Beta-arrestin-1 - succinate receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
succinate 83.7
Beta-arrestin-1 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 18.1


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 233 6x36 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 K 229 6x32 s5s6 G 72 N.s5s6.09
Van-der-waals TM6 K 229 6x32 s5s6 G 72 N.s5s6.09
Hydrophobic TM6 P 230 6x33 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 P 230 6x33 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 F 128 34x51 S9 C 140 N.S9.01
Hydrophobic ICL2 R 129 34x52 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 R 129 34x52 s5s6 R 65 N.s5s6.02
Polar TM5 Q 220 5x71 S6 K 77 N.S6.03
Ionic ICL2 R 129 34x52 s5s6 D 67 N.s5s6.04
Polar ICL2 R 129 34x52 s5s6 D 67 N.s5s6.04
Van-der-waals ICL2 R 129 34x52 s5s6 D 67 N.s5s6.04
Hydrophobic TM5 F 213 5x64 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 F 128 34x51 s8s9 A 139 N.s8s9.10
Van-der-waals ICL2 F 128 34x51 s8s9 A 139 N.s8s9.10
Hydrophobic TM5 L 214 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 V 221 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 V 221 5x72 s15s16 F 244 C.s15s16.03
Polar TM3 K 125 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 K 125 3x55 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 K 125 3x55 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 214 5x65 S6 F 75 N.S6.01
Van-der-waals TM5 L 214 5x65 S6 F 75 N.S6.01
Van-der-waals H8 G 299 8x47 s5s6 E 66 N.s5s6.03
Polar TM2 N 56 2x37 s5s6 D 67 N.s5s6.04
Polar TM3 I 124 3x54 S5 Y 63 N.S5.12
Van-der-waals TM3 I 124 3x54 S5 Y 63 N.S5.12
Hydrophobic ICL2 F 128 34x51 s8s9 Q 130 N.s8s9.01
Van-der-waals ICL2 F 128 34x51 s8s9 Q 130 N.s8s9.01
Aromatic TM5 R 217 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 R 217 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 R 217 5x68 s15s16 F 244 C.s15s16.03
Ionic ICL1 K 53 - s20c D 402 C.s20c.12
Polar ICL1 K 53 - s20c D 402 C.s20c.12
Van-der-waals ICL1 K 53 - s20c D 402 C.s20c.12
Hydrophobic ICL2 F 128 34x51 s8s9 P 131 N.s8s9.02
Hydrophobic TM6 K 229 6x32 s5s6 V 70 N.s5s6.07
Van-der-waals TM6 K 229 6x32 s5s6 V 70 N.s5s6.07
Polar TM6 P 230 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 P 230 6x33 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 P 230 6x33 s5s6 L 71 N.s5s6.08
Hydrophobic ICL2 F 128 34x51 S8 L 129 N.S8.03
Van-der-waals ICL2 F 128 34x51 S8 L 129 N.S8.03
Hydrophobic TM3 I 124 3x54 S6 F 75 N.S6.01
Hydrophobic ICL2 E 130 34x53 S16 Y 249 C.S16.03
Van-der-waals ICL2 E 130 34x53 S16 Y 249 C.S16.03
Hydrophobic TM3 I 123 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 123 3x53 s5s6 L 68 N.s5s6.05
Polar ICL2 P 127 34x50 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 P 127 34x50 s5s6 R 65 N.s5s6.02
Polar ICL3 T 223 - S6 D 78 N.S6.04
Hydrophobic ICL3 T 223 - S6 D 78 N.S6.04
Van-der-waals ICL3 T 223 - S6 D 78 N.S6.04
Hydrophobic TM3 I 124 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 124 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 R 120 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 F 213 5x64 S6 F 75 N.S6.01
Hydrophobic TM5 V 221 5x72 S6 R 76 N.S6.02
Van-der-waals TM5 V 221 5x72 S6 R 76 N.S6.02
Ionic TM6 K 229 6x32 s5s6 D 69 N.s5s6.06
Polar TM6 K 229 6x32 s5s6 D 69 N.s5s6.06
Van-der-waals TM6 K 229 6x32 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 K 229 6x32 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 K 229 6x32 s5s6 L 71 N.s5s6.08
Ionic H8 H 301 8x49 s5s6 D 69 N.s5s6.06
Polar TM5 R 217 5x68 S6 F 75 N.S6.01
Aromatic TM5 R 217 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 R 217 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 R 217 5x68 S6 F 75 N.S6.01
Polar TM3 I 124 3x54 s15s16 N 245 C.s15s16.04
Van-der-waals TM3 I 124 3x54 s15s16 N 245 C.s15s16.04
Hydrophobic TM7 L 298 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 298 7x56 s5s6 V 70 N.s5s6.07
Polar TM3 R 120 3x50 s5s6 D 67 N.s5s6.04
Polar ICL1 N 54 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 N 54 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 N 54 - s8s9 E 134 N.s8s9.05
Hydrophobic TM6 L 227 6x30 S6 F 75 N.S6.01
Van-der-waals TM6 L 227 6x30 S6 F 75 N.S6.01
Aromatic ICL2 F 128 34x51 S16 Y 249 C.S16.03
Hydrophobic ICL2 F 128 34x51 S16 Y 249 C.S16.03
Van-der-waals ICL2 F 128 34x51 S16 Y 249 C.S16.03
Hydrophobic TM6 L 227 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 L 227 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 R 120 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 R 120 3x50 s5s6 L 71 N.s5s6.08
Polar ICL2 F 128 34x51 s5s6 R 65 N.s5s6.02
Aromatic ICL2 F 128 34x51 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 F 128 34x51 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 V 221 5x72 S6 K 77 N.S6.03
Van-der-waals TM5 V 221 5x72 S6 K 77 N.S6.03
Hydrophobic H8 G 299 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 G 299 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 P 127 34x50 S5 Y 63 N.S5.12
Van-der-waals ICL2 P 127 34x50 S5 Y 63 N.S5.12
Hydrophobic ICL2 F 128 34x51 s17s18 G 286 C.s17s18.12
Hydrophobic TM5 R 217 5x68 S5 Y 63 N.S5.12
Van-der-waals TM5 R 217 5x68 S5 Y 63 N.S5.12
Hydrophobic TM7 F 296 7x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 F 296 7x54 s5s6 V 70 N.s5s6.07
Hydrophobic H8 G 299 8x47 s5s6 D 67 N.s5s6.04
Hydrophobic TM7 L 297 7x55 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 L 297 7x55 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 F 128 34x51 S15 I 241 C.S15.14