S-arrestin - succinate receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
succinate 82.6
S-arrestin 78.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 227 6x30 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 227 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 K 229 6x32 s5s6 L 81 N.s5s6.10
Hydrophobic H8 G 299 8x47 s5s6 I 79 N.s5s6.08
Van-der-waals H8 G 299 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 K 229 6x32 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 K 229 6x32 s5s6 I 79 N.s5s6.08
Polar H8 D 300 8x48 s5s6 D 75 N.s5s6.04
Van-der-waals H8 D 300 8x48 s5s6 D 75 N.s5s6.04
Van-der-waals TM7 F 296 7x54 s5s6 V 78 N.s5s6.07
Hydrophobic ICL3 T 223 - S6 D 86 N.S6.04
Hydrophobic TM3 I 123 3x53 S6 F 83 N.S6.01
Hydrophobic TM7 L 297 7x55 s5s6 V 78 N.s5s6.07
Van-der-waals TM7 L 297 7x55 s5s6 V 78 N.s5s6.07
Hydrophobic TM5 R 217 5x68 S6 R 85 N.S6.03
Van-der-waals TM5 R 217 5x68 S6 R 85 N.S6.03
Polar ICL2 F 128 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 128 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 F 128 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 128 34x51 S15 V 251 C.S15.14
Van-der-waals ICL2 F 128 34x51 S15 V 251 C.S15.14
Hydrophobic ICL2 E 130 34x53 S16 D 257 C.S16.01
Van-der-waals ICL2 E 130 34x53 S16 D 257 C.S16.01
Hydrophobic ICL2 F 128 34x51 S8 L 136 N.S8.03
Aromatic ICL2 F 128 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL2 F 128 34x51 S16 Y 259 C.S16.03
Van-der-waals ICL2 F 128 34x51 S16 Y 259 C.S16.03
Hydrophobic ICL3 T 223 - S6 F 89 N.S6.07
Hydrophobic ICL3 L 225 - S6 R 84 N.S6.02
Hydrophobic TM6 P 230 6x33 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 P 230 6x33 s5s6 L 81 N.s5s6.10
Polar ICL2 P 127 34x50 S5 Y 71 N.S5.12
Hydrophobic ICL2 P 127 34x50 S5 Y 71 N.S5.12
Van-der-waals ICL2 P 127 34x50 S5 Y 71 N.S5.12
Polar ICL2 F 128 34x51 S16 D 257 C.S16.01
Hydrophobic ICL2 F 128 34x51 S16 D 257 C.S16.01
Van-der-waals ICL2 F 128 34x51 S16 D 257 C.S16.01
Polar TM7 L 298 7x56 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 L 298 7x56 s5s6 V 78 N.s5s6.07
Polar TM5 R 217 5x68 s15s16 L 253 C.s15s16.02
Hydrophobic TM6 P 230 6x33 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 P 127 34x50 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 P 127 34x50 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 R 129 34x52 s8s9 K 145 N.s8s9.09
Polar TM6 K 229 6x32 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 K 229 6x32 s5s6 G 80 N.s5s6.09
Van-der-waals TM6 K 229 6x32 s5s6 G 80 N.s5s6.09
Polar TM7 L 297 7x55 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 L 297 7x55 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 L 297 7x55 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 L 227 6x30 S6 F 83 N.S6.01
Van-der-waals TM6 L 227 6x30 S6 F 83 N.S6.01
Hydrophobic TM7 L 298 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 L 298 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 V 221 5x72 S6 D 86 N.S6.04
Van-der-waals TM5 V 221 5x72 S6 D 86 N.S6.04
Hydrophobic TM3 I 124 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 124 3x54 S6 F 83 N.S6.01
Ionic TM6 K 229 6x32 s5s6 D 77 N.s5s6.06
Hydrophobic H8 D 300 8x48 s5s6 V 78 N.s5s6.07
Van-der-waals H8 D 300 8x48 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 K 125 3x55 s15s16 Y 254 C.s15s16.03
Hydrophobic H8 H 301 8x49 s5s6 V 78 N.s5s6.07
Van-der-waals H8 H 301 8x49 s5s6 V 78 N.s5s6.07
Hydrophobic ICL2 F 128 34x51 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 F 128 34x51 s15s16 S 255 C.s15s16.04
Polar H8 H 301 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic H8 H 301 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 H 301 8x49 s5s6 D 75 N.s5s6.04
Hydrophobic ICL3 L 225 - s9s10 E 165 N.s9s10.07
Van-der-waals ICL3 L 225 - s9s10 E 165 N.s9s10.07
Hydrophobic TM5 V 221 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 V 221 5x72 S6 R 85 N.S6.03
Polar TM5 R 217 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 R 217 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 R 217 5x68 s15s16 Y 254 C.s15s16.03
Polar H8 H 301 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic H8 H 301 8x49 s5s6 E 74 N.s5s6.03
Hydrophobic ICL2 F 128 34x51 S9 C 147 N.S9.01
Van-der-waals ICL2 F 128 34x51 S9 C 147 N.S9.01
Polar H8 G 299 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 G 299 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 G 299 8x47 s5s6 V 78 N.s5s6.07
Polar ICL1 N 54 - s8s9 Q 141 N.s8s9.05
Hydrophobic ICL1 N 54 - s8s9 Q 141 N.s8s9.05
Van-der-waals ICL1 N 54 - s8s9 Q 141 N.s8s9.05
Polar ICL1 N 54 - s8s9 P 140 N.s8s9.04
Polar TM5 Q 220 5x71 S6 R 85 N.S6.03
Van-der-waals H8 G 299 8x47 s5s6 D 75 N.s5s6.04
Ionic H8 H 301 8x49 s5s6 D 77 N.s5s6.06
Polar H8 H 301 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic H8 H 301 8x49 s5s6 D 77 N.s5s6.06
Van-der-waals H8 H 301 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 R 120 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 R 120 3x50 s5s6 I 79 N.s5s6.08
Hydrophobic TM3 Y 126 3x56 s15s16 S 255 C.s15s16.04
Polar ICL2 E 130 34x53 S16 Y 258 C.S16.02
Van-der-waals ICL2 E 130 34x53 S16 Y 258 C.S16.02
Hydrophobic ICL2 P 127 34x50 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 P 127 34x50 s15s16 Y 254 C.s15s16.03
Polar ICL2 F 128 34x51 S5 Y 71 N.S5.12
Aromatic ICL2 F 128 34x51 S5 Y 71 N.S5.12
Hydrophobic ICL2 F 128 34x51 S5 Y 71 N.S5.12
Van-der-waals ICL2 F 128 34x51 S5 Y 71 N.S5.12
Polar H8 G 299 8x47 s5s6 I 76 N.s5s6.05
Hydrophobic H8 G 299 8x47 s5s6 I 76 N.s5s6.05
Van-der-waals H8 G 299 8x47 s5s6 I 76 N.s5s6.05