G14 - TAS2R5 complex model

GPCR CLASS (FAMILY)

T2 (Taste 2)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

Chain pLDDT score avg
TAS2R5 74.6
subunit alpha-14 86.7
Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

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Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 Y 103 3x50 G.H5 L 354 G.H5.25
Polar TM3 Y 103 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 Y 103 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 Y 103 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM5 M 202 5x72 G.H5 A 338 G.H5.09
Van-der-waals TM5 M 202 5x72 G.H5 A 338 G.H5.09
Ionic TM6 H 217 6x31 G.H5 D 342 G.H5.13
Polar TM6 H 217 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM6 H 217 6x31 G.H5 D 342 G.H5.13
Van-der-waals TM6 H 217 6x31 G.H5 D 342 G.H5.13
Hydrophobic TM6 T 219 6x33 G.H5 V 355 G.H5.26
Hydrophobic TM3 I 107 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 I 107 3x54 G.H5 L 345 G.H5.16
Hydrophobic TM7 G 275 7x56 G.H5 N 353 G.H5.24
Van-der-waals TM7 G 275 7x56 G.H5 N 353 G.H5.24
Hydrophobic TM3 I 107 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM6 V 212 6x26 G.h4s6 E 317 G.h4s6.12
Hydrophobic ICL2 L 116 34x51 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 L 116 34x51 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM6 H 217 6x31 G.H5 L 349 G.H5.20
Hydrophobic TM7 G 275 7x56 G.H5 V 355 G.H5.26
Hydrophobic TM6 H 217 6x31 G.H5 L 345 G.H5.16
Van-der-waals TM6 H 217 6x31 G.H5 L 345 G.H5.16
Hydrophobic TM6 A 216 6x30 G.H5 V 355 G.H5.26
Van-der-waals TM6 A 216 6x30 G.H5 V 355 G.H5.26
Hydrophobic TM5 M 202 5x72 G.H5 D 342 G.H5.13
Van-der-waals TM5 M 202 5x72 G.H5 D 342 G.H5.13
Ionic TM5 H 198 5x68 G.H5 D 342 G.H5.13
Polar TM5 H 198 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM5 H 198 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 H 198 5x68 G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 209 - G.h4s6 V 319 G.h4s6.20
Ionic ICL3 R 209 - G.H5 D 342 G.H5.13
Polar ICL3 R 209 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 209 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 209 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 T 109 34x44 G.H5 K 341 G.H5.12
Hydrophobic ICL2 D 111 34x46 G.s2s3 E 193 G.s2s3.01
Van-der-waals ICL2 D 111 34x46 G.s2s3 E 193 G.s2s3.01
Hydrophobic TM3 I 107 3x54 G.H5 N 348 G.H5.19
Hydrophobic TM5 H 205 5x75 G.H5 F 335 G.H5.06
Hydrophobic H8 I 276 8x47 G.H5 N 353 G.H5.24
Van-der-waals H8 I 276 8x47 G.H5 N 353 G.H5.24
Polar ICL2 Q 120 34x55 G.HN D 31 G.HN.53
Polar TM2 Y 44 2x39 G.H5 N 353 G.H5.24
Van-der-waals TM2 Y 44 2x39 G.H5 N 353 G.H5.24
Polar ICL3 R 209 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 R 209 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 209 - G.S6 Y 321 G.S6.02
Polar TM6 S 223 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 220 6x34 G.H5 L 349 G.H5.20
Van-der-waals TM6 A 220 6x34 G.H5 L 349 G.H5.20
Polar TM6 R 213 6x27 G.h4s6 V 319 G.h4s6.20
Hydrophobic TM6 R 213 6x27 G.h4s6 V 319 G.h4s6.20
Van-der-waals TM6 R 213 6x27 G.h4s6 V 319 G.h4s6.20
Polar TM3 K 106 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 K 106 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 K 106 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 M 202 5x72 G.S6 Y 321 G.S6.02
Van-der-waals TM5 M 202 5x72 G.S6 Y 321 G.S6.02
Polar TM6 H 217 6x31 G.H5 Q 346 G.H5.17
Hydrophobic TM6 H 217 6x31 G.H5 Q 346 G.H5.17
Van-der-waals TM6 H 217 6x31 G.H5 Q 346 G.H5.17
Aromatic TM3 F 102 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM3 F 102 3x49 G.H5 F 352 G.H5.23
Van-der-waals TM3 F 102 3x49 G.H5 F 352 G.H5.23
Hydrophobic TM5 H 198 5x68 G.H5 L 345 G.H5.16
Van-der-waals TM5 H 198 5x68 G.H5 L 345 G.H5.16
Polar TM6 R 213 6x27 G.S6 Y 321 G.S6.02
Hydrophobic TM6 R 213 6x27 G.S6 Y 321 G.S6.02
Van-der-waals TM6 R 213 6x27 G.S6 Y 321 G.S6.02
Polar TM6 A 220 6x34 G.H5 L 354 G.H5.25
Hydrophobic TM6 A 220 6x34 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 220 6x34 G.H5 L 354 G.H5.25
Ionic ICL2 D 111 34x46 G.H5 K 341 G.H5.12
Polar ICL2 D 111 34x46 G.H5 K 341 G.H5.12
Hydrophobic ICL2 D 111 34x46 G.H5 K 341 G.H5.12
Van-der-waals ICL2 D 111 34x46 G.H5 K 341 G.H5.12
Hydrophobic TM6 A 216 6x30 G.H5 Q 346 G.H5.17
Van-der-waals TM6 A 216 6x30 G.H5 Q 346 G.H5.17
Hydrophobic TM6 L 224 6x38 G.H5 L 354 G.H5.25
Ionic TM6 R 213 6x27 G.H5 D 342 G.H5.13
Polar TM6 R 213 6x27 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 213 6x27 G.H5 D 342 G.H5.13
Hydrophobic TM3 I 107 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 I 107 3x54 G.H5 L 354 G.H5.25
Polar TM6 R 213 6x27 G.H5 Q 346 G.H5.17
Hydrophobic TM6 R 213 6x27 G.H5 Q 346 G.H5.17
Van-der-waals TM6 R 213 6x27 G.H5 Q 346 G.H5.17
Hydrophobic TM5 L 195 5x65 G.H5 L 345 G.H5.16
Hydrophobic TM3 K 106 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 K 106 3x53 G.H5 F 352 G.H5.23
Polar ICL3 A 207 - G.S6 S 322 G.S6.03
Hydrophobic TM6 A 220 6x34 G.H5 V 355 G.H5.26
Polar TM2 Y 44 2x39 G.H5 F 352 G.H5.23
Aromatic TM2 Y 44 2x39 G.H5 F 352 G.H5.23
Hydrophobic TM2 Y 44 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 Y 44 2x39 G.H5 F 352 G.H5.23
Hydrophobic TM3 I 107 3x54 G.H5 F 352 G.H5.23