Arrestin-C - TAS2R60 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

Chain pLDDT score avg
TAS2R60 75.0
Arrestin-C 79.3
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.9


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 131 34x51 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 F 131 34x51 s8s9 A 133 N.s8s9.07
Polar TM6 H 242 6x31 s5s6 R 61 N.s5s6.02
Hydrophobic TM6 H 242 6x31 s5s6 R 61 N.s5s6.02
Van-der-waals TM6 H 242 6x31 s5s6 R 61 N.s5s6.02
Ionic ICL2 K 134 34x54 s5s6 D 63 N.s5s6.04
Polar ICL2 K 134 34x54 s5s6 D 63 N.s5s6.04
Van-der-waals ICL2 K 134 34x54 s5s6 D 63 N.s5s6.04
Hydrophobic TM1 R 50 1x65 s20c E 383 C.s20c.17
Van-der-waals TM1 R 50 1x65 s20c E 383 C.s20c.17
Polar TM3 Y 118 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 Y 118 3x50 s5s6 V 66 N.s5s6.07
Van-der-waals TM3 Y 118 3x50 s5s6 V 66 N.s5s6.07
Hydrophobic ICL2 T 124 34x44 s8s9 K 135 N.s8s9.09
Hydrophobic TM6 P 237 6x26 S6 K 73 N.S6.03
Hydrophobic TM6 A 245 6x34 s5s6 L 64 N.s5s6.05
Van-der-waals TM6 A 245 6x34 s5s6 L 64 N.s5s6.05
Hydrophobic TM5 T 231 5x76 s17s18 E 310 C.s17s18.39
Hydrophobic TM7 S 299 7x56 s5s6 L 69 N.s5s6.10
Van-der-waals TM7 S 299 7x56 s5s6 L 69 N.s5s6.10
Hydrophobic TM3 Y 118 3x50 s5s6 I 67 N.s5s6.08
Hydrophobic TM6 A 245 6x34 s5s6 I 67 N.s5s6.08
Polar H8 C 301 8x48 s5s6 G 68 N.s5s6.09
Van-der-waals H8 C 301 8x48 s5s6 G 68 N.s5s6.09
Hydrophobic TM3 F 117 3x49 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 K 121 3x53 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 K 121 3x53 s5s6 D 63 N.s5s6.04
Hydrophobic TM6 L 249 6x38 s5s6 I 67 N.s5s6.08
Van-der-waals TM6 L 249 6x38 s5s6 I 67 N.s5s6.08
Polar H8 N 300 8x47 s5s6 I 67 N.s5s6.08
Hydrophobic H8 N 300 8x47 s5s6 I 67 N.s5s6.08
Polar ICL1 M 51 - s20c E 383 C.s20c.17
Hydrophobic ICL1 M 51 - s20c E 383 C.s20c.17
Van-der-waals ICL1 M 51 - s20c E 383 C.s20c.17
Polar H8 K 308 8x55 s9s10 T 154 N.s9s10.09
Van-der-waals H8 K 308 8x55 s9s10 T 154 N.s9s10.09
Hydrophobic TM1 L 48 1x63 s20c G 387 C.s20c.21
Van-der-waals TM1 L 48 1x63 s20c G 387 C.s20c.21
Hydrophobic TM1 L 48 1x63 s20c E 383 C.s20c.17
Van-der-waals TM1 L 48 1x63 s20c E 383 C.s20c.17
Polar TM3 I 122 3x54 s5s6 D 63 N.s5s6.04
Hydrophobic TM3 I 122 3x54 s5s6 D 63 N.s5s6.04
Van-der-waals TM3 I 122 3x54 s5s6 D 63 N.s5s6.04
Polar ICL2 H 135 34x55 s17s18 R 282 C.s17s18.11
Van-der-waals ICL2 H 135 34x55 s17s18 R 282 C.s17s18.11
Hydrophobic TM3 K 121 3x53 s5s6 V 66 N.s5s6.07
Hydrophobic TM3 I 122 3x54 s5s6 I 67 N.s5s6.08
Van-der-waals TM3 I 122 3x54 s5s6 I 67 N.s5s6.08
Polar ICL2 K 134 34x54 s8s9 A 133 N.s8s9.07
Van-der-waals ICL2 K 134 34x54 s8s9 A 133 N.s8s9.07
Hydrophobic ICL2 F 131 34x51 s8s9 D 132 N.s8s9.06
Van-der-waals ICL2 F 131 34x51 s8s9 D 132 N.s8s9.06
Polar ICL2 H 135 34x55 s8s9 P 130 N.s8s9.04
Hydrophobic ICL2 H 135 34x55 s8s9 P 130 N.s8s9.04
Van-der-waals ICL2 H 135 34x55 s8s9 P 130 N.s8s9.04
Hydrophobic TM6 K 244 6x33 s5s6 L 69 N.s5s6.10
Hydrophobic TM5 T 230 5x75 s15s16 L 243 C.s15s16.05
Van-der-waals TM5 T 230 5x75 s15s16 L 243 C.s15s16.05
Polar TM6 S 238 6x27 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 S 238 6x27 s15s16 Y 241 C.s15s16.03
Van-der-waals TM6 S 238 6x27 s15s16 Y 241 C.s15s16.03
Ionic TM6 E 236 6x25 S6 K 73 N.S6.03
Polar TM6 E 236 6x25 S6 K 73 N.S6.03
Van-der-waals TM6 E 236 6x25 S6 K 73 N.S6.03
Hydrophobic H8 N 300 8x47 s5s6 G 68 N.s5s6.09
Van-der-waals H8 N 300 8x47 s5s6 G 68 N.s5s6.09
Ionic TM1 R 50 1x65 s20c E 386 C.s20c.20
Polar TM1 R 50 1x65 s20c E 386 C.s20c.20
Hydrophobic TM1 R 50 1x65 s20c E 386 C.s20c.20
Van-der-waals TM1 R 50 1x65 s20c E 386 C.s20c.20
Polar TM5 H 223 5x68 s5s6 R 61 N.s5s6.02
Aromatic TM5 H 223 5x68 s5s6 R 61 N.s5s6.02
Hydrophobic TM5 H 223 5x68 s5s6 R 61 N.s5s6.02
Van-der-waals TM5 H 223 5x68 s5s6 R 61 N.s5s6.02
Polar TM1 R 49 1x64 s20c E 383 C.s20c.17
Hydrophobic TM1 R 49 1x64 s20c E 383 C.s20c.17
Van-der-waals TM1 R 49 1x64 s20c E 383 C.s20c.17
Hydrophobic TM6 A 248 6x37 s5s6 I 67 N.s5s6.08
Polar H8 C 301 8x48 s5s6 T 70 N.s5s6.11
Hydrophobic TM3 I 122 3x54 s5s6 L 64 N.s5s6.05
Hydrophobic TM6 A 241 6x30 S6 F 71 N.S6.01
Van-der-waals TM6 A 241 6x30 S6 F 71 N.S6.01
Hydrophobic ICL2 F 131 34x51 s8s9 E 131 N.s8s9.05
Van-der-waals ICL2 F 131 34x51 s8s9 E 131 N.s8s9.05
Hydrophobic TM6 H 242 6x31 S6 F 71 N.S6.01
Polar TM5 H 223 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM5 H 223 5x68 s15s16 Y 241 C.s15s16.03
Van-der-waals TM5 H 223 5x68 s15s16 Y 241 C.s15s16.03
Hydrophobic TM6 S 238 6x27 S6 F 71 N.S6.01
Hydrophobic TM5 L 220 5x65 s5s6 L 64 N.s5s6.05
Polar TM2 C 55 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM2 C 55 2x39 s5s6 V 66 N.s5s6.07
Van-der-waals TM2 C 55 2x39 s5s6 V 66 N.s5s6.07
Hydrophobic TM6 A 245 6x34 s5s6 L 69 N.s5s6.10
Van-der-waals TM6 A 245 6x34 s5s6 L 69 N.s5s6.10