Beta-arrestin-2 - TAS2R60 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R60 75.2
Beta-arrestin-2 79.8
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.7


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 Y 118 3x50 s5s6 L 72 N.s5s6.08
Ionic TM6 E 236 6x25 S6 K 78 N.S6.03
Hydrophobic TM6 E 236 6x25 S6 K 78 N.S6.03
Van-der-waals TM6 E 236 6x25 S6 K 78 N.S6.03
Hydrophobic TM3 F 117 3x49 s5s6 V 71 N.s5s6.07
Polar TM4 S 138 4x39 s8s9 T 137 N.s8s9.07
Hydrophobic TM5 T 231 5x76 S6 K 78 N.S6.03
Van-der-waals TM5 T 231 5x76 S6 K 78 N.S6.03
Polar H8 R 302 8x49 s20c Q 407 C.s20c.17
Hydrophobic H8 R 302 8x49 s20c Q 407 C.s20c.17
Hydrophobic TM3 I 122 3x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 I 122 3x54 s5s6 D 68 N.s5s6.04
Van-der-waals TM5 T 230 5x75 s17s18 E 314 C.s17s18.39
Hydrophobic TM3 K 121 3x53 s5s6 D 68 N.s5s6.04
Van-der-waals TM3 K 121 3x53 s5s6 D 68 N.s5s6.04
Hydrophobic TM6 A 245 6x34 s5s6 L 72 N.s5s6.08
Hydrophobic H8 N 300 8x47 s5s6 G 73 N.s5s6.09
Polar TM3 Y 118 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 Y 118 3x50 s5s6 V 71 N.s5s6.07
Van-der-waals TM3 Y 118 3x50 s5s6 V 71 N.s5s6.07
Hydrophobic TM3 I 122 3x54 s5s6 L 72 N.s5s6.08
Van-der-waals TM3 I 122 3x54 s5s6 L 72 N.s5s6.08
Hydrophobic TM2 L 53 2x37 s8s9 T 137 N.s8s9.07
Van-der-waals TM2 L 53 2x37 s8s9 T 137 N.s8s9.07
Ionic TM3 K 121 3x53 s5s6 E 67 N.s5s6.03
Polar TM3 K 121 3x53 s5s6 E 67 N.s5s6.03
Hydrophobic TM3 K 121 3x53 s5s6 E 67 N.s5s6.03
Van-der-waals TM3 K 121 3x53 s5s6 E 67 N.s5s6.03
Ionic TM5 K 226 5x71 s17s18 E 314 C.s17s18.39
Polar TM5 K 226 5x71 s17s18 E 314 C.s17s18.39
Van-der-waals TM5 K 226 5x71 s17s18 E 314 C.s17s18.39
Polar TM6 S 238 6x27 S6 R 77 N.S6.02
Hydrophobic TM6 K 244 6x33 s5s6 L 74 N.s5s6.10
Hydrophobic TM6 A 245 6x34 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 245 6x34 s5s6 L 74 N.s5s6.10
Hydrophobic TM3 K 121 3x53 s5s6 V 71 N.s5s6.07
Ionic ICL2 H 135 34x55 s8s9 E 135 N.s8s9.05
Polar ICL2 H 135 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic ICL2 H 135 34x55 s8s9 E 135 N.s8s9.05
Van-der-waals ICL2 H 135 34x55 s8s9 E 135 N.s8s9.05
Hydrophobic TM3 I 122 3x54 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 L 249 6x38 s5s6 L 72 N.s5s6.08
Polar TM2 C 55 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM2 C 55 2x39 s5s6 V 71 N.s5s6.07
Van-der-waals TM2 C 55 2x39 s5s6 V 71 N.s5s6.07
Hydrophobic TM6 S 238 6x27 S6 F 76 N.S6.01
Aromatic TM6 H 242 6x31 S6 F 76 N.S6.01
Hydrophobic TM6 H 242 6x31 S6 F 76 N.S6.01
Van-der-waals TM6 H 242 6x31 S6 F 76 N.S6.01
Polar H8 C 301 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic H8 C 301 8x48 s5s6 G 73 N.s5s6.09
Van-der-waals H8 C 301 8x48 s5s6 G 73 N.s5s6.09
Hydrophobic TM6 A 241 6x30 S6 F 76 N.S6.01
Hydrophobic ICL2 T 124 34x44 s15s16 F 245 C.s15s16.03
Hydrophobic TM6 A 241 6x30 s5s6 L 74 N.s5s6.10
Van-der-waals TM6 A 241 6x30 s5s6 L 74 N.s5s6.10
Aromatic TM5 H 223 5x68 s15s16 F 245 C.s15s16.03
Hydrophobic TM5 H 223 5x68 s15s16 F 245 C.s15s16.03
Van-der-waals TM5 H 223 5x68 s15s16 F 245 C.s15s16.03
Ionic ICL2 K 134 34x54 s5s6 D 68 N.s5s6.04
Polar ICL2 K 134 34x54 s5s6 D 68 N.s5s6.04
Hydrophobic ICL2 K 134 34x54 s5s6 D 68 N.s5s6.04
Van-der-waals ICL2 K 134 34x54 s5s6 D 68 N.s5s6.04
Hydrophobic TM2 P 54 2x38 s8s9 T 137 N.s8s9.07
Hydrophobic TM6 H 242 6x31 s15s16 F 245 C.s15s16.03
Van-der-waals TM6 H 242 6x31 s15s16 F 245 C.s15s16.03
Hydrophobic ICL2 T 124 34x44 s15s16 S 246 C.s15s16.04
Hydrophobic TM2 L 53 2x37 s5s6 D 70 N.s5s6.06