Beta-arrestin-2 - TAS2R20 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
TAS2R20 81.8
Beta-arrestin-2 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 18.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL3 K 214 - S6 D 79 N.S6.04
Hydrophobic ICL3 K 214 - S6 D 79 N.S6.04
Van-der-waals ICL3 K 214 - S6 D 79 N.S6.04
Hydrophobic TM3 Y 106 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 L 198 5x61 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 S 42 2x37 s5s6 E 67 N.s5s6.03
Van-der-waals TM2 S 42 2x37 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 S 220 6x27 S6 K 78 N.S6.03
Hydrophobic TM6 A 227 6x34 s5s6 L 72 N.s5s6.08
Polar ICL2 K 122 34x54 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 A 44 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 A 44 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 I 223 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 I 223 6x30 s5s6 L 74 N.s5s6.10
Polar ICL2 N 112 34x44 s15s16 S 246 C.s15s16.04
Hydrophobic ICL2 N 112 34x44 s15s16 S 246 C.s15s16.04
Van-der-waals ICL2 N 112 34x44 s15s16 S 246 C.s15s16.04
Polar TM4 K 126 4x39 s8s9 E 135 N.s8s9.05
Polar TM5 H 205 5x68 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 H 205 5x68 s15s16 L 244 C.s15s16.02
Aromatic TM5 H 205 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 205 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 A 227 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 227 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 I 223 6x30 S6 F 76 N.S6.01
Aromatic TM6 H 224 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 H 224 6x31 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 H 224 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 V 231 6x38 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 V 231 6x38 s5s6 L 72 N.s5s6.08
Polar TM7 G 282 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic TM7 G 282 7x56 s5s6 G 73 N.s5s6.09
Van-der-waals TM7 G 282 7x56 s5s6 G 73 N.s5s6.09
Ionic TM5 H 212 5x75 s17s18 E 314 C.s17s18.39
Hydrophobic TM3 I 110 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 110 3x54 s5s6 L 72 N.s5s6.08
Polar ICL2 N 112 34x44 s15s16 F 245 C.s15s16.03
Van-der-waals ICL2 N 112 34x44 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 205 5x68 S6 F 76 N.S6.01
Polar TM3 Y 106 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 Y 106 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 Y 106 3x50 s5s6 V 71 N.s5s6.07
Ionic TM5 K 208 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 208 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic TM5 K 208 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 208 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 K 214 - S6 K 78 N.S6.03
Van-der-waals ICL3 K 214 - S6 K 78 N.S6.03
Polar TM6 D 218 6x25 S6 D 79 N.S6.04
Hydrophobic TM6 S 220 6x27 S6 F 76 N.S6.01
Van-der-waals TM6 S 220 6x27 S6 F 76 N.S6.01
Hydrophobic TM5 L 202 5x65 s15s16 F 245 C.s15s16.03
Ionic TM3 K 109 3x53 s5s6 D 68 N.s5s6.04
Polar TM3 K 109 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 K 109 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 109 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 110 3x54 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 M 209 5x72 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 M 209 5x72 s15s16 L 244 C.s15s16.02
Hydrophobic TM3 I 110 3x54 s15s16 F 245 C.s15s16.03
Van-der-waals TM3 I 110 3x54 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 M 209 5x72 S6 K 78 N.S6.03
Van-der-waals TM5 M 209 5x72 S6 K 78 N.S6.03
Polar TM5 H 212 5x75 s17s18 N 312 C.s17s18.37
Hydrophobic TM5 H 212 5x75 s17s18 N 312 C.s17s18.37
Van-der-waals TM5 H 212 5x75 s17s18 N 312 C.s17s18.37
Polar TM2 S 42 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 S 42 2x37 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 H 224 6x31 S6 F 76 N.S6.01
Van-der-waals TM6 H 224 6x31 S6 F 76 N.S6.01
Hydrophobic ICL3 K 214 - S6 L 80 N.S6.05
Van-der-waals ICL3 K 214 - S6 L 80 N.S6.05
Hydrophobic TM6 H 224 6x31 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 110 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic TM5 M 209 5x72 S6 F 76 N.S6.01
Hydrophobic TM6 I 223 6x30 s5s6 S 75 N.s5s6.11
Van-der-waals TM6 I 223 6x30 s5s6 S 75 N.s5s6.11
Hydrophobic TM6 T 230 6x37 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 T 230 6x37 s5s6 L 72 N.s5s6.08
Polar ICL2 N 112 34x44 s15s16 T 247 C.s15s16.05
Hydrophobic ICL2 N 112 34x44 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 N 112 34x44 s15s16 T 247 C.s15s16.05
Polar TM6 S 220 6x27 S6 R 77 N.S6.02
Van-der-waals TM6 S 220 6x27 S6 R 77 N.S6.02
Hydrophobic TM7 G 282 7x56 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 G 282 7x56 s5s6 L 72 N.s5s6.08