Beta-arrestin-1 - TAS2R16 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
TAS2R16 77.6
Beta-arrestin-1 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL1 R 41 - s8s9 D 135 N.s8s9.06
Hydrophobic ICL1 R 41 - s8s9 D 135 N.s8s9.06
Van-der-waals ICL1 R 41 - s8s9 D 135 N.s8s9.06
Ionic TM5 H 214 5x76 s9s10 E 155 N.s9s10.07
Polar TM5 H 214 5x76 s9s10 E 155 N.s9s10.07
Hydrophobic TM5 H 214 5x76 s9s10 E 155 N.s9s10.07
Van-der-waals TM5 H 214 5x76 s9s10 E 155 N.s9s10.07
Hydrophobic TM6 R 222 6x31 s5s6 L 73 N.s5s6.10
Polar H8 P 281 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 P 281 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 P 281 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM6 A 225 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 225 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 S 228 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 228 6x37 s5s6 L 71 N.s5s6.08
Polar H8 T 282 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 T 282 8x49 s5s6 D 69 N.s5s6.06
Hydrophobic TM2 M 43 2x37 s5s6 E 66 N.s5s6.03
Hydrophobic TM3 Y 103 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 221 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 221 6x30 s5s6 L 73 N.s5s6.10
Polar ICL2 R 119 34x54 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 R 119 34x54 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 R 119 34x54 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 Y 103 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 Y 103 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic ICL2 W 120 34x55 S16 A 247 C.S16.01
Van-der-waals ICL2 W 120 34x55 S16 A 247 C.S16.01
Hydrophobic TM3 V 107 3x54 s15s16 F 244 C.s15s16.03
Polar TM7 S 279 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 S 279 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals ICL2 L 116 34x51 s15s16 T 246 C.s15s16.05
Hydrophobic H8 P 281 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 V 107 3x54 s5s6 L 73 N.s5s6.10
Ionic H8 R 285 8x52 s5s6 E 66 N.s5s6.03
Polar H8 R 285 8x52 s5s6 E 66 N.s5s6.03
Hydrophobic TM4 L 123 4x39 s8s9 T 136 N.s8s9.07
Van-der-waals TM4 L 123 4x39 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 R 41 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 R 41 - s8s9 T 136 N.s8s9.07
Van-der-waals ICL1 R 41 - s5s6 R 65 N.s5s6.02
Hydrophobic TM3 V 107 3x54 s5s6 L 68 N.s5s6.05
Hydrophobic ICL2 W 120 34x55 S16 Q 248 C.S16.02
Van-der-waals ICL2 W 120 34x55 S16 Q 248 C.S16.02
Hydrophobic TM3 V 107 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 A 225 6x34 s5s6 L 71 N.s5s6.08
Polar ICL1 R 41 - s8s9 E 134 N.s8s9.05
Hydrophobic ICL1 R 41 - s8s9 E 134 N.s8s9.05
Van-der-waals ICL1 R 41 - s8s9 E 134 N.s8s9.05
Polar ICL1 R 41 - s8s9 G 132 N.s8s9.03
Van-der-waals ICL1 R 41 - s8s9 G 132 N.s8s9.03
Hydrophobic TM5 L 203 5x65 s5s6 L 73 N.s5s6.10
Hydrophobic TM3 F 102 3x49 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 L 229 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 229 6x38 s5s6 L 71 N.s5s6.08
Ionic H8 R 285 8x52 s20c E 405 C.s20c.15
Polar H8 R 285 8x52 s20c E 405 C.s20c.15
Hydrophobic H8 R 285 8x52 s20c E 405 C.s20c.15
Van-der-waals H8 R 285 8x52 s20c E 405 C.s20c.15
Hydrophobic TM2 V 45 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 V 45 2x39 s5s6 V 70 N.s5s6.07
Polar ICL2 W 120 34x55 s15s16 N 245 C.s15s16.04
Polar TM7 S 279 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 S 279 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 S 279 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 K 106 3x53 s15s16 F 244 C.s15s16.03
Van-der-waals TM3 K 106 3x53 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 W 120 34x55 S16 Y 249 C.S16.03
Hydrophobic TM2 M 43 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 M 43 2x37 s5s6 D 67 N.s5s6.04
Polar ICL2 W 120 34x55 s15s16 T 246 C.s15s16.05
Hydrophobic ICL2 W 120 34x55 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 W 120 34x55 s15s16 T 246 C.s15s16.05
Polar ICL1 R 41 - s8s9 P 133 N.s8s9.04
Hydrophobic ICL1 R 41 - s8s9 P 133 N.s8s9.04
Van-der-waals ICL1 R 41 - s8s9 P 133 N.s8s9.04
Polar ICL2 R 119 34x54 s15s16 F 244 C.s15s16.03
Aromatic ICL2 R 119 34x54 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 R 119 34x54 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 R 119 34x54 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 M 43 2x37 s5s6 R 65 N.s5s6.02