Beta-arrestin-1 - TAS2R4 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R4 80.4
Beta-arrestin-1 79.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.4


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Polar ICL3 W 218 - S6 D 78 N.S6.04
Hydrophobic ICL3 W 218 - S6 D 78 N.S6.04
Van-der-waals ICL3 W 218 - S6 D 78 N.S6.04
Ionic ICL2 R 123 34x55 s8s9 E 134 N.s8s9.05
Polar ICL2 R 123 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic ICL2 R 123 34x55 s8s9 E 134 N.s8s9.05
Van-der-waals ICL2 R 123 34x55 s8s9 E 134 N.s8s9.05
Hydrophobic TM5 M 210 5x72 S6 F 75 N.S6.01
Aromatic ICL3 W 218 - S6 K 77 N.S6.03
Hydrophobic ICL3 W 218 - S6 K 77 N.S6.03
Van-der-waals ICL3 W 218 - S6 K 77 N.S6.03
Hydrophobic H8 H 284 8x47 s5s6 V 70 N.s5s6.07
Ionic TM5 K 209 5x71 s17s18 E 313 C.s17s18.39
Polar TM5 K 209 5x71 s17s18 E 313 C.s17s18.39
Hydrophobic TM6 H 225 6x31 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 H 225 6x31 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 228 6x34 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 A 228 6x34 s5s6 L 71 N.s5s6.08
Aromatic TM6 H 225 6x31 S6 F 75 N.S6.01
Hydrophobic TM6 H 225 6x31 S6 F 75 N.S6.01
Van-der-waals TM6 H 225 6x31 S6 F 75 N.S6.01
Hydrophobic TM6 L 231 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 L 231 6x37 s5s6 L 71 N.s5s6.08
Hydrophobic H8 P 285 8x48 s5s6 G 72 N.s5s6.09
Van-der-waals H8 P 285 8x48 s5s6 G 72 N.s5s6.09
Ionic ICL1 R 40 - s20c D 402 C.s20c.12
Polar ICL1 R 40 - s20c D 402 C.s20c.12
Hydrophobic ICL1 R 40 - s20c D 402 C.s20c.12
Van-der-waals ICL1 R 40 - s20c D 402 C.s20c.12
Polar TM6 Q 221 6x27 S6 D 78 N.S6.04
Van-der-waals TM6 Q 221 6x27 S6 D 78 N.S6.04
Aromatic TM5 H 206 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 206 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 206 5x68 s15s16 F 244 C.s15s16.03
Aromatic TM5 H 206 5x68 S6 F 75 N.S6.01
Hydrophobic TM5 H 206 5x68 S6 F 75 N.S6.01
Van-der-waals TM5 H 206 5x68 S6 F 75 N.S6.01
Ionic TM3 K 109 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 K 109 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 K 109 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 109 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic ICL2 R 123 34x55 s8s9 T 136 N.s8s9.07
Ionic H8 K 286 8x49 s20c E 405 C.s20c.15
Polar H8 K 286 8x49 s20c E 405 C.s20c.15
Van-der-waals H8 K 286 8x49 s20c E 405 C.s20c.15
Ionic TM3 K 109 3x53 s5s6 E 66 N.s5s6.03
Polar TM3 K 109 3x53 s5s6 E 66 N.s5s6.03
Van-der-waals TM3 K 109 3x53 s5s6 E 66 N.s5s6.03
Polar H8 H 284 8x47 s5s6 D 69 N.s5s6.06
Polar TM3 Y 106 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 Y 106 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 Y 106 3x50 s5s6 V 70 N.s5s6.07
Polar ICL2 N 112 34x44 s15s16 N 245 C.s15s16.04
Hydrophobic ICL2 N 112 34x44 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 N 112 34x44 s15s16 N 245 C.s15s16.04
Hydrophobic TM6 A 228 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 228 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 K 122 34x54 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 122 34x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 M 232 6x38 s5s6 L 71 N.s5s6.08
Ionic ICL2 K 122 34x54 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 Y 106 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 Y 106 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 110 3x54 s5s6 V 70 N.s5s6.07
Hydrophobic TM6 Q 221 6x27 S6 R 76 N.S6.02
Polar TM3 K 109 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM2 S 44 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 S 44 2x39 s5s6 V 70 N.s5s6.07
Polar ICL2 N 112 34x44 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 N 112 34x44 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 N 112 34x44 s15s16 F 244 C.s15s16.03
Polar ICL2 Q 114 34x46 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 Q 114 34x46 s15s16 T 246 C.s15s16.05
Van-der-waals TM3 I 110 3x54 s5s6 D 67 N.s5s6.04
Hydrophobic H8 P 285 8x48 s5s6 L 71 N.s5s6.08
Hydrophobic TM3 I 110 3x54 s5s6 L 73 N.s5s6.10
Polar TM5 N 213 5x75 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 N 213 5x75 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 N 213 5x75 s17s18 E 313 C.s17s18.39
Hydrophobic TM3 I 110 3x54 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 I 110 3x54 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 A 224 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 224 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 L 119 34x51 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 L 119 34x51 s8s9 T 136 N.s8s9.07