Gq - TAS2R40 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R40 77.2
Gαq 86.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 18.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM1 Y 43 1x57 G.H5 N 357 G.H5.24
Van-der-waals TM1 Y 43 1x57 G.H5 N 357 G.H5.24
Polar TM6 S 238 6x27 G.H5 Q 350 G.H5.17
Hydrophobic TM6 S 238 6x27 G.H5 Q 350 G.H5.17
Van-der-waals TM6 S 238 6x27 G.H5 Q 350 G.H5.17
Polar TM6 H 242 6x31 G.H5 Q 350 G.H5.17
Hydrophobic TM6 H 242 6x31 G.H5 Q 350 G.H5.17
Van-der-waals TM6 H 242 6x31 G.H5 Q 350 G.H5.17
Hydrophobic TM6 A 241 6x30 G.H5 Q 350 G.H5.17
Hydrophobic TM7 G 299 7x56 G.H5 V 359 G.H5.26
Van-der-waals TM7 G 299 7x56 G.H5 V 359 G.H5.26
Hydrophobic TM6 A 248 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 248 6x37 G.H5 L 358 G.H5.25
Ionic H8 R 305 8x52 G.h4s6 D 319 G.h4s6.10
Polar H8 R 305 8x52 G.h4s6 D 319 G.h4s6.10
Van-der-waals H8 R 305 8x52 G.h4s6 D 319 G.h4s6.10
Ionic H8 R 305 8x52 G.h4s6 D 321 G.h4s6.12
Polar H8 R 305 8x52 G.h4s6 D 321 G.h4s6.12
Hydrophobic H8 R 305 8x52 G.h4s6 D 321 G.h4s6.12
Van-der-waals H8 R 305 8x52 G.h4s6 D 321 G.h4s6.12
Hydrophobic TM6 A 245 6x34 G.H5 V 359 G.H5.26
Van-der-waals TM6 A 245 6x34 G.H5 V 359 G.H5.26
Polar ICL1 T 52 - G.hns1 R 37 G.hns1.02
Van-der-waals ICL1 T 52 - G.hns1 R 37 G.hns1.02
Van-der-waals TM6 A 245 6x34 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 245 6x34 G.H5 L 353 G.H5.20
Hydrophobic TM6 P 237 6x26 G.h4s6 I 323 G.h4s6.20
Van-der-waals TM6 P 237 6x26 G.h4s6 I 323 G.h4s6.20
Hydrophobic TM3 K 116 3x47 G.H5 L 358 G.H5.25
Van-der-waals TM3 K 116 3x47 G.H5 L 358 G.H5.25
Ionic TM5 H 223 5x68 G.H5 D 346 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 346 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 346 G.H5.13
Polar ICL2 N 125 34x44 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 N 125 34x44 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM5 M 227 5x72 G.H5 A 343 G.H5.10
Hydrophobic TM6 P 237 6x26 G.S6 Y 325 G.S6.02
Hydrophobic TM6 S 238 6x27 G.S6 Y 325 G.S6.02
Polar TM3 R 122 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 122 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 122 3x53 G.H5 Y 356 G.H5.23
Polar TM3 Y 119 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 Y 119 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 Y 119 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 123 3x54 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 123 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 353 G.H5.20
Hydrophobic TM5 A 231 5x76 G.H5 F 339 G.H5.06
Hydrophobic ICL2 N 125 34x44 G.H5 L 349 G.H5.16
Van-der-waals ICL2 N 125 34x44 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 123 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 123 3x54 G.H5 L 358 G.H5.25
Aromatic TM3 F 118 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM3 F 118 3x49 G.H5 Y 356 G.H5.23
Van-der-waals TM3 F 118 3x49 G.H5 Y 356 G.H5.23
Polar TM3 R 122 3x53 G.hns1 R 37 G.hns1.02
Polar TM3 Y 119 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM3 Y 119 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 Y 119 3x50 G.H5 N 357 G.H5.24
Hydrophobic ICL2 F 132 34x51 G.s2s3 S 198 G.s2s3.02
Van-der-waals ICL2 F 132 34x51 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM2 M 60 2x43 G.H5 N 357 G.H5.24
Van-der-waals TM2 M 60 2x43 G.H5 N 357 G.H5.24
Polar ICL2 K 135 34x54 G.s2s3 S 198 G.s2s3.02
Hydrophobic TM5 M 227 5x72 G.H5 D 346 G.H5.13
Van-der-waals TM5 M 227 5x72 G.H5 D 346 G.H5.13
Hydrophobic TM5 N 230 5x75 G.H5 F 339 G.H5.06
Van-der-waals TM5 N 230 5x75 G.H5 F 339 G.H5.06
Polar H8 N 300 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 300 8x47 G.H5 N 357 G.H5.24
Hydrophobic ICL2 R 136 34x55 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 R 136 34x55 G.hns1 R 38 G.hns1.03
Polar H8 N 300 8x47 G.H5 V 359 G.H5.26
Hydrophobic H8 N 300 8x47 G.H5 V 359 G.H5.26
Van-der-waals H8 N 300 8x47 G.H5 V 359 G.H5.26
Hydrophobic ICL2 F 132 34x51 G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL2 F 132 34x51 G.s2s3 Q 197 G.s2s3.01
Hydrophobic TM4 V 140 4x40 G.HN R 34 G.HN.52
Van-der-waals TM4 V 140 4x40 G.HN R 34 G.HN.52
Hydrophobic TM3 Y 119 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 Y 119 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 249 6x38 G.H5 L 358 G.H5.25
Hydrophobic TM6 H 242 6x31 G.H5 L 353 G.H5.20
Hydrophobic TM3 I 123 3x54 G.H5 Y 356 G.H5.23
Hydrophobic TM5 L 216 5x61 G.H5 L 358 G.H5.25
Van-der-waals TM5 L 216 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM5 L 220 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM7 L 296 7x53 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 296 7x53 G.H5 N 357 G.H5.24