S-arrestin - TAS2R5 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

ARRESTIN FAMILY

Visual

DATE

2025-02-19

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R5 73.6
S-arrestin 79.9
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.0


GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic TM3 Y 103 3x50 s5s6 V 78 N.s5s6.07
Van-der-waals TM3 Y 103 3x50 s5s6 V 78 N.s5s6.07
Ionic TM1 K 38 1x64 s20c E 395 C.s20c.14
Polar TM1 K 38 1x64 s20c E 395 C.s20c.14
Van-der-waals TM1 K 38 1x64 s20c E 395 C.s20c.14
Hydrophobic TM3 I 107 3x54 S6 F 83 N.S6.01
Van-der-waals TM3 I 107 3x54 S6 F 83 N.S6.01
Hydrophobic TM6 S 223 6x37 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 S 223 6x37 s5s6 I 79 N.s5s6.08
Aromatic TM5 H 198 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM5 H 198 5x68 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 H 198 5x68 s15s16 Y 254 C.s15s16.03
Hydrophobic TM6 H 217 6x31 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 H 217 6x31 s5s6 L 81 N.s5s6.10
Hydrophobic TM6 A 216 6x30 s5s6 L 81 N.s5s6.10
Hydrophobic ICL2 T 109 34x44 S5 Y 71 N.S5.12
Van-der-waals ICL2 T 109 34x44 S5 Y 71 N.S5.12
Hydrophobic TM5 L 195 5x65 S6 F 83 N.S6.01
Hydrophobic ICL3 R 209 - s9s10 A 163 N.s9s10.05
Van-der-waals ICL3 R 209 - s9s10 A 163 N.s9s10.05
Polar TM7 G 275 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic TM7 G 275 7x56 s5s6 I 79 N.s5s6.08
Van-der-waals TM7 G 275 7x56 s5s6 I 79 N.s5s6.08
Hydrophobic ICL2 D 111 34x46 s15s16 S 255 C.s15s16.04
Van-der-waals ICL2 D 111 34x46 s15s16 S 255 C.s15s16.04
Ionic TM1 E 34 1x60 s20c R 398 C.s20c.17
Polar TM1 E 34 1x60 s20c R 398 C.s20c.17
Hydrophobic H8 P 277 8x48 s5s6 G 80 N.s5s6.09
Polar TM6 R 213 6x27 S6 R 84 N.S6.02
Hydrophobic TM6 R 213 6x27 S6 R 84 N.S6.02
Van-der-waals TM6 R 213 6x27 S6 R 84 N.S6.02
Polar TM6 R 213 6x27 S6 R 85 N.S6.03
Hydrophobic TM6 R 213 6x27 S6 R 85 N.S6.03
Van-der-waals TM6 R 213 6x27 S6 R 85 N.S6.03
Hydrophobic TM5 M 202 5x72 S6 R 85 N.S6.03
Van-der-waals TM5 M 202 5x72 S6 R 85 N.S6.03
Hydrophobic TM3 K 106 3x53 s5s6 I 76 N.s5s6.05
Hydrophobic TM6 A 220 6x34 s5s6 I 79 N.s5s6.08
Polar ICL2 T 109 34x44 s15s16 Y 254 C.s15s16.03
Hydrophobic ICL2 T 109 34x44 s15s16 Y 254 C.s15s16.03
Van-der-waals ICL2 T 109 34x44 s15s16 Y 254 C.s15s16.03
Hydrophobic TM1 K 38 1x64 s20c R 398 C.s20c.17
Van-der-waals TM1 K 38 1x64 s20c R 398 C.s20c.17
Polar TM7 G 275 7x56 s5s6 G 80 N.s5s6.09
Hydrophobic TM7 G 275 7x56 s5s6 G 80 N.s5s6.09
Van-der-waals TM7 G 275 7x56 s5s6 G 80 N.s5s6.09
Ionic TM6 R 213 6x27 s9s10 E 165 N.s9s10.07
Hydrophobic TM5 M 202 5x72 s15s16 Y 254 C.s15s16.03
Van-der-waals TM5 M 202 5x72 s15s16 Y 254 C.s15s16.03
Hydrophobic TM2 Y 44 2x39 s5s6 V 78 N.s5s6.07
Ionic TM5 H 205 5x75 s17s18 D 321 C.s17s18.37
Polar TM5 H 205 5x75 s17s18 D 321 C.s17s18.37
Hydrophobic TM5 H 205 5x75 s17s18 D 321 C.s17s18.37
Van-der-waals TM5 H 205 5x75 s17s18 D 321 C.s17s18.37
Polar TM5 H 205 5x75 S6 R 85 N.S6.03
Hydrophobic TM5 H 205 5x75 S6 R 85 N.S6.03
Van-der-waals TM5 H 205 5x75 S6 R 85 N.S6.03
Ionic TM1 K 38 1x64 s5s6 D 75 N.s5s6.04
Polar TM1 K 38 1x64 s5s6 D 75 N.s5s6.04
Van-der-waals TM1 K 38 1x64 s5s6 D 75 N.s5s6.04
Polar TM5 H 205 5x75 s17s18 T 323 C.s17s18.39
Hydrophobic TM5 H 205 5x75 s17s18 T 323 C.s17s18.39
Van-der-waals TM5 H 205 5x75 s17s18 T 323 C.s17s18.39
Hydrophobic TM5 M 202 5x72 s15s16 L 253 C.s15s16.02
Van-der-waals TM5 M 202 5x72 s15s16 L 253 C.s15s16.02
Hydrophobic TM3 I 107 3x54 s5s6 I 79 N.s5s6.08
Van-der-waals TM6 R 213 6x27 s5s6 T 82 N.s5s6.11
Hydrophobic TM3 I 107 3x54 s5s6 L 81 N.s5s6.10
Van-der-waals TM3 I 107 3x54 s5s6 L 81 N.s5s6.10
Hydrophobic H8 R 278 8x49 s20c R 398 C.s20c.17
Van-der-waals H8 R 278 8x49 s20c R 398 C.s20c.17
Hydrophobic ICL2 T 109 34x44 s15s16 S 255 C.s15s16.04
Aromatic TM6 H 217 6x31 S6 F 83 N.S6.01
Hydrophobic TM6 H 217 6x31 S6 F 83 N.S6.01
Van-der-waals TM6 H 217 6x31 S6 F 83 N.S6.01
Hydrophobic H8 P 277 8x48 s5s6 D 77 N.s5s6.06
Van-der-waals H8 P 277 8x48 s5s6 D 77 N.s5s6.06
Ionic H8 R 278 8x49 s5s6 D 75 N.s5s6.04
Polar H8 R 278 8x49 s5s6 D 75 N.s5s6.04
Van-der-waals H8 R 278 8x49 s5s6 D 75 N.s5s6.04
Polar TM6 D 211 6x25 S6 D 86 N.S6.04
Hydrophobic TM6 D 211 6x25 S6 D 86 N.S6.04
Van-der-waals TM6 D 211 6x25 S6 D 86 N.S6.04
Hydrophobic TM3 Y 103 3x50 s5s6 I 79 N.s5s6.08
Van-der-waals TM3 Y 103 3x50 s5s6 I 79 N.s5s6.08
Ionic TM1 R 33 1x59 s20c E 405 C.s20c.24
Polar TM1 R 33 1x59 s20c E 405 C.s20c.24
Hydrophobic TM5 L 195 5x65 s5s6 L 81 N.s5s6.10
Polar TM3 K 106 3x53 s5s6 Q 73 N.s5s6.02
Hydrophobic TM3 K 106 3x53 s5s6 Q 73 N.s5s6.02
Van-der-waals TM3 K 106 3x53 s5s6 Q 73 N.s5s6.02
Ionic TM6 R 213 6x27 S6 D 86 N.S6.04
Polar TM6 R 213 6x27 S6 D 86 N.S6.04
Hydrophobic TM6 R 213 6x27 S6 D 86 N.S6.04
Van-der-waals TM6 R 213 6x27 S6 D 86 N.S6.04
Ionic TM6 K 215 6x29 s9s10 E 164 N.s9s10.06
Hydrophobic TM6 A 220 6x34 s5s6 L 81 N.s5s6.10
Van-der-waals TM6 A 220 6x34 s5s6 L 81 N.s5s6.10
Ionic H8 R 278 8x49 s5s6 D 77 N.s5s6.06
Polar H8 R 278 8x49 s5s6 D 77 N.s5s6.06
Polar ICL2 D 111 34x46 s15s16 S 256 C.s15s16.05
Hydrophobic ICL2 D 111 34x46 s15s16 S 256 C.s15s16.05
Van-der-waals ICL2 D 111 34x46 s15s16 S 256 C.s15s16.05