Beta-arrestin-1 - TAS2R1 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R1 78.0
Beta-arrestin-1 80.4
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.3


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 120 34x55 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 M 120 34x55 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 S 109 34x44 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 S 109 34x44 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 M 120 34x55 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 M 120 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 M 208 5x72 s15s16 L 243 C.s15s16.02
Hydrophobic TM6 A 222 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 222 6x30 s5s6 L 73 N.s5s6.10
Polar H8 N 281 8x47 s5s6 D 69 N.s5s6.06
Polar H8 P 282 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 P 282 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 P 282 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic TM3 Y 103 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals ICL2 K 119 34x54 s5s6 R 65 N.s5s6.02
Polar TM3 Y 103 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 Y 103 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 Y 103 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 V 212 5x76 S6 K 77 N.S6.03
Van-der-waals TM5 V 212 5x76 S6 K 77 N.S6.03
Polar TM7 G 280 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 G 280 7x56 s5s6 G 72 N.s5s6.09
Hydrophobic TM3 V 107 3x54 s5s6 L 73 N.s5s6.10
Polar ICL2 R 111 34x46 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 R 111 34x46 s15s16 T 246 C.s15s16.05
Hydrophobic TM5 L 201 5x65 s5s6 L 73 N.s5s6.10
Aromatic TM5 H 204 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 204 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 204 5x68 s15s16 F 244 C.s15s16.03
Polar TM5 T 211 5x75 S6 K 77 N.S6.03
Hydrophobic TM5 T 211 5x75 S6 K 77 N.S6.03
Van-der-waals TM5 T 211 5x75 S6 K 77 N.S6.03
Ionic ICL3 R 216 - s9s10 E 155 N.s9s10.07
Polar ICL3 R 216 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 R 216 - s9s10 E 155 N.s9s10.07
Hydrophobic TM6 I 230 6x38 s5s6 L 71 N.s5s6.08
Hydrophobic TM5 L 201 5x65 S6 F 75 N.S6.01
Hydrophobic ICL2 M 120 34x55 s8s9 D 135 N.s8s9.06
Hydrophobic TM3 V 107 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 V 107 3x54 s5s6 L 68 N.s5s6.05
Polar H8 N 281 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic H8 N 281 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 M 208 5x72 S6 K 77 N.S6.03
Van-der-waals TM3 V 107 3x54 s5s6 D 67 N.s5s6.04
Polar TM3 V 107 3x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 V 107 3x54 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 V 107 3x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 V 107 3x54 s5s6 L 71 N.s5s6.08
Polar TM3 K 106 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 K 106 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 K 106 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM7 G 280 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 G 280 7x56 s5s6 L 71 N.s5s6.08
Ionic TM3 K 106 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 K 106 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 K 106 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 106 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 I 116 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 I 116 34x51 s8s9 T 136 N.s8s9.07
Hydrophobic TM6 S 229 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic TM2 L 44 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 L 44 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 A 226 6x34 s5s6 L 71 N.s5s6.08
Polar TM3 A 108 3x55 s5s6 R 65 N.s5s6.02
Polar TM3 K 106 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 K 106 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 K 106 3x53 s8s9 K 138 N.s8s9.09
Aromatic TM5 H 204 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 H 204 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 H 204 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 T 211 5x75 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 T 211 5x75 s17s18 E 313 C.s17s18.39
Hydrophobic TM6 A 226 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 226 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 P 223 6x31 S6 F 75 N.S6.01
Hydrophobic TM6 P 223 6x31 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 P 223 6x31 s5s6 L 73 N.s5s6.10
Hydrophobic TM5 M 208 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 M 208 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic H8 P 282 8x48 s5s6 G 72 N.s5s6.09
Van-der-waals H8 P 282 8x48 s5s6 G 72 N.s5s6.09
Hydrophobic ICL2 K 119 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 K 119 34x54 s8s9 T 136 N.s8s9.07