V 148 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 V 148 3x54 S6 F 83 N.S6.01
Polar H8 S 315 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 S 315 8x47 s5s6 D 77 N.s5s6.06
Polar ICL2 R 153 34x52 S16 Y 259 C.S16.03
Polar TM6 Q 249 6x25 s9s10 A 163 N.s9s10.05
Van-der-waals TM6 Q 249 6x25 s9s10 A 163 N.s9s10.05
Hydrophobic ICL2 L 152 34x51 S9 C 147 N.S9.01
Hydrophobic C-term A 339 - s9s10 K 171 N.s9s10.13
Polar ICL3 R 244 - S6 R 85 N.S6.03
Hydrophobic ICL3 R 244 - S6 R 85 N.S6.03
Van-der-waals ICL3 R 244 - S6 R 85 N.S6.03
Hydrophobic C-term A 348 - s8s9 S 143 N.s8s9.07
Hydrophobic TM6 I 257 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 I 257 6x33 s5s6 L 81 N.s5s6.10
Polar C-term K 354 - s20c A 390 C.s20c.09
Polar TM2 T 82 2x39 s5s6 D 75 N.s5s6.04
Hydrophobic C-term L 351 - s20c D 389 C.s20c.08
Van-der-waals C-term L 351 - s20c D 389 C.s20c.08
Hydrophobic C-term Y 346 - s17s18 K 304 C.s17s18.20
Van-der-waals C-term Y 346 - s17s18 K 304 C.s17s18.20
Polar TM6 W 247 6x23 S6 D 86 N.S6.04
Hydrophobic TM6 W 247 6x23 S6 D 86 N.S6.04
Van-der-waals TM6 W 247 6x23 S6 D 86 N.S6.04
Hydrophobic C-term Y 346 - S10 L 177 N.S10.05
Van-der-waals C-term Y 346 - S10 L 177 N.S10.05
Polar C-term D 345 - s17s18 K 304 C.s17s18.20
Hydrophobic C-term D 345 - s17s18 K 304 C.s17s18.20
Van-der-waals C-term D 345 - s17s18 K 304 C.s17s18.20
Polar TM5 K 237 5x64 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 K 237 5x64 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 K 237 5x64 s15s16 Y 254 C.s15s16.03
Ionic ICL2 R 153 34x52 S16 D 257 C.S16.01
Polar ICL2 R 153 34x52 S16 D 257 C.S16.01
Hydrophobic TM2 T 80 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 T 80 2x37 s5s6 D 75 N.s5s6.04
Ionic TM6 R 252 6x28 s9s10 E 164 N.s9s10.06
Polar TM6 R 252 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 R 252 6x28 s9s10 E 164 N.s9s10.06
Van-der-waals TM6 R 252 6x28 s9s10 E 164 N.s9s10.06
Hydrophobic ICL2 L 152 34x51 S8 L 136 N.S8.03
Van-der-waals ICL2 L 152 34x51 S8 L 136 N.S8.03
Hydrophobic TM6 I 257 6x33 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 I 257 6x33 s5s6 I 79 N.s5s6.08
Ionic C-term E 341 - s9s10 K 170 N.s9s10.12
Polar C-term E 341 - s9s10 K 170 N.s9s10.12
Van-der-waals C-term E 341 - s9s10 K 170 N.s9s10.12
Van-der-waals ICL2 L 152 34x51 s15s16 S 255 C.s15s16.04
Hydrophobic TM5 M 238 5x65 S6 F 83 N.S6.01
Polar TM6 R 250 6x26 S6 R 84 N.S6.02
Hydrophobic TM6 R 250 6x26 S6 R 84 N.S6.02
Van-der-waals TM6 R 250 6x26 S6 R 84 N.S6.02