Beta-arrestin-1 - TAS2R31 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R31 79.2
Beta-arrestin-1 78.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 22.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Ionic ICL2 R 123 34x55 s8s9 E 134 N.s8s9.05
Polar ICL2 R 123 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 123 34x55 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 123 34x55 s8s9 E 134 N.s8s9.05
Polar ICL2 N 112 34x44 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 N 112 34x44 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 N 112 34x44 s8s9 D 135 N.s8s9.06
Hydrophobic C-term P 309 - s9s10 E 156 N.s9s10.08
Van-der-waals C-term P 309 - s9s10 E 156 N.s9s10.08
Hydrophobic TM1 R 38 1x64 s9s10 K 160 N.s9s10.12
Van-der-waals TM1 R 38 1x64 s9s10 K 160 N.s9s10.12
Hydrophobic TM6 V 231 6x38 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 G 282 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 G 282 7x56 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 110 3x54 s8s9 K 138 N.s8s9.09
Polar TM6 S 220 6x27 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 S 220 6x27 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 S 220 6x27 s15s16 F 244 C.s15s16.03
Hydrophobic H8 N 283 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 283 8x47 s5s6 D 69 N.s5s6.06
Polar H8 N 283 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 N 283 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 N 283 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 V 223 6x30 s5s6 L 73 N.s5s6.10
Polar ICL1 K 40 - s20c E 406 C.s20c.16
Polar TM5 H 205 5x68 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 H 205 5x68 s15s16 N 245 C.s15s16.04
Van-der-waals TM5 H 205 5x68 s15s16 N 245 C.s15s16.04
Ionic TM3 K 109 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 K 109 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 109 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM7 G 282 7x56 s5s6 V 70 N.s5s6.07
Van-der-waals TM7 G 282 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 T 230 6x37 s5s6 L 71 N.s5s6.08
Aromatic TM6 H 224 6x31 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 H 224 6x31 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 L 48 2x43 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 48 2x43 s5s6 V 70 N.s5s6.07
Polar ICL2 N 112 34x44 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 N 112 34x44 s8s9 E 134 N.s8s9.05
Hydrophobic TM6 P 219 6x26 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 P 219 6x26 S6 F 75 N.S6.01
Van-der-waals TM6 P 219 6x26 S6 F 75 N.S6.01
Polar H8 K 284 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 K 284 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 284 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 Y 106 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 Y 106 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 V 223 6x30 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 V 223 6x30 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 Y 106 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 Y 106 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 198 5x61 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 110 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 110 3x54 s5s6 L 68 N.s5s6.05
Polar TM2 S 42 2x37 s20c E 405 C.s20c.15
Hydrophobic TM3 K 109 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 K 109 3x53 s5s6 L 68 N.s5s6.05
Polar ICL2 N 112 34x44 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 N 112 34x44 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 N 112 34x44 s8s9 T 136 N.s8s9.07
Hydrophobic TM5 M 209 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 M 209 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic TM2 A 44 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 A 44 2x39 s5s6 V 70 N.s5s6.07
Ionic ICL3 K 214 - s17s18 E 313 C.s17s18.39
Polar ICL3 K 214 - s17s18 E 313 C.s17s18.39
Hydrophobic ICL3 K 214 - s17s18 E 313 C.s17s18.39
Van-der-waals ICL3 K 214 - s17s18 E 313 C.s17s18.39
Hydrophobic TM5 M 209 5x72 s15s16 T 246 C.s15s16.05
Van-der-waals TM5 M 209 5x72 s15s16 T 246 C.s15s16.05
Polar H8 K 285 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 285 8x49 s5s6 D 69 N.s5s6.06
Polar H8 S 292 8x56 s9s10 K 157 N.s9s10.09
Van-der-waals H8 S 292 8x56 s9s10 K 157 N.s9s10.09
Hydrophobic TM6 A 227 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 227 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 119 34x51 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 L 119 34x51 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 M 209 5x72 s15s16 N 245 C.s15s16.04
Van-der-waals TM5 M 209 5x72 s15s16 N 245 C.s15s16.04
Hydrophobic TM3 I 110 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 110 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 V 223 6x30 S6 F 75 N.S6.01
Hydrophobic ICL2 R 123 34x55 s8s9 P 133 N.s8s9.04
Hydrophobic TM3 I 110 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 110 3x54 s5s6 L 73 N.s5s6.10
Ionic TM1 R 38 1x64 s20c E 407 C.s20c.17
Polar TM1 R 38 1x64 s20c E 407 C.s20c.17
Hydrophobic TM1 R 38 1x64 s20c E 407 C.s20c.17
Van-der-waals TM1 R 38 1x64 s20c E 407 C.s20c.17
Polar TM7 G 282 7x56 s5s6 G 72 N.s5s6.09
Hydrophobic TM7 G 282 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 G 282 7x56 s5s6 G 72 N.s5s6.09
Polar TM6 S 220 6x27 s15s16 N 245 C.s15s16.04