S-arrestin - TAS2R38 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R38 74.1
S-arrestin 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 H 223 5x68 s15s16 Y 254 C.s15s16.03
Aromatic TM5 H 223 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 H 223 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 H 223 5x68 s15s16 Y 254 C.s15s16.03
Ionic TM4 R 138 4x40 s8s9 D 142 N.s8s9.06
Polar TM4 R 138 4x40 s8s9 D 142 N.s8s9.06
Hydrophobic TM5 M 227 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 M 227 5x72 S6 R 85 N.S6.03
Polar TM4 S 137 4x39 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 S 137 4x39 s8s9 Q 141 N.s8s9.05
Polar TM4 R 138 4x40 s8s9 Q 141 N.s8s9.05
Hydrophobic TM4 R 138 4x40 s8s9 Q 141 N.s8s9.05
Van-der-waals TM4 R 138 4x40 s8s9 Q 141 N.s8s9.05
Hydrophobic TM5 Y 230 5x75 s17s18 D 321 C.s17s18.37
Polar TM1 Q 48 1x65 s20c E 395 C.s20c.14
Van-der-waals TM1 Q 48 1x65 s20c E 395 C.s20c.14
Van-der-waals TM2 S 51 2x37 s5s6 V 78 N.s5s6.07
Hydrophobic TM7 G 300 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 G 300 7x56 s5s6 I 79 N.s5s6.08
Polar H8 N 301 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic H8 N 301 8x47 s5s6 I 79 N.s5s6.08
Van-der-waals H8 N 301 8x47 s5s6 I 79 N.s5s6.08
Hydrophobic TM5 L 220 5x65 S6 F 83 N.S6.01
Hydrophobic TM6 A 241 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 241 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 M 227 5x72 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 M 227 5x72 s15s16 L 253 C.s15s16.02
Aromatic TM6 H 242 6x31 S6 F 83 N.S6.01
Hydrophobic TM6 H 242 6x31 S6 F 83 N.S6.01
Van-der-waals TM6 H 242 6x31 S6 F 83 N.S6.01
Hydrophobic H8 N 301 8x47 s5s6 G 80 N.s5s6.09
Van-der-waals H8 N 301 8x47 s5s6 G 80 N.s5s6.09
Polar ICL2 R 123 34x44 S5 Y 71 N.S5.12
Aromatic ICL2 R 123 34x44 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 123 34x44 S5 Y 71 N.S5.12
Van-der-waals ICL2 R 123 34x44 S5 Y 71 N.S5.12
Hydrophobic TM2 S 53 2x39 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 S 53 2x39 s5s6 V 78 N.s5s6.07
Hydrophobic TM6 P 237 6x26 S6 D 86 N.S6.04
Van-der-waals TM6 S 238 6x27 s15s16 Y 254 C.s15s16.03
Ionic H8 R 306 8x52 s5s6 D 77 N.s5s6.06
Polar H8 R 306 8x52 s5s6 D 77 N.s5s6.06
Hydrophobic H8 R 306 8x52 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 306 8x52 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 S 238 6x27 S6 R 85 N.S6.03
Hydrophobic TM2 L 57 2x43 s5s6 V 78 N.s5s6.07
Van-der-waals TM2 L 57 2x43 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 L 121 3x54 s5s6 I 76 N.s5s6.05
Polar ICL2 R 123 34x44 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 R 123 34x44 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 R 123 34x44 s15s16 S 255 C.s15s16.04
Polar H8 N 301 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 N 301 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 301 8x47 s5s6 V 78 N.s5s6.07
Polar ICL2 R 123 34x44 s15s16 L 253 C.s15s16.02
Hydrophobic ICL2 R 123 34x44 s15s16 L 253 C.s15s16.02
Van-der-waals ICL2 R 123 34x44 s15s16 L 253 C.s15s16.02
Hydrophobic TM6 A 245 6x34 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 S 51 2x37 s5s6 D 75 N.s5s6.04
Van-der-waals TM2 S 51 2x37 s5s6 D 75 N.s5s6.04
Hydrophobic ICL2 R 123 34x44 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 R 123 34x44 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 A 245 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 245 6x34 s5s6 L 81 N.s5s6.10
Polar ICL2 R 123 34x44 S15 V 251 C.S15.14
Hydrophobic ICL2 R 123 34x44 S15 V 251 C.S15.14
Van-der-waals ICL2 R 123 34x44 S15 V 251 C.S15.14
Polar TM6 S 238 6x27 S6 R 84 N.S6.02
Hydrophobic TM6 S 238 6x27 S6 R 84 N.S6.02
Van-der-waals TM6 S 238 6x27 S6 R 84 N.S6.02
Polar H8 N 301 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 301 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 301 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic TM6 S 248 6x37 s5s6 I 79 N.s5s6.08
Polar H8 A 302 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 A 302 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 A 302 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM3 L 121 3x54 s5s6 I 79 N.s5s6.08
Polar TM6 H 242 6x31 s15s16 Y 254 C.s15s16.03
Aromatic TM6 H 242 6x31 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 H 242 6x31 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 H 242 6x31 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 L 249 6x38 s5s6 I 79 N.s5s6.08
Hydrophobic TM2 D 54 2x40 s5s6 V 78 N.s5s6.07
Polar TM3 K 120 3x53 S5 Y 71 N.S5.12
Van-der-waals TM3 K 120 3x53 S5 Y 71 N.S5.12
Hydrophobic ICL2 R 123 34x44 S16 D 257 C.S16.01
Hydrophobic TM5 T 231 5x76 S6 R 85 N.S6.03
Van-der-waals TM5 T 231 5x76 S6 R 85 N.S6.03
Ionic TM6 D 236 6x25 S6 R 85 N.S6.03
Hydrophobic H8 A 302 8x48 s5s6 G 80 N.s5s6.09
Van-der-waals H8 A 302 8x48 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 Y 117 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 Y 117 3x50 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 L 121 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 L 121 3x54 S6 F 83 N.S6.01
Polar TM7 G 300 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM7 G 300 7x56 s5s6 G 80 N.s5s6.09
Van-der-waals TM7 G 300 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM3 K 120 3x53 s8s9 G 144 N.s8s9.08
Hydrophobic TM3 Y 117 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 Y 117 3x50 s5s6 I 79 N.s5s6.08
Polar TM3 K 120 3x53 s5s6 Q 73 N.s5s6.02
Van-der-waals TM3 K 120 3x53 s5s6 Q 73 N.s5s6.02