Beta-arrestin-1 - TAS2R5 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Beta

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R5 72.8
Beta-arrestin-1 79.6
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.6


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Q 120 34x55 s8s9 T 136 N.s8s9.07
Polar TM7 G 275 7x56 s5s6 G 72 N.s5s6.09
Hydrophobic TM7 G 275 7x56 s5s6 G 72 N.s5s6.09
Van-der-waals TM7 G 275 7x56 s5s6 G 72 N.s5s6.09
Polar ICL2 T 109 34x44 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 T 109 34x44 s15s16 F 244 C.s15s16.03
Van-der-waals ICL2 T 109 34x44 s15s16 F 244 C.s15s16.03
Hydrophobic ICL2 T 109 34x44 s15s16 N 245 C.s15s16.04
Van-der-waals ICL2 T 109 34x44 s15s16 N 245 C.s15s16.04
Hydrophobic TM5 L 195 5x65 S6 F 75 N.S6.01
Polar TM6 R 213 6x27 S5 F 61 N.S5.10
Van-der-waals TM6 R 213 6x27 S5 F 61 N.S5.10
Hydrophobic TM5 M 202 5x72 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 M 202 5x72 s15s16 F 244 C.s15s16.03
Hydrophobic TM7 G 275 7x56 s5s6 V 70 N.s5s6.07
Hydrophobic TM5 L 195 5x65 s5s6 L 73 N.s5s6.10
Aromatic TM6 R 213 6x27 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 R 213 6x27 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 R 213 6x27 s15s16 F 244 C.s15s16.03
Van-der-waals TM6 R 213 6x27 S5 Y 63 N.S5.12
Hydrophobic H8 I 276 8x47 s5s6 V 70 N.s5s6.07
Van-der-waals H8 I 276 8x47 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 Y 103 3x50 s5s6 L 71 N.s5s6.08
Van-der-waals TM3 Y 103 3x50 s5s6 L 71 N.s5s6.08
Hydrophobic TM6 R 213 6x27 S6 K 77 N.S6.03
Van-der-waals TM6 R 213 6x27 S6 K 77 N.S6.03
Hydrophobic TM5 M 202 5x72 S6 K 77 N.S6.03
Polar TM3 Y 103 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 Y 103 3x50 s5s6 V 70 N.s5s6.07
Van-der-waals TM3 Y 103 3x50 s5s6 V 70 N.s5s6.07
Hydrophobic TM3 F 102 3x49 s5s6 D 67 N.s5s6.04
Hydrophobic TM6 A 216 6x30 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 216 6x30 s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 T 109 34x44 s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 T 109 34x44 s5s6 R 65 N.s5s6.02
Hydrophobic TM5 M 202 5x72 s15s16 L 243 C.s15s16.02
Polar ICL2 D 111 34x46 s15s16 T 246 C.s15s16.05
Van-der-waals ICL2 D 111 34x46 s15s16 T 246 C.s15s16.05
Ionic H8 R 278 8x49 s20c E 405 C.s20c.15
Polar H8 R 278 8x49 s20c E 405 C.s20c.15
Hydrophobic H8 R 278 8x49 s20c E 405 C.s20c.15
Van-der-waals H8 R 278 8x49 s20c E 405 C.s20c.15
Hydrophobic H8 I 276 8x47 s5s6 D 69 N.s5s6.06
Van-der-waals H8 I 276 8x47 s5s6 D 69 N.s5s6.06
Polar TM5 H 205 5x75 s17s18 N 311 C.s17s18.37
Hydrophobic TM3 I 107 3x54 s5s6 L 68 N.s5s6.05
Van-der-waals TM3 I 107 3x54 s5s6 L 68 N.s5s6.05
Polar TM3 I 107 3x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 107 3x54 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 I 107 3x54 s5s6 R 65 N.s5s6.02
Hydrophobic TM3 I 107 3x54 s5s6 L 71 N.s5s6.08
Polar TM6 R 213 6x27 S6 F 75 N.S6.01
Hydrophobic TM6 R 213 6x27 S6 F 75 N.S6.01
Van-der-waals TM6 R 213 6x27 S6 F 75 N.S6.01
Polar TM3 K 106 3x53 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 K 106 3x53 s5s6 R 65 N.s5s6.02
Hydrophobic TM6 S 223 6x37 s5s6 L 71 N.s5s6.08
Van-der-waals TM6 S 223 6x37 s5s6 L 71 N.s5s6.08
Ionic TM3 K 106 3x53 s5s6 D 67 N.s5s6.04
Polar TM3 K 106 3x53 s5s6 D 67 N.s5s6.04
Hydrophobic TM3 K 106 3x53 s5s6 D 67 N.s5s6.04
Van-der-waals TM3 K 106 3x53 s5s6 D 67 N.s5s6.04
Polar TM6 R 213 6x27 S6 R 76 N.S6.02
Hydrophobic TM6 R 213 6x27 S6 R 76 N.S6.02
Van-der-waals TM6 R 213 6x27 S6 R 76 N.S6.02
Aromatic TM5 H 198 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM5 H 198 5x68 s15s16 F 244 C.s15s16.03
Van-der-waals TM5 H 198 5x68 s15s16 F 244 C.s15s16.03
Hydrophobic TM6 H 217 6x31 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 H 217 6x31 s5s6 L 73 N.s5s6.10
Polar TM2 Y 44 2x39 s5s6 V 70 N.s5s6.07
Hydrophobic TM2 Y 44 2x39 s5s6 V 70 N.s5s6.07
Van-der-waals TM2 Y 44 2x39 s5s6 V 70 N.s5s6.07
Ionic TM5 H 205 5x75 s17s18 E 313 C.s17s18.39
Polar TM5 H 205 5x75 s17s18 E 313 C.s17s18.39
Hydrophobic TM5 H 205 5x75 s17s18 E 313 C.s17s18.39
Van-der-waals TM5 H 205 5x75 s17s18 E 313 C.s17s18.39
Aromatic TM6 H 217 6x31 S6 F 75 N.S6.01
Hydrophobic TM6 H 217 6x31 S6 F 75 N.S6.01
Van-der-waals TM6 H 217 6x31 S6 F 75 N.S6.01
Polar H8 P 277 8x48 s5s6 D 69 N.s5s6.06
Hydrophobic H8 P 277 8x48 s5s6 D 69 N.s5s6.06
Van-der-waals H8 P 277 8x48 s5s6 D 69 N.s5s6.06
Polar H8 Q 281 8x52 s20c E 407 C.s20c.17
Van-der-waals H8 Q 281 8x52 s20c E 407 C.s20c.17
Hydrophobic TM6 A 220 6x34 s5s6 L 73 N.s5s6.10
Van-der-waals TM6 A 220 6x34 s5s6 L 73 N.s5s6.10
Hydrophobic TM6 A 220 6x34 s5s6 L 71 N.s5s6.08
Hydrophobic TM7 G 275 7x56 s5s6 L 71 N.s5s6.08
Van-der-waals TM7 G 275 7x56 s5s6 L 71 N.s5s6.08
Polar TM3 K 106 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic TM3 K 106 3x53 s8s9 K 138 N.s8s9.09
Van-der-waals TM3 K 106 3x53 s8s9 K 138 N.s8s9.09
Hydrophobic H8 P 277 8x48 s5s6 G 72 N.s5s6.09
Ionic ICL3 R 209 - s9s10 E 155 N.s9s10.07
Polar ICL3 R 209 - s9s10 E 155 N.s9s10.07
Hydrophobic ICL3 R 209 - s9s10 E 155 N.s9s10.07
Van-der-waals ICL3 R 209 - s9s10 E 155 N.s9s10.07
Ionic H8 R 278 8x49 s5s6 D 69 N.s5s6.06
Polar H8 R 278 8x49 s5s6 D 69 N.s5s6.06
Van-der-waals H8 R 278 8x49 s5s6 D 69 N.s5s6.06
Polar ICL2 K 119 34x54 s8s9 T 136 N.s8s9.07
Hydrophobic ICL2 K 119 34x54 s8s9 T 136 N.s8s9.07
Van-der-waals ICL2 K 119 34x54 s8s9 T 136 N.s8s9.07