Beta-arrestin-1 - TAS2R42 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R42 78.4
Beta-arrestin-1 78.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 24.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 120 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 L 120 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 L 120 34x51 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 L 120 34x51 s8s9 E 134 N.s8s9.05
Polar TM6 S 225 6x27 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 S 225 6x27 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 S 225 6x27 s15s16 F 244 C.s15s16.03
Polar TM1 N 38 1x64 s9s10 K 160 N.s9s10.12
Van-der-waals TM1 N 38 1x64 s9s10 K 160 N.s9s10.12
Hydrophobic TM7 G 287 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 G 287 7x56 s5s6 L 71 N.s5s6.08
Polar ICL2 W 124 34x55 s8s9 P 133 N.s8s9.04
Hydrophobic ICL2 W 124 34x55 s8s9 P 133 N.s8s9.04
Van-der-waals ICL2 W 124 34x55 s8s9 P 133 N.s8s9.04
Hydrophobic TM2 F 42 2x37 s5s6 D 67 N.s5s6.04
Van-der-waals TM2 F 42 2x37 s5s6 D 67 N.s5s6.04
Polar TM5 L 214 5x72 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 L 214 5x72 s15s16 T 246 C.s15s16.05
Van-der-waals TM5 L 214 5x72 s15s16 T 246 C.s15s16.05
Polar TM5 H 210 5x68 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 H 210 5x68 s15s16 N 245 C.s15s16.04
Van-der-waals TM5 H 210 5x68 s15s16 N 245 C.s15s16.04
Polar ICL1 K 40 - s20c K 403 C.s20c.13
Van-der-waals ICL1 K 40 - s20c K 403 C.s20c.13
Polar ICL1 K 40 - s20c E 406 C.s20c.16
Hydrophobic ICL1 K 40 - s20c E 406 C.s20c.16
Van-der-waals ICL1 K 40 - s20c E 406 C.s20c.16
Hydrophobic H8 S 289 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 H 113 34x44 s8s9 D 135 N.s8s9.06
Polar ICL2 R 123 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 R 123 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 R 123 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL1 K 40 - s20c E 407 C.s20c.17
Polar ICL2 H 113 34x44 S16 Y 249 C.S16.03
Hydrophobic TM3 Y 107 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 Y 107 3x50 s5s6 V 70 N.s5s6.07
Polar ICL3 G 220 - s17s18 E 313 C.s17s18.39
Polar ICL2 H 113 34x44 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 H 113 34x44 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 H 113 34x44 s8s9 T 136 N.s8s9.07
Hydrophobic TM6 A 228 6x30 S6 F 75 N.S6.01
Hydrophobic TM3 F 106 3x49 s5s6 V 70 N.s5s6.07
Polar H8 K 290 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 K 290 8x49 s5s6 D 69 N.s5s6.06
Polar TM6 H 229 6x31 s15s16 F 244 C.s15s16.03
Aromatic TM6 H 229 6x31 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 H 229 6x31 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 H 229 6x31 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 I 111 3x54 s5s6 L 71 N.s5s6.08
Polar TM5 H 210 5x68 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 H 210 5x68 s15s16 T 246 C.s15s16.05
Van-der-waals TM5 H 210 5x68 s15s16 T 246 C.s15s16.05
Hydrophobic TM6 A 228 6x30 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 A 228 6x30 s15s16 F 244 C.s15s16.03
Hydrophobic TM3 Y 107 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 Y 107 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 M 235 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 S 218 5x76 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 S 218 5x76 s17s18 E 313 C.s17s18.39
Hydrophobic TM6 F 239 6x41 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 F 239 6x41 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 D 223 6x25 s17s18 E 313 C.s17s18.39
Van-der-waals TM6 D 223 6x25 s17s18 E 313 C.s17s18.39
Polar TM7 G 287 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 G 287 7x56 s5s6 G 72 N.s5s6.09
Ionic TM6 D 223 6x25 S6 K 77 N.S6.03
Hydrophobic TM3 K 110 3x53 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 K 110 3x53 s5s6 L 68 N.s5s6.05
Hydrophobic TM6 A 232 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 232 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic TM2 F 42 2x37 s5s6 E 66 N.s5s6.03
Van-der-waals TM2 F 42 2x37 s5s6 E 66 N.s5s6.03
Polar ICL2 R 123 34x54 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 R 123 34x54 s8s9 G 137 N.s8s9.08
Hydrophobic TM2 A 44 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 V 236 6x38 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 V 236 6x38 s5s6 L 71 N.s5s6.08
Polar H8 N 288 8x47 s5s6 D 69 N.s5s6.06
Hydrophobic H8 N 288 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 N 288 8x47 s5s6 D 69 N.s5s6.06
Polar TM6 H 229 6x31 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 H 229 6x31 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 203 5x61 s5s6 L 71 N.s5s6.08
Polar TM6 S 224 6x26 S6 K 77 N.S6.03
Van-der-waals TM6 S 224 6x26 S6 K 77 N.S6.03
Ionic TM3 K 110 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 K 110 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 110 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 I 111 3x54 s5s6 L 73 N.s5s6.10
Van-der-waals TM3 I 111 3x54 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 S 224 6x26 S6 F 75 N.S6.01
Polar ICL2 R 123 34x54 s8s9 D 135 N.s8s9.06
Hydrophobic ICL2 R 123 34x54 s8s9 D 135 N.s8s9.06
Van-der-waals ICL2 R 123 34x54 s8s9 D 135 N.s8s9.06
Polar ICL1 K 40 - s20c E 404 C.s20c.14
Van-der-waals ICL1 K 40 - s20c E 404 C.s20c.14
Hydrophobic TM3 I 111 3x54 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 I 111 3x54 s5s6 V 70 N.s5s6.07
Polar H8 S 289 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 S 289 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 S 289 8x48 s5s6 D 69 N.s5s6.06
Polar TM1 N 38 1x64 s20c E 407 C.s20c.17
Hydrophobic TM1 N 38 1x64 s20c E 407 C.s20c.17
Van-der-waals TM1 N 38 1x64 s20c E 407 C.s20c.17
Hydrophobic TM6 S 225 6x27 s15s16 L 243 C.s15s16.02
Polar ICL2 H 113 34x44 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 H 113 34x44 s8s9 G 137 N.s8s9.08
Van-der-waals ICL2 H 113 34x44 s8s9 G 137 N.s8s9.08
Hydrophobic ICL2 F 119 34x50 s8s9 T 136 N.s8s9.07