Beta-arrestin-2 - TAS2R30 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R30 79.4
Beta-arrestin-2 80.2
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 20.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 F 105 3x49 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 F 105 3x49 s5s6 V 71 N.s5s6.07
Polar TM6 H 224 6x31 s5s6 R 66 N.s5s6.02
Van-der-waals TM6 H 224 6x31 s5s6 R 66 N.s5s6.02
Ionic ICL2 K 122 34x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 Y 106 3x50 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 Y 106 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 F 234 6x41 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 227 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic H8 R 295 8x59 s9s10 K 158 N.s9s10.09
Van-der-waals H8 R 295 8x59 s9s10 K 158 N.s9s10.09
Hydrophobic TM2 V 44 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 V 44 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 V 223 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 H 224 6x31 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 R 109 3x53 s5s6 V 71 N.s5s6.07
Hydrophobic TM7 G 282 7x56 s5s6 L 74 N.s5s6.10
Van-der-waals TM7 G 282 7x56 s5s6 L 74 N.s5s6.10
Polar H8 K 284 8x48 s5s6 S 75 N.s5s6.11
Ionic ICL1 K 40 - s20c D 403 C.s20c.13
Polar ICL1 K 40 - s20c D 403 C.s20c.13
Hydrophobic ICL1 K 40 - s20c D 403 C.s20c.13
Van-der-waals ICL1 K 40 - s20c D 403 C.s20c.13
Polar H8 K 284 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic H8 K 284 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals H8 K 284 8x48 s5s6 G 73 N.s5s6.09
Polar TM3 R 109 3x53 s20c Y 404 C.s20c.14
Hydrophobic TM6 A 227 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 227 6x34 s5s6 L 74 N.s5s6.10
Ionic TM3 R 109 3x53 s5s6 E 67 N.s5s6.03
Polar TM3 R 109 3x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 R 109 3x53 s5s6 E 67 N.s5s6.03
Van-der-waals TM3 R 109 3x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 P 219 6x26 S6 K 78 N.S6.03
Hydrophobic TM6 V 223 6x30 S6 F 76 N.S6.01
Aromatic TM6 H 224 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 H 224 6x31 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 H 224 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 V 231 6x38 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 K 226 6x33 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 K 226 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 110 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 110 3x54 s5s6 L 72 N.s5s6.08
Polar TM6 S 220 6x27 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 S 220 6x27 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 S 220 6x27 s15s16 F 245 C.s15s16.03
Polar ICL3 K 214 - s15s16 F 245 C.s15s16.03
Hydrophobic ICL3 K 214 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 K 214 - s15s16 F 245 C.s15s16.03
Van-der-waals ICL3 K 214 - s15s16 L 244 C.s15s16.02
Polar TM3 Y 106 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 Y 106 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 Y 106 3x50 s5s6 V 71 N.s5s6.07
Polar H8 N 283 8x47 s5s6 L 72 N.s5s6.08
Hydrophobic H8 N 283 8x47 s5s6 L 72 N.s5s6.08
Van-der-waals H8 N 283 8x47 s5s6 L 72 N.s5s6.08
Polar TM3 I 110 3x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 I 110 3x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 I 110 3x54 s5s6 D 68 N.s5s6.04
Polar TM5 H 205 5x68 s5s6 R 66 N.s5s6.02
Aromatic TM5 H 205 5x68 s5s6 R 66 N.s5s6.02
Hydrophobic TM5 H 205 5x68 s5s6 R 66 N.s5s6.02
Van-der-waals TM5 H 205 5x68 s5s6 R 66 N.s5s6.02
Hydrophobic TM6 S 220 6x27 S6 F 76 N.S6.01
Van-der-waals TM6 S 220 6x27 S6 F 76 N.S6.01
Hydrophobic TM6 V 223 6x30 s5s6 L 69 N.s5s6.05
Van-der-waals TM6 V 223 6x30 s5s6 L 69 N.s5s6.05
Hydrophobic TM3 R 109 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 R 109 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic H8 H 296 8x60 s9s10 H 160 N.s9s10.11
Ionic ICL3 K 214 - s17s18 E 314 C.s17s18.39
Hydrophobic ICL3 K 214 - s17s18 E 314 C.s17s18.39
Van-der-waals ICL3 K 214 - s17s18 E 314 C.s17s18.39
Hydrophobic TM5 L 202 5x65 s5s6 L 69 N.s5s6.05
Hydrophobic TM6 A 227 6x34 s5s6 L 69 N.s5s6.05
Van-der-waals TM6 A 227 6x34 s5s6 L 69 N.s5s6.05
Polar TM1 R 38 1x64 s20c D 406 C.s20c.16
Hydrophobic TM6 V 223 6x30 s15s16 F 245 C.s15s16.03
Polar ICL1 K 40 - s20c D 401 C.s20c.11
Van-der-waals ICL1 K 40 - s20c D 401 C.s20c.11
Polar ICL2 N 112 34x44 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 N 112 34x44 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 P 219 6x26 S6 F 76 N.S6.01
Van-der-waals TM6 P 219 6x26 S6 F 76 N.S6.01
Hydrophobic TM3 I 110 3x54 s5s6 L 69 N.s5s6.05
Ionic ICL2 R 123 34x55 s8s9 E 135 N.s8s9.05
Polar ICL2 R 123 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 R 123 34x55 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 R 123 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 I 110 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 T 230 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic H8 N 283 8x47 s5s6 G 73 N.s5s6.09
Van-der-waals H8 N 283 8x47 s5s6 G 73 N.s5s6.09
Polar ICL3 K 214 - s15s16 C 243 C.s15s16.01
Van-der-waals ICL3 K 214 - s15s16 C 243 C.s15s16.01