Beta-arrestin-2 - TAS2R39 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R39 74.0
Beta-arrestin-2 77.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar H8 N 315 8x47 s5s6 D 70 N.s5s6.06
Hydrophobic H8 P 316 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals H8 P 316 8x48 s5s6 G 73 N.s5s6.09
Polar TM3 K 138 3x53 s8s9 T 137 N.s8s9.07
Hydrophobic TM3 K 138 3x53 s8s9 T 137 N.s8s9.07
Van-der-waals TM3 K 138 3x53 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 G 259 6x33 s5s6 L 74 N.s5s6.10
Ionic TM6 D 251 6x25 S6 K 78 N.S6.03
Polar TM6 D 251 6x25 S6 K 78 N.S6.03
Hydrophobic TM6 D 251 6x25 S6 K 78 N.S6.03
Van-der-waals TM6 D 251 6x25 S6 K 78 N.S6.03
Hydrophobic TM3 F 134 3x49 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 W 152 34x55 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 W 152 34x55 s8s9 E 135 N.s8s9.05
Polar TM6 S 253 6x27 S6 R 77 N.S6.02
Hydrophobic TM3 Y 135 3x50 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 A 263 6x37 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 I 264 6x38 s5s6 L 72 N.s5s6.08
Hydrophobic TM5 M 242 5x72 s15s16 L 244 C.s15s16.02
Van-der-waals TM5 M 242 5x72 s15s16 L 244 C.s15s16.02
Polar TM7 D 314 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic TM7 D 314 7x56 s5s6 G 73 N.s5s6.09
Van-der-waals TM7 D 314 7x56 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 S 253 6x27 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 S 253 6x27 s15s16 F 245 C.s15s16.03
Ionic TM3 K 138 3x53 s5s6 D 68 N.s5s6.04
Polar TM3 K 138 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM3 K 138 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 138 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 W 152 34x55 s8s9 T 137 N.s8s9.07
Polar ICL2 R 151 34x54 s8s9 T 137 N.s8s9.07
Hydrophobic ICL2 R 151 34x54 s8s9 T 137 N.s8s9.07
Van-der-waals ICL2 R 151 34x54 s8s9 T 137 N.s8s9.07
Polar TM5 N 245 5x75 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 N 245 5x75 s17s18 E 314 C.s17s18.39
Aromatic TM6 H 257 6x31 S6 F 76 N.S6.01
Hydrophobic TM6 H 257 6x31 S6 F 76 N.S6.01
Van-der-waals TM6 H 257 6x31 S6 F 76 N.S6.01
Hydrophobic TM6 H 257 6x31 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 H 257 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic TM3 I 139 3x54 s5s6 L 69 N.s5s6.05
Van-der-waals TM3 I 139 3x54 s5s6 L 69 N.s5s6.05
Hydrophobic H8 N 315 8x47 s5s6 L 72 N.s5s6.08
Polar ICL2 N 141 34x44 s15s16 T 247 C.s15s16.05
Van-der-waals ICL2 N 141 34x44 s15s16 T 247 C.s15s16.05
Hydrophobic TM5 A 246 5x76 S6 K 78 N.S6.03
Van-der-waals TM5 A 246 5x76 S6 K 78 N.S6.03
Hydrophobic TM6 S 253 6x27 S6 F 76 N.S6.01
Van-der-waals TM6 S 253 6x27 S6 F 76 N.S6.01
Polar H8 R 320 8x52 s20c D 406 C.s20c.16
Van-der-waals H8 R 320 8x52 s20c D 406 C.s20c.16
Ionic TM3 K 138 3x53 s5s6 E 67 N.s5s6.03
Polar TM3 K 138 3x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 K 138 3x53 s5s6 E 67 N.s5s6.03
Van-der-waals TM3 K 138 3x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM4 T 155 4x39 s8s9 T 137 N.s8s9.07
Polar TM3 I 139 3x54 s5s6 R 66 N.s5s6.02
Hydrophobic TM3 I 139 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 139 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM6 F 267 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM6 F 267 6x41 s5s6 L 72 N.s5s6.08
Van-der-waals TM2 S 70 2x37 s5s6 E 67 N.s5s6.03
Polar TM2 T 71 2x38 s5s6 E 67 N.s5s6.03
Hydrophobic TM6 A 256 6x30 S6 F 76 N.S6.01
Van-der-waals TM6 A 256 6x30 S6 F 76 N.S6.01
Hydrophobic TM6 A 256 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 256 6x30 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 I 139 3x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 I 139 3x54 s5s6 D 68 N.s5s6.04
Polar TM2 S 72 2x39 s5s6 E 67 N.s5s6.03
Ionic TM5 H 241 5x71 s17s18 E 314 C.s17s18.39
Hydrophobic H8 N 315 8x47 s5s6 G 73 N.s5s6.09
Hydrophobic TM2 S 72 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 S 72 2x39 s5s6 V 71 N.s5s6.07
Polar TM5 H 238 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 238 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 238 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM7 D 314 7x56 s5s6 L 72 N.s5s6.08
Van-der-waals TM7 D 314 7x56 s5s6 L 72 N.s5s6.08
Hydrophobic ICL2 W 152 34x55 s8s9 D 136 N.s8s9.06
Van-der-waals ICL2 W 152 34x55 s8s9 D 136 N.s8s9.06
Hydrophobic TM6 A 260 6x34 s5s6 L 72 N.s5s6.08
Polar H8 N 315 8x47 s5s6 V 71 N.s5s6.07
Van-der-waals H8 N 315 8x47 s5s6 V 71 N.s5s6.07
Hydrophobic ICL2 N 141 34x44 s15s16 S 246 C.s15s16.04
Polar TM3 K 138 3x53 s5s6 R 66 N.s5s6.02
Ionic H8 R 324 8x56 s20c D 406 C.s20c.16
Hydrophobic TM3 Y 135 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 Y 135 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 A 260 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 260 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM5 M 242 5x72 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 M 242 5x72 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 S 253 6x27 S6 K 78 N.S6.03