Arrestin-C - SST5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
SST5 73.5
Arrestin-C 80.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 17.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL2 S 146 34x52 S16 Y 246 C.S16.03
Hydrophobic ICL2 S 146 34x52 S16 Y 246 C.S16.03
Van-der-waals ICL2 S 146 34x52 S16 Y 246 C.S16.03
Ionic ICL1 K 70 12x49 s20c E 383 C.s20c.17
Polar ICL1 K 70 12x49 s20c E 383 C.s20c.17
Hydrophobic ICL1 K 70 12x49 s20c E 383 C.s20c.17
Van-der-waals ICL1 K 70 12x49 s20c E 383 C.s20c.17
Hydrophobic TM5 R 234 5x71 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 R 234 5x71 s15s16 L 243 C.s15s16.05
Hydrophobic TM3 V 141 3x54 s5s6 I 67 N.s5s6.08
Hydrophobic TM5 I 224 5x61 s5s6 I 67 N.s5s6.08
Hydrophobic ICL2 P 144 34x50 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 V 228 5x65 S6 F 71 N.S6.01
Polar TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 R 137 3x50 s5s6 V 66 N.s5s6.07
Ionic TM3 H 143 3x56 S16 D 244 C.S16.01
Polar ICL2 L 145 34x51 S5 Y 59 N.S5.12
Hydrophobic ICL2 L 145 34x51 S5 Y 59 N.S5.12
Van-der-waals ICL2 L 145 34x51 S5 Y 59 N.S5.12
Hydrophobic TM5 A 231 5x68 S6 F 71 N.S6.01
Hydrophobic TM5 V 228 5x65 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 A 231 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 A 231 5x68 s15s16 Y 241 C.s15s16.03
Polar ICL2 L 145 34x51 S16 D 244 C.S16.01
Hydrophobic ICL2 L 145 34x51 S16 D 244 C.S16.01
Hydrophobic TM6 V 246 6x33 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 V 246 6x33 s5s6 L 69 N.s5s6.10
Polar TM5 V 235 5x72 S6 K 73 N.S6.03
Hydrophobic TM5 V 235 5x72 S6 K 73 N.S6.03
Van-der-waals TM5 V 235 5x72 S6 K 73 N.S6.03
Hydrophobic TM6 M 249 6x36 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 M 249 6x36 s5s6 I 67 N.s5s6.08
Polar ICL2 L 145 34x51 S16 Y 246 C.S16.03
Hydrophobic ICL2 L 145 34x51 S16 Y 246 C.S16.03
Van-der-waals ICL2 L 145 34x51 S16 Y 246 C.S16.03
Ionic H8 K 317 8x56 s20c E 383 C.s20c.17
Polar H8 K 317 8x56 s20c E 383 C.s20c.17
Van-der-waals H8 K 317 8x56 s20c E 383 C.s20c.17
Hydrophobic TM3 A 140 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 V 246 6x33 s5s6 I 67 N.s5s6.08
Polar ICL2 P 144 34x50 S16 D 244 C.S16.01
Hydrophobic ICL2 P 144 34x50 S16 D 244 C.S16.01
Van-der-waals ICL2 P 144 34x50 S16 D 244 C.S16.01
Polar TM5 R 234 5x71 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 R 234 5x71 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 R 234 5x71 s15s16 Y 241 C.s15s16.03
Ionic ICL2 R 151 34x57 s5s6 D 63 N.s5s6.04
Polar ICL2 R 151 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic ICL2 R 151 34x57 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 R 151 34x57 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 V 141 3x54 s5s6 L 64 N.s5s6.05
Van-der-waals TM3 V 141 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 V 235 5x72 s15s16 L 240 C.s15s16.02
Van-der-waals TM5 V 235 5x72 s15s16 L 240 C.s15s16.02
Hydrophobic TM3 A 140 3x53 s5s6 L 64 N.s5s6.05
Hydrophobic TM4 P 153 4x39 s8s9 E 131 N.s8s9.05
Van-der-waals TM4 P 153 4x39 s8s9 E 131 N.s8s9.05
Polar H8 N 310 8x49 s5s6 E 65 N.s5s6.06
Hydrophobic H8 N 310 8x49 s5s6 E 65 N.s5s6.06
Van-der-waals H8 N 310 8x49 s5s6 E 65 N.s5s6.06
Ionic ICL2 R 151 34x57 s8s9 D 132 N.s8s9.06
Hydrophobic H8 S 308 8x47 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 L 145 34x51 S8 L 126 N.S8.03
Van-der-waals ICL2 L 145 34x51 S8 L 126 N.S8.03
Hydrophobic ICL2 A 148 34x54 s5s6 R 61 N.s5s6.02
Hydrophobic TM3 R 137 3x50 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 R 137 3x50 s5s6 I 67 N.s5s6.08
Polar TM2 T 75 2x39 s5s6 D 63 N.s5s6.04
Van-der-waals TM2 T 75 2x39 s5s6 D 63 N.s5s6.04
Polar TM5 K 227 5x64 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 K 227 5x64 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 K 227 5x64 s15s16 S 242 C.s15s16.04
Hydrophobic ICL2 L 145 34x51 S9 C 137 N.S9.01
Polar TM5 R 234 5x71 s15s16 V 239 C.s15s16.01
Hydrophobic ICL2 P 144 34x50 s15s16 S 242 C.s15s16.04
Van-der-waals ICL2 P 144 34x50 s15s16 S 242 C.s15s16.04
Polar ICL2 P 144 34x50 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 P 144 34x50 s5s6 R 61 N.s5s6.02
Van-der-waals ICL2 P 144 34x50 s5s6 R 61 N.s5s6.02
Polar TM5 K 227 5x64 s15s16 Y 241 C.s15s16.03
Aromatic TM5 K 227 5x64 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 K 227 5x64 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 K 227 5x64 s15s16 Y 241 C.s15s16.03
Polar TM5 R 234 5x71 S6 K 73 N.S6.03
Van-der-waals TM5 R 234 5x71 S6 K 73 N.S6.03
Hydrophobic TM5 R 234 5x71 s17s18 E 310 C.s17s18.39
Polar ICL2 P 144 34x50 S5 Y 59 N.S5.12
Hydrophobic ICL2 P 144 34x50 S5 Y 59 N.S5.12
Van-der-waals ICL2 P 144 34x50 S5 Y 59 N.S5.12
Polar TM3 V 141 3x54 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 V 141 3x54 s15s16 Y 241 C.s15s16.03
Van-der-waals TM3 V 141 3x54 s15s16 Y 241 C.s15s16.03
Hydrophobic ICL3 V 238 - S6 F 71 N.S6.01
Hydrophobic TM2 T 75 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 V 141 3x54 s5s6 L 69 N.s5s6.10
Hydrophobic ICL2 L 145 34x51 s5s6 R 61 N.s5s6.02
Hydrophobic ICL2 L 145 34x51 S15 V 238 C.S15.14
Van-der-waals ICL2 L 145 34x51 S15 V 238 C.S15.14