Beta-arrestin-2 - TAS2R10 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
TAS2R10 82.6
Beta-arrestin-2 79.5
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 V 211 5x76 S6 K 78 N.S6.03
Van-der-waals TM5 V 211 5x76 S6 K 78 N.S6.03
Hydrophobic TM2 I 43 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 I 43 2x39 s5s6 V 71 N.s5s6.07
Polar TM6 S 217 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 S 217 6x26 S6 R 77 N.S6.02
Van-der-waals TM6 S 217 6x26 S6 R 77 N.S6.02
Hydrophobic TM6 V 228 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 228 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 L 229 6x38 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 S 41 2x37 s8s9 T 137 N.s8s9.07
Polar ICL2 K 122 34x54 s15s16 T 247 C.s15s16.05
Hydrophobic TM6 H 222 6x31 s5s6 L 74 N.s5s6.10
Polar TM6 N 218 6x27 S6 R 77 N.S6.02
Ionic H8 K 283 8x49 s5s6 E 67 N.s5s6.03
Polar H8 K 283 8x49 s5s6 E 67 N.s5s6.03
Hydrophobic H8 K 283 8x49 s5s6 E 67 N.s5s6.03
Van-der-waals H8 K 283 8x49 s5s6 E 67 N.s5s6.03
Aromatic TM6 H 222 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 H 222 6x31 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 H 222 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 Y 106 3x50 s5s6 L 72 N.s5s6.08
Polar H8 N 281 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic H8 N 281 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 281 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 K 109 3x53 s5s6 L 69 N.s5s6.05
Polar ICL2 K 122 34x54 s15s16 S 246 C.s15s16.04
Hydrophobic ICL3 L 214 - S6 I 82 N.S6.07
Van-der-waals ICL3 L 214 - S6 I 82 N.S6.07
Ionic TM6 D 216 6x25 S6 K 78 N.S6.03
Polar TM6 D 216 6x25 S6 K 78 N.S6.03
Hydrophobic TM6 D 216 6x25 S6 K 78 N.S6.03
Van-der-waals TM6 D 216 6x25 S6 K 78 N.S6.03
Hydrophobic TM7 G 280 7x56 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 G 280 7x56 s5s6 L 72 N.s5s6.08
Polar TM4 N 126 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM4 N 126 4x39 s8s9 E 135 N.s8s9.05
Van-der-waals TM4 N 126 4x39 s8s9 E 135 N.s8s9.05
Hydrophobic TM5 L 196 5x61 s5s6 L 72 N.s5s6.08
Polar TM5 Q 206 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 Q 206 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 Q 206 5x71 s17s18 E 314 C.s17s18.39
Polar H8 S 282 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 S 282 8x48 s5s6 D 70 N.s5s6.06
Van-der-waals H8 S 282 8x48 s5s6 D 70 N.s5s6.06
Hydrophobic H8 N 281 8x47 s5s6 D 70 N.s5s6.06
Van-der-waals H8 N 281 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic TM6 F 232 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 M 207 5x72 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 M 207 5x72 s17s18 E 314 C.s17s18.39
Hydrophobic TM3 I 110 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 110 3x54 s5s6 L 72 N.s5s6.08
Polar TM5 H 203 5x68 s15s16 L 244 C.s15s16.02
Hydrophobic TM5 H 203 5x68 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 H 203 5x68 s15s16 L 244 C.s15s16.02
Hydrophobic TM3 F 105 3x49 s5s6 D 68 N.s5s6.04
Polar TM5 N 210 5x75 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 N 210 5x75 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 N 210 5x75 s17s18 N 312 C.s17s18.37
Hydrophobic TM3 Y 106 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 Y 106 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 221 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 221 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM7 G 280 7x56 s5s6 V 71 N.s5s6.07
Polar TM3 K 109 3x53 s15s16 S 246 C.s15s16.04
Hydrophobic TM5 M 207 5x72 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 M 207 5x72 s15s16 L 244 C.s15s16.02
Ionic TM3 K 109 3x53 s5s6 D 68 N.s5s6.04
Polar TM3 K 109 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 K 109 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 109 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 A 225 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 225 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 110 3x54 s5s6 L 74 N.s5s6.10
Van-der-waals TM3 I 110 3x54 s5s6 L 74 N.s5s6.10
Polar TM5 H 203 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 203 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 203 5x68 s15s16 F 245 C.s15s16.03
Polar TM7 G 280 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic TM7 G 280 7x56 s5s6 G 73 N.s5s6.09
Van-der-waals TM7 G 280 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 N 218 6x27 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 N 218 6x27 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 N 218 6x27 S6 F 76 N.S6.01
Van-der-waals TM6 N 218 6x27 S6 F 76 N.S6.01
Hydrophobic TM6 A 225 6x34 s5s6 L 72 N.s5s6.08
Ionic TM3 K 109 3x53 s8s9 D 136 N.s8s9.06
Polar TM3 K 109 3x53 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 S 217 6x26 S6 F 76 N.S6.01
Hydrophobic TM3 I 110 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 110 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM2 I 43 2x39 s5s6 D 68 N.s5s6.04
Polar TM5 N 210 5x75 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 N 210 5x75 s17s18 E 314 C.s17s18.39
Polar ICL2 N 112 34x44 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 N 112 34x44 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 N 112 34x44 s15s16 T 247 C.s15s16.05
Polar TM6 N 218 6x27 s15s16 L 244 C.s15s16.02
Hydrophobic TM2 L 47 2x43 s5s6 V 71 N.s5s6.07