Beta-arrestin-2 - TAS2R4 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R4 81.3
Beta-arrestin-2 80.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
01
iPTM Score: 0.5
01
PAE mean: 17.7
031


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:
E03D04V07s5s6F01D04S6F03S04T05s15s16ArrestinK34x54K3x53Q6x27N34x44H6x31Y3x50W-H5x68GPCRInteractions:AromaticHydrophobicIonicPolarVan der waalsArrestin segments:s5s6S6s15s16GPCR segments:ICL2TM3ICL3TM5TM6

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

ACDEFGHIKLMNPQRSTVWY-_+van-der-waalshydrophobicionicaromaticpolar
null2x372x383x503x533x5434x4434x4634x545x655x685x715x725x756x276x306x316x346x376x388x48C.s17s18.39C.s15s16.05C.s15s16.04C.s15s16.03N.S6.06N.S6.05N.S6.04N.S6.03N.S6.02N.S6.01N.s5s6.10N.s5s6.09N.s5s6.08N.s5s6.07N.s5s6.04N.s5s6.03Res. Pos.TAS2R4 (AFM_TA2R4_HUMAN_ARRB2_HUMAN)- (AFM_TA2R4_HUMAN_ARRB2_HUMAN)---------------------SSYKINQKLHKMNQAHALMPSSNQKYKILHKMNQAHALMPWEFSTDVLLEKRDFGLF

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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