Arrestin-C - TAS2R50 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R50 79.6
Arrestin-C 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.8


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar TM5 K 208 5x71 s15s16 L 243 C.s15s16.05
Hydrophobic TM5 K 208 5x71 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 K 208 5x71 s15s16 L 243 C.s15s16.05
Polar H8 K 284 8x48 s5s6 T 70 N.s5s6.11
Van-der-waals H8 K 284 8x48 s5s6 T 70 N.s5s6.11
Polar ICL2 N 112 34x44 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 N 112 34x44 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 N 112 34x44 s8s9 A 133 N.s8s9.07
Hydrophobic TM5 M 209 5x72 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 M 209 5x72 s15s16 S 242 C.s15s16.04
Polar TM1 W 35 1x61 s20c E 386 C.s20c.20
Polar TM5 G 213 5x76 s17s18 E 310 C.s17s18.39
Hydrophobic TM5 G 213 5x76 s17s18 E 310 C.s17s18.39
Van-der-waals TM5 G 213 5x76 s17s18 E 310 C.s17s18.39
Hydrophobic TM6 S 220 6x27 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 S 220 6x27 s15s16 Y 241 C.s15s16.03
Polar ICL2 N 112 34x44 S5 Y 59 N.S5.12
Polar TM3 Y 106 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 Y 106 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 Y 106 3x50 s5s6 V 66 N.s5s6.07
Ionic TM3 K 109 3x53 s5s6 D 63 N.s5s6.04
Polar TM3 K 109 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 K 109 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 K 109 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM1 R 38 1x64 s20c D 385 C.s20c.19
Van-der-waals TM1 R 38 1x64 s20c D 385 C.s20c.19
Hydrophobic TM3 I 110 3x54 s5s6 D 63 N.s5s6.04
Hydrophobic TM5 H 212 5x75 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 H 212 5x75 s15s16 L 243 C.s15s16.05
Van-der-waals TM1 R 38 1x64 s20c G 387 C.s20c.21
Polar TM6 H 224 6x31 s15s16 Y 241 C.s15s16.03
Aromatic TM6 H 224 6x31 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 H 224 6x31 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 H 224 6x31 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 I 110 3x54 s5s6 L 64 N.s5s6.05
Polar TM5 K 208 5x71 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 K 208 5x71 s15s16 S 242 C.s15s16.04
Hydrophobic TM6 L 231 6x38 s5s6 I 67 N.s5s6.08
Polar ICL2 R 123 34x55 s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 R 123 34x55 s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 R 123 34x55 s8s9 P 130 N.s8s9.04
Hydrophobic TM7 R 282 7x56 s5s6 I 67 N.s5s6.08
Van-der-waals TM7 R 282 7x56 s5s6 I 67 N.s5s6.08
Polar TM1 R 38 1x64 s20c G 384 C.s20c.18
Hydrophobic TM1 R 38 1x64 s20c G 384 C.s20c.18
Van-der-waals TM1 R 38 1x64 s20c G 384 C.s20c.18
Polar TM7 R 282 7x56 s5s6 G 68 N.s5s6.09
Van-der-waals TM7 R 282 7x56 s5s6 G 68 N.s5s6.09
Polar TM1 R 38 1x64 s20c A 382 C.s20c.15
Hydrophobic TM1 R 38 1x64 s20c A 382 C.s20c.15
Van-der-waals TM1 R 38 1x64 s20c A 382 C.s20c.15
Hydrophobic TM5 M 209 5x72 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 M 209 5x72 s15s16 L 243 C.s15s16.05
Polar TM5 H 205 5x68 s15s16 Y 241 C.s15s16.03
Aromatic TM5 H 205 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 205 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 205 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM3 F 105 3x49 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 110 3x54 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 I 110 3x54 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 L 219 6x26 S6 K 73 N.S6.03
Hydrophobic TM5 L 198 5x61 s5s6 I 67 N.s5s6.08
Polar TM5 H 205 5x68 s15s16 S 242 C.s15s16.04
Hydrophobic TM5 H 205 5x68 s15s16 S 242 C.s15s16.04
Van-der-waals TM5 H 205 5x68 s15s16 S 242 C.s15s16.04
Hydrophobic H8 K 284 8x48 s5s6 G 68 N.s5s6.09
Van-der-waals H8 K 284 8x48 s5s6 G 68 N.s5s6.09
Hydrophobic TM1 D 34 1x60 s20c E 386 C.s20c.20
Van-der-waals TM1 D 34 1x60 s20c E 386 C.s20c.20
Hydrophobic ICL2 L 119 34x51 s8s9 A 133 N.s8s9.07
Hydrophobic TM6 V 223 6x30 S6 F 71 N.S6.01
Hydrophobic TM3 Y 106 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 L 219 6x26 S6 F 71 N.S6.01
Hydrophobic TM6 V 223 6x30 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 V 223 6x30 s5s6 L 69 N.s5s6.10
Hydrophobic ICL1 K 40 - s20c A 379 C.s20c.12
Van-der-waals ICL1 K 40 - s20c A 379 C.s20c.12
Polar TM3 K 109 3x53 s8s9 K 135 N.s8s9.09
Hydrophobic TM3 K 109 3x53 s8s9 K 135 N.s8s9.09
Van-der-waals TM3 K 109 3x53 s8s9 K 135 N.s8s9.09
Polar H8 H 288 8x52 s20c S 388 C.s20c.22
Hydrophobic H8 H 288 8x52 s20c S 388 C.s20c.22
Van-der-waals H8 H 288 8x52 s20c S 388 C.s20c.22
Hydrophobic H8 T 283 8x47 s5s6 G 68 N.s5s6.09
Hydrophobic TM6 A 227 6x34 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 227 6x34 s5s6 L 69 N.s5s6.10
Ionic H8 K 285 8x49 s20c E 386 C.s20c.20
Polar H8 K 285 8x49 s20c E 386 C.s20c.20
Hydrophobic H8 K 285 8x49 s20c E 386 C.s20c.20
Van-der-waals H8 K 285 8x49 s20c E 386 C.s20c.20
Polar TM1 R 38 1x64 s20c E 383 C.s20c.17
Hydrophobic TM1 R 38 1x64 s20c E 383 C.s20c.17
Van-der-waals TM1 R 38 1x64 s20c E 383 C.s20c.17
Hydrophobic TM2 A 44 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 A 44 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 110 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 110 3x54 s5s6 I 67 N.s5s6.08
Ionic ICL2 R 123 34x55 s8s9 E 131 N.s8s9.05
Polar ICL2 R 123 34x55 s8s9 E 131 N.s8s9.05
Hydrophobic ICL2 R 123 34x55 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 R 123 34x55 s8s9 E 131 N.s8s9.05
Hydrophobic TM5 M 209 5x72 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 M 209 5x72 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 S 220 6x27 S6 F 71 N.S6.01
Van-der-waals TM6 S 220 6x27 S6 F 71 N.S6.01
Polar ICL2 K 122 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 K 122 34x54 s8s9 A 133 N.s8s9.07
Ionic TM6 D 218 6x25 S6 K 73 N.S6.03
Polar TM6 D 218 6x25 S6 K 73 N.S6.03
Van-der-waals TM6 D 218 6x25 S6 K 73 N.S6.03
Ionic TM1 R 38 1x64 s20c E 386 C.s20c.20
Polar TM1 R 38 1x64 s20c E 386 C.s20c.20
Hydrophobic TM1 R 38 1x64 s20c E 386 C.s20c.20
Van-der-waals TM1 R 38 1x64 s20c E 386 C.s20c.20
Ionic TM5 K 208 5x71 S16 D 244 C.S16.01
Polar TM5 K 208 5x71 S16 D 244 C.S16.01
Van-der-waals TM5 K 208 5x71 S16 D 244 C.S16.01