S-arrestin - TAS2R40 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R40 76.5
S-arrestin 78.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 23.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM5 M 227 5x72 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 M 227 5x72 s15s16 Y 254 C.s15s16.03
Hydrophobic TM7 G 299 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 G 299 7x56 s5s6 I 79 N.s5s6.08
Polar TM5 H 223 5x68 s15s16 Y 254 C.s15s16.03
Aromatic TM5 H 223 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 H 223 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 H 223 5x68 s15s16 Y 254 C.s15s16.03
Polar TM5 M 227 5x72 S6 R 85 N.S6.03
Hydrophobic TM5 M 227 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 M 227 5x72 S6 R 85 N.S6.03
Ionic TM1 K 51 1x65 s20c E 395 C.s20c.14
Polar TM1 K 51 1x65 s20c E 395 C.s20c.14
Hydrophobic TM1 K 51 1x65 s20c E 395 C.s20c.14
Van-der-waals TM1 K 51 1x65 s20c E 395 C.s20c.14
Hydrophobic TM3 I 123 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 123 3x54 S6 F 83 N.S6.01
Polar TM5 N 230 5x75 s17s18 D 321 C.s17s18.37
Hydrophobic TM5 N 230 5x75 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 N 230 5x75 s17s18 D 321 C.s17s18.37
Polar TM7 G 299 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM7 G 299 7x56 s5s6 G 80 N.s5s6.09
Van-der-waals TM7 G 299 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM5 L 220 5x65 S6 F 83 N.S6.01
Hydrophobic TM6 A 241 6x30 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 241 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic TM5 M 227 5x72 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 M 227 5x72 s15s16 L 253 C.s15s16.02
Hydrophobic TM6 H 242 6x31 S6 F 83 N.S6.01
Ionic H8 R 305 8x52 s5s6 D 77 N.s5s6.06
Polar H8 R 305 8x52 s5s6 D 77 N.s5s6.06
Van-der-waals H8 R 305 8x52 s5s6 D 77 N.s5s6.06
Hydrophobic H8 P 301 8x48 s5s6 G 80 N.s5s6.09
Van-der-waals H8 P 301 8x48 s5s6 G 80 N.s5s6.09
Hydrophobic TM6 P 237 6x26 S6 D 86 N.S6.04
Hydrophobic TM6 S 238 6x27 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 S 238 6x27 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 S 238 6x27 S6 R 85 N.S6.03
Hydrophobic TM1 R 49 1x63 s20c R 398 C.s20c.17
Hydrophobic TM3 R 122 3x53 s5s6 I 76 N.s5s6.05
Van-der-waals TM3 R 122 3x53 s5s6 I 76 N.s5s6.05
Polar ICL2 N 125 34x44 s8s9 K 145 N.s8s9.09
Hydrophobic ICL2 F 132 34x51 S16 D 257 C.S16.01
Polar H8 N 300 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic H8 N 300 8x47 s5s6 V 78 N.s5s6.07
Van-der-waals H8 N 300 8x47 s5s6 V 78 N.s5s6.07
Hydrophobic TM3 Y 119 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 Y 119 3x50 s5s6 I 79 N.s5s6.08
Polar ICL2 N 125 34x44 S16 D 257 C.S16.01
Hydrophobic ICL2 N 125 34x44 S16 D 257 C.S16.01
Van-der-waals ICL2 N 125 34x44 S16 D 257 C.S16.01
Polar TM3 R 122 3x53 s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 R 122 3x53 s5s6 Q 73 N.s5s6.02
Van-der-waals TM3 R 122 3x53 s5s6 Q 73 N.s5s6.02
Hydrophobic ICL2 K 135 34x54 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 K 135 34x54 s8s9 K 145 N.s8s9.09
Hydrophobic TM6 A 245 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 245 6x34 s5s6 L 81 N.s5s6.10
Hydrophobic TM3 I 123 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 123 3x54 s5s6 L 81 N.s5s6.10
Polar TM6 S 238 6x27 S6 R 84 N.S6.02
Polar H8 P 301 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic H8 P 301 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 P 301 8x48 s5s6 D 77 N.s5s6.06
Hydrophobic TM1 K 51 1x65 s20c R 398 C.s20c.17
Van-der-waals TM1 K 51 1x65 s20c R 398 C.s20c.17
Polar ICL2 N 125 34x44 s15s16 S 255 C.s15s16.04
Hydrophobic ICL2 N 125 34x44 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 N 125 34x44 s15s16 S 255 C.s15s16.04
Hydrophobic TM6 H 242 6x31 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 A 248 6x37 s5s6 I 79 N.s5s6.08
Hydrophobic TM6 H 242 6x31 s15s16 Y 254 C.s15s16.03
Van-der-waals TM6 H 242 6x31 s15s16 Y 254 C.s15s16.03
Polar H8 N 300 8x47 s5s6 D 77 N.s5s6.06
Hydrophobic H8 N 300 8x47 s5s6 D 77 N.s5s6.06
Van-der-waals H8 N 300 8x47 s5s6 D 77 N.s5s6.06
Polar H8 G 302 8x49 s5s6 D 77 N.s5s6.06
Hydrophobic TM5 A 231 5x76 S6 R 85 N.S6.03
Van-der-waals TM5 A 231 5x76 S6 R 85 N.S6.03
Ionic TM6 D 236 6x25 S6 R 85 N.S6.03
Polar TM6 D 236 6x25 S6 R 85 N.S6.03
Hydrophobic TM6 D 236 6x25 S6 R 85 N.S6.03
Van-der-waals TM6 D 236 6x25 S6 R 85 N.S6.03
Hydrophobic ICL2 F 132 34x51 s8s9 K 145 N.s8s9.09
Van-der-waals ICL2 F 132 34x51 s8s9 K 145 N.s8s9.09
Hydrophobic TM3 Y 119 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 Y 119 3x50 s5s6 V 78 N.s5s6.07